Ependymoma

Teo, Charles; Nakaji, Peter; Symons, Patricia; Tobias, Vivienne; Cohn, Richard J.; Smee, Robert

doi:10.1007/s00381-003-0753-x

Cited by 53 publications

(24 citation statements)

References 99 publications

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“…Intracranial tumors are predominant in pediatric patients (90%), whereas most adults show spinal manifestation (60%; refs. 3,4). Spinal tumor localization is usually associated with a favorable prognosis after gross total resection and does not need to be treated with adjuvant therapy (5,6).…”

mentioning

confidence: 99%

Identification of Gains on 1q and Epidermal Growth Factor Receptor Overexpression as Independent Prognostic Markers in Intracranial Ependymoma

Meyer

Korshunov

Benner

et al. 2006

Clinical Cancer Research

210

191

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Purpose: Pathogenesis of ependymomas is still poorly understood and molecular markers for risk-adapted patient stratification are not available. Our aim was to screen for novel genomic imbalances and prognostic markers in ependymal tumors. Experimental Design: We analyzed 68 sporadic tumors by matrix-based comparative genomic hybridization using DNA microarrays containing >6,400 genomic DNA fragments. Novel recurrent genomic gains were validated by fluorescence in situ hybridization using a tissue microarray consisting of 170 intracranial ependymomas. Candidate genes were also tested for mRNA expression by quantitative real-time PCR, and protein expression was determined by immunohistochemistry on the tissue microarray. Results: Chromosomal gain of 1q correlated with pediatric patients (P = 0.004), intracranial ependymomas (P = 0.05), and tumors of grade III (P = 0.002). Gain of1q21.1-32.1was associated with tumor recurrence in intracranial ependymomas (P < 0.001). Furthermore, gain of 1q25 as determined by fluorescence in situ hybridization represented an independent prognostic marker for either recurrence-free survival (P < 0.001) or overall survival (P = 0.003). Recurrent gains at 5p15.33 covering hTERT were validated by immunohistochemistry, and elevated protein levels correlated with adverse prognosis (P = 0.01). In addition to frequent gains and high-level amplification of epidermal growth factor receptor (EGFR) at 7p11.2, immunohistochemistry revealed protein overexpression to be correlated with poor prognosis (P = 0.002). EGFR protein status subdivides intracranial grade II ependymomas into two different risk groups (P = 0.03) as shown by multivariate analysis. Conclusions: Thus, the states of 1q25 and EGFR represent independent prognostic markers for intracranial ependymomas to identify patient subgroups with different risk profiles in further clinical investigations. Moreover, EGFR might serve as therapeutic target for more specific chemotherapy applications.

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mentioning

confidence: 99%

Identification of Gains on 1q and Epidermal Growth Factor Receptor Overexpression as Independent Prognostic Markers in Intracranial Ependymoma

Meyer

Korshunov

Benner

et al. 2006

Clinical Cancer Research

210

191

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“…The LOH studies have identified LOH of 22q as the most frequent change in approximately 30% of ependymomas, 267 contributed partially by the loss or structural abnor- 267 A SKY analysis has been performed in one case of ependymoma reported by our group, 257 and showed no additional structural aberrations from the original Gbanded karyotype (http://www.ncbi.nlm.nih.gov/sky/) (Fig. 2).…”

Section: Neurosurg Focus / Volume 19 / November 2005mentioning

confidence: 95%

“…Ependymomas are well-delineated, moderately cellular gliomas and are the third most common brain tumors in children. 267 The WHO classification differentiates four major types: ependymoma (WHO Grade II), anaplastic ependymoma (Grade III), myxopapillary ependymoma (Grade I), and subependymoma (Grade I) as well as the ependymal variants (cellular, papillary, epithelial, clear cell, and mixed). Whereas ependymomas occur in both children and adults, subependymomas and myxopapillary ependymomas are more common in adults.…”

