Epedimic and endemic HLA-B and DR associations in mucocutaneous lymph node syndrome

Krensky, Alan M.; Grady, Stafford; Shanley, Karen; Berenberg, William; Yunis, Edmond J.

doi:10.1016/0198-8859(83)90063-0

Cited by 31 publications

(24 citation statements)

References 10 publications

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“…One of the reasons that KD has been regarded as infectiontriggered disorder is past epidemic in Japan and in the United States. HLA-B44 was predominant in the epidemic KD cases in Boston (11). This finding was supported by the report by Kaslow et al (15) in which HLA-A2, B44 and Cw5 antigen combination was associated with KD patients involved in an outbreak in Maryland.…”

Section: Hlasupporting

confidence: 80%

“…Matsuda et al (8) and Kato et al (9) reported that Japanese specific variant of HLA-Bw22 (now called as Bw54) was predominant in Japanese KD patients. In the studies of white (10,11) and Jewish population (12), association between HLA-Bw51 and KD was found. However, neither trend of association was replicated in the Southern Chinese population (13) and in the Korean population (14).…”

Section: Hlamentioning

confidence: 99%

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Molecular Genetics of Kawasaki Disease

Onouchi

2009

Pediatr Res

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Kawasaki disease (KD) is a leading cause of acquired cardiac disease of children in the developed countries. The pathogen that triggers this perplexing disease is still unknown after 40 y from the first description. Epidemiologic findings have made us believe that there are considerable genetic components in the etiology and some candidate genetic variations, which confer susceptibility to KD or risk for coronary artery lesions have been identified. However, most of them remain to be definitively confirmed by replication studies with large cohorts. In this article, I review the candidate gene association studies to date. I also introduce our recent findings in genome-wide approach, which revealed the importance of Ca 2ϩ / nuclear factor of activated T-cells pathway in the pathogenesis of KD.

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Section: Hlasupporting

confidence: 80%

Section: Hlamentioning

confidence: 99%

Molecular Genetics of Kawasaki Disease

Onouchi

2009

Pediatr Res

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“…The association between HLA and development of KD remains controversial (Barron et al 1992;Fildes et al 1992;Kaslow et al 1985;Krensky et al 1981Krensky et al , 1983Matsuda et al 1977). No evidence of linkage was observed in the 6p21 region in the present study, which might indicate that HLA does not play a major role in terms of KD susceptibility.…”

Section: Discussioncontrasting

confidence: 46%

A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12

Onouchi

Tamari²,

Takahashi³

et al. 2006

J Hum Genet

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Kawasaki disease (KD) is an acute systemic vasculitis syndrome that primarily affects infants and young children. The cause of KD is largely unknown, but its higher incidence in the Asian population and increased risk in patients' families suggests the existence of underlying genetic factors. To determine the loci of a susceptibility gene for KD, a genomewide linkage analysis with affected sib pairs was performed on 78 family samples collected from all over Japan. Multipoint linkage analysis using MAP-MAKER/SIBS 2.0 identified evidence of linkage on 12q24 [maximum lod score (MLS) = 2.69]. Possible linkage (MLS > 1.0) was also found on 4q35, 5q34, 6q27, 7p15, 8q24, 18q23, 19q13, Xp22, and Xq27. This is the first large-scale study of the genetic susceptibility to KD, and our results, combined with the accumulated knowledge of the human genome, could greatly promote research on identification of the molecular pathogenesis of KD.

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“…The high incidence of KD in Japan and among Americans of Japanese descent suggests that these groups may be genetically predisposed to this disease (2,6). Linkage of different genetic markers (class I and class II MHC antigens, Ig allotypes) with KD has been sought, but only weak associations have been found (7)(8)(9)(10)(11)(12)(13).…”

mentioning

confidence: 99%