Ependymoma of the sella turcica: a variant of pituicytoma

Scheithauer, Bernd W.; Swearingen, Brooke; Whyte, Elizabeth; Auluck, Pavan K.; Stemmer‐Rachamimov, Anat

doi:10.1016/j.humpath.2008.08.013

Cited by 44 publications

(44 citation statements)

References 29 publications

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“…The rare sellar ependymomas represent yet another differential diagnostically appealing variation on the biphasic architectural theme [24]. Indeed, the radial arrays of tumor cells along round to slit-like lumina in our case readily call to mind ependymal tubules or contorted pseudoventricular cavities.…”

Section: Discussionmentioning

confidence: 72%

Spindle cell oncocytoma of the pituitary gland with follicle-like component: organotypic differentiation to support its origin from folliculo-stellate cells

et al. 2011

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Spindle cell oncocytoma (SCO) is a rare, nonadenomatous tumor originating from the anterior pituitary gland. Composed of fusiform, mitochondrion-rich cells sharing several immunophenotypic and ultrastructural properties with folliculo-stellate cells (FSC), SCO has been proposed to represent a neoplastic counterpart of the latter. To date, however, SCO has failed to meet one criterion commonly used in histological-based taxonomy and diagnostics; that of recapitulating any of FSCs' morphologically defined developmental or physiological states. We describe a unique example of SCO wherein a conventional fascicular texture was seen coexisting with and organically merging into follicle-like arrangements. The sellar tumor of 2.7 9 2.6 9 2.5 cm was transphenoidally resected from a 55-year old female. Preoperative magnetic resonance imaging indicated an isointense, contrast enhancing mass with suprasellar extension. Histology showed multiple rudimentary to well-formed, follicle-like cavities on a classical spindle cell background; while all the participating cells exhibited an SCO immunophenotype, including positivity for S100 protein, vimentin, EMA, Bcl-2, and TTF-1, as well as staining with the antimitochondrial antibody 113-1. Conversely no expression of GFAP, follicular-epithelial cytokeratin, carcinoembryonic antigen, or anterior pituitary hormones was detected. Ultrastructurally, tumor cells facing follicular lumina displayed organelles of epithelial specialization, in particular surface microvilli and apical tight junctions. This constellation is felt to be reminiscent of FSCs' metaplastic transition to follicular epithelium, as observed during embryonic development and physiological renewal of the hormone-secreting parenchyma. Such finding is apt to being read as a supporting argument for SCO's descent from the FSC lineage.

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Section: Discussionmentioning

confidence: 72%

Spindle cell oncocytoma of the pituitary gland with follicle-like component: organotypic differentiation to support its origin from folliculo-stellate cells

et al. 2011

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“…Albeit uncommon, there are several primary intrasellar nonendocrine neoplasms that have been described to have oncocytic, epithelioid and/or papillary histologic features, including: spindle cell oncocytoma (Singh et al, 2012), pituicytoma (Ellis et al, 2012), ependymoma (Kleinman, Zagzag, & Miller, 2003;Scheithauer, Swearingen, Whyte, Auluck, & Stemmer-Rachamimov, 2009;, meningioma, choroid plexus papilloma (Bian et al, 2011;Diengdoh & Shaw, 1993), and oncocytic neoplasms arising from salivary gland rests in the pituitary (Hampton et al, 1997). A pigmented papillary epithelial neoplasm of the pituitary fossa with oncocytic and papillary regions has also been described (Bian et al, 2011); however our case lacked pigmentation of the neoplastic cells.…”

Section: Discussionmentioning

confidence: 64%

An Unusual Oncocytic Sellar Neoplasm in a Patient with Birt-Hogg-Dubé Syndrome

Ryu¹,

Hamilton²,

Starreveld³

et al. 2015

IJN

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Spindle cell oncocytoma (SCO) is a rare and recently described neoplasm arising from the pituitary adenohypophysis thought to be derived from the folliculostellate cells. Even though SCO has been classified as a distinct World Health Organization (WHO) grade I tumor, sellar neoplasms with an oncocytic appearance are uncommon and have a wide differential diagnosis that includes primary and metastatic lesions. Herein we describe an oncocytic sellar neoplasm of uncertain histiogenesis arising in a 49-year-old man with BirtHogg-Dubé (BHD) syndrome. This case is also unusual in that individuals with BHD have a propensity to develop oncocytomas, yet to the best of our knowledge this is the first occurrence of a primary oncocytic neoplasm of the sella in BHD syndrome.

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“…Various cases of ependymoma have been reported in patients older than 60 years, 1,6,20,[23][24][25][26]28) but only three cases of fourth ventricle ependymoma in patients older than 60 years of age, 1,20,23) and ependymomas in older women are particularly rare. 22) The present case and the 8 previous cases of ependymoma in the elderly are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…5,22) By contrast, intracranial ependymoma is a relatively uncommon tumor in adults, 2,10) and is even more infrequent in the elderly. 1,6,20,[23][24][25][26]28) Moreover, geriatric fourth ventricle ependymoma is particularly rare, with only a few reported cases. 1,20,23) We present a case of fourth ventricle ependymoma in an old woman, and describe the clinical, histological, and genetic features.…”

Section: Introductionmentioning

confidence: 99%

Clinical, Histological, and Genetic Features of Fourth Ventricle Ependymoma in the Elderly

Hayashi

Inamasu

Kanai

et al. 2012

Neurol. Med. Chir.(Tokyo)

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A 71-year-old woman presented with a rare case of geriatric ependymoma originating from the fourth ventricle manifesting as progressive gait and memory disturbance. Imaging studies revealed an extraaxial mass in the fourth ventricle protruding into the right cerebellomedullary cistern, with concomitant obstructive hydrocephalus. Surgery achieved subtotal removal since the tumor tightly adhered to the right vestibular area of the fourth ventricular floor. The histological diagnosis was ependymoma, which was also confirmed by comparative genetic hybridization. Although she developed severe laryngeal edema and worsening of the hydrocephalus postoperatively which required additional treatment, she recovered with residual mild gait disturbance, and was transferred to a rehabilitation facility. Fourth ventricle ependymoma in the elderly is rare. Comparative genetic hybridization may be important in the diagnosis of geriatric ependymoma and in the choice for adjuvant therapy as well as in estimating the prognosis for patients with rare types of ependymoma.

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Ependymoma of the sella turcica: a variant of pituicytoma

Cited by 44 publications

References 29 publications

Spindle cell oncocytoma of the pituitary gland with follicle-like component: organotypic differentiation to support its origin from folliculo-stellate cells

Spindle cell oncocytoma of the pituitary