EP899 Diagnostic value of postoperative platelet-to-white blood cell ratio (PC/WCC) after splenectomy in advanced ovarian cancer patients

Lathouras, Kostas; Panagakis, Georgios; Bowden, Sarah; Saliaris, Konstantinos; Saso, Srdjan; Haidopoulos, Dimitrios; Fotopoulou, C

doi:10.1136/ijgc-2019-esgo.946

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“…An elevated WBC count is often considered an indicator of infection, while leukocytosis is also a physiologic process that occurs after splenectomy. Several studies have reported that postoperative WBC counts should be adjusted to evaluate the presence of infections among patients undergoing splenectomy [20,21]. Maatman et al [22] who retrospectively reviewed 158 patients undergoing DPS reported that POD3 WBC counts above 16×10 9 /L or an increase in WBC counts greater than 9×10 9 /L from preoperative baseline was associated with major morbidity.…”

Section: Discussionmentioning

confidence: 99%

Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study

Cui

Liu

Zheng

et al. 2020

Preprint

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Background: The clinical outcomes of distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) patients have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood. Methods: Information from patients undergoing distal pancreatectomy (DP) between January 2014 and June 2019 at a single institution was reviewed. A linear mixed-effect model was used to compare dynamic hematological changes between different groups. Results: In total, 302 patients who underwent DP were enrolled. In the long term, most postoperative hematological parameters remained significantly higher than preoperative levels in the DPS group, while postoperative lymphocyte, monocyte, basophil, and platelet levels returned to preoperative levels in the SPDP group. All postoperative hematological parameters except for red blood cell count and serum hemoglobulin level were significantly higher in the DPS group than in the SPDP group. There were no significant differences in hematological changes between the splenic vessel preservation (SVP) and Warshaw technique (WT) groups. Conclusions: Postoperative hematological changes were significantly different between the DPS and SPDP groups. Compared to DPS, SPDP reduced abnormal hematological changes caused by splenectomy. SVP and WT were comparable in terms of postoperative hematological changes.

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Section: Discussionmentioning

confidence: 99%