EPA, an omega‐3 fatty acid, induces apoptosis in human pancreatic cancer cells: Role of ROS accumulation, caspase‐8 activation, and autophagy induction

Fukui, Masayuki; Kang, Ki Sung; Okada, Kazushi; Zhu, Bao Ting

doi:10.1002/jcb.24354

Cited by 114 publications

(93 citation statements)

References 54 publications

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“…Previously, several reports have suggested a change in autophagy in cancer cell lines that are sensitive and display cytotoxic and/or cytostatic responses to physiological doses of PUFAs. [48][49][50][51][52][53] We explore whether increased autophagy is a part of the cellular response to PUFAs also in spontaneously arising ARPE-19 cells. If so, we hypothesize a correlation between the disease preventive effects of n-3 PUFAs and stimulation of autophagy in retinal pigment epithelial cells where the initial phases of AMD occurs.…”

Section: Introductionmentioning

confidence: 99%

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

et al. 2015

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Section: Introductionmentioning

confidence: 99%

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

et al. 2015

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“…In addition, EPA and DHA reduce the expression of Bcl2 and procaspase-8, and activation of EGFR in human breast cancer cell lines [19]. EPA and DHA induce ROS accumulation in breast and pancreatic cancer cell lines and trigger caspase-8-dependent apoptosis in vitro and in vivo [20,21]. DHA and EPA elevated the expression of the PTEN gene and its protein, peroxisome proliferator-activated receptor gamma (PPARγ), in breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Omega Fatty Acids on Bcl-2 Gene Expression and Protein Production in Cancerous Gastric Tissue

Ghanbarzadeh

Mohaddes

2017

mcij

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Introduction: Gastric cancer is the fourth common cancer and the second leading cause of death from cancer worldwide. Omega fatty acids are a group of non-saturated fatty acids of long chains derive from linolenic, linoleic and oleic fatty acids. The current study aimed at examining the possible effects of oral administration of omega-3, -6 and -9 fatty acids on gastric cancer cell apoptosis in patients with gastric adenocarcinoma via the evaluation of BCL2 gene and protein expression. Methods: In the present case-control study, a total of 34 patients with gastric cancer referring to the Endoscopy Clinic at Tabriz University of Medical Sciences were selected and divided into 2 groups (n = 17). In group 1, patients were treated by platinum drugs without any supplementation and in group 2, patients were treated by platinum drugs supplemented with omega-3, -6 and -9 fatty acids over 3 courses, which each lasted 3 weeks. After stomach biopsy, RNA extraction, cDNA synthesis and real-time polymerase chain reaction (RT-PCR) were performed. Results:The results showed that Bcl-2 gene and BCL2 protein expression in patients who received omega-3, -6 and -9 fatty acids with chemotherapy was lower than those of the ones who not received omega fatty acids. Also, there was a significant decrease in Bcl-2 gene expression (P < 0.05). Conclusions:The oral administration of omega-3, -6 and -9 fatty acids with the chemotherapeutic drug cis-platinum in patients with gastric adenocarcinoma could decrease Bcl-2 gene expression and BCL2 protein production in the cancerous gastric tissue.

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“…EPA has been considered to inhibit the growth and development of colon, breast and liver cancer and leukemia in vivo and in vitro [18]. Furthermore, many studies have demonstrated that EPA could induce apoptosis in cancer cells and have suggested mechanisms for this biological function [19][20][21].…”

Section: Cardioprotective Effectmentioning

confidence: 99%

Researches on the Pharmacological Effects of Eicosapentaenoic Acid

Pang¹,

Zhang²,

Tian³

et al. 2015

Journal of Pharmaceutics and Drug Development

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Fish oils are the most common source of omega-3 polyunsaturated fatty acids (n-3 PUFAs), mainly eicosapentaenoic acid (EPA). It has been pointed out protective effects and beneficial effects of EPA on body weight reduction, heart health, blood lipid profile, cardiovascular diseases and other diseases. Based on its biological activities, EPA may be developed to a complementary and alternative medicine through further research. In this paper, the pharmacological effects of EPA were summarized by reviewing the recent related literatures.Abstract ISSN: 2348-9782 In the late 1970s, Dyerberg et al. [1] highlighted the cardio protective effect of dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) for the first time. As the decades passed, n-3 PUFAs have been developed as dietary supplements, and it is now widely accepted that n-3PUFAs are incorporated as structural components into cell membrane phospholipids in the blood and tissues, and they mediate an array of biological effects [2,3]. Keywords: Eicosapentaenoic acid; Pharmacological effects; Research progressEicosapentaenoic acid (EPA) is typical omega-3 polyunsaturated fatty acids found in fish and fish oils, and it is derived from another n-3 PUFA, α-linolenic acid (α-LNA) ( Figure 1) [4][5][6]. Many reports have shown that EPA has protective roles against many diseases. This paper reviewed the main pharmacological effects of EPA, which provided reference to further study and develop EPA. The pharmacological effects of EPA Obesity is considered as an important public health disease, along with at least three of the following: abdominal obesity, hypertension, hyperglycemia, reduced plasma high-density lipoprotein (HDL), cholesterol and elevated plasma triglyceride (TG). Given the side effects and limitations of pharmacologic therapies, it is greatly needed to develop nutritional interventions which may not only prevent or treat obesity but also inhibit its associated diseases. Some studies reported that n-3 PUFAs had positive effects on body weight reduction [7,8]. Furthermore, the effect of EPA supplementation on overweight has been scarcely investigated and its therapeutic effects have been confirmed.In a review of randomized controlled trials, Monique J LeMieux et al. [9] investigated the possible mechanisms to explain the antilipogenic effect of EPA. The results showed that supplementation with EPA in the high fat diet could prevent diet-induced obesity and insulin resistance. Both glucose homeostasis and metabolic profile were ameliorated by reducing adipose tissue inflammation, and this was done possibly through the reduction of lipid accumulation, prostaglandin (PG) synthesis and adipocyte size ( Figure 2). A clinical trial showed that the supplementation with EPA combination with α-lipoic acid at lower doses (300mg/day) could promote fat mass reduction and weight loss in healthy overweight women following an energy-restricted balanced diet [10]. Anti-lipogenic effectAlthough increasing evidence have showed that consumption of EPA could decrease ris...

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EPA, an omega‐3 fatty acid, induces apoptosis in human pancreatic cancer cells: Role of ROS accumulation, caspase‐8 activation, and autophagy induction

Cited by 114 publications

References 54 publications

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

The Effect of Omega Fatty Acids on Bcl-2 Gene Expression and Protein Production in Cancerous Gastric Tissue

Researches on the Pharmacological Effects of Eicosapentaenoic Acid

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