Section: Neurosurg Focus / Volume 19 / November 2005mentioning

confidence: 99%

“…Whereas ependymomas occur in both children and adults, subependymomas and myxopapillary ependymomas are more common in adults. 267 The CGAP website identifies 106 ependymoma karyotypes 1,22,50,62,64,83,92,117,161,175,207,209,225,227,257,270,278,281,293,294 (also reviewed by Mazewski,et al 161 ). The karyotypes described are predominantly normal, and when abnormal are near-diploid, and are characterized by gains and losses of entire chromosomes.…”

Section: Neurosurg Focus / Volume 19 / November 2005mentioning

confidence: 99%

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Molecular cytogenetic analysis in the study of brain tumors: findings and applications

Bayani¹,

Pandita²,

Squire³

2005

FOC

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Classic cytogenetics has evolved from black and white to technicolor images of chromosomes as a result of advances in fluorescence in situ hybridization (FISH) techniques, and is now called molecular cytogenetics. Improvements in the quality and diversity of probes suitable for FISH, coupled with advances in computerized image analysis, now permit the genome or tissue of interest to be analyzed in detail on a glass slide. It is evident that the growing list of options for cytogenetic analysis has improved the understanding of chromosomal changes in disease initiation, progression, and response to treatment. The contributions of classic and molecular cytogenetics to the study of brain tumors have provided scientists and clinicians alike with new avenues for investigation. In this review the authors summarize the contributions of molecular cytogenetics to the study of brain tumors, encompassing the findings of classic cytogenetics, interphase- and metaphase-based FISH studies, spectral karyotyping, and metaphase- and array-based comparative genomic hybridization. In addition, this review also details the role of molecular cytogenetic techniques in other aspects of understanding the pathogenesis of brain tumors, including xenograft, cancer stem cell, and telomere length studies.

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“…The fourth ventricle is the most common location for ependymomas. Cellular and anaplastic ependymoma are WHO grades II and III, respectively (12). Despite in vivo MRS spectra from both cellular and anaplastic ependymomas exhibiting considerable heterogeneity, their metabolic common profile include lower relative levels of N-acetyl-aspartate (NAA) in comparison to other tumours (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Comparative metabolic profiling of paediatric ependymoma, medulloblastoma and pilocytic astrocytoma

Cuellar-Baena

Morales²,

Martinetto³

et al. 2010

Int J Mol Med

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Abstract. Brain tumours are the most common solid tumours in children and a major cause of childhood mortality. The most common paediatric brain tumours include ependymomas, cerebellar astrocytomas and medulloblastomas. These brain tumours are highly heterogeneous regarding their histology, prognosis and therapeutic response. Subtle biochemical changes can be detected in intact tissues by High-Resolution Proton Magnetic Angle Spinning Spectroscopy (HR-MAS) revealing the status of tumour microheterogeneity and metabolic alterations before they are morphologically detectable. In this study, we present metabolic profiles by HR-MAS of 20 intact tissue samples from paediatric brain tumours. Tumour types include ependymoma, medulloblastoma and pilocytic astrocytoma. The metabolic characterization of paediatric brain tumour tissue by HR-MAS spectroscopy provided differential patterns for these tumours. The metabolic composition of the tumour tissue was highly consistent with previous in vivo and ex vivo studies. Some resonances detected in this work and not previously observed by in vivo spectroscopy also show potential in determining tumour type and grade (fatty acids, phenylalanine, glutamate). Overall, this work suggests that the additional information obtained by NMR metabolic profiling applied to tissue from paediatric brain tumours may be useful for assessing tumour grade and determining optimum treatment strategies.

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Ependymoma

Abstract: This review article examines the current status of histopathological and cytogenetic diagnosis, surgical, chemotherapeutic and radiotherapeutic treatment and future directions.

Cited by 53 publications

References 99 publications

Identification of Gains on 1q and Epidermal Growth Factor Receptor Overexpression as Independent Prognostic Markers in Intracranial Ependymoma

Identification of Gains on 1q and Epidermal Growth Factor Receptor Overexpression as Independent Prognostic Markers in Intracranial Ependymoma

Molecular cytogenetic analysis in the study of brain tumors: findings and applications

Comparative metabolic profiling of paediatric ependymoma, medulloblastoma and pilocytic astrocytoma

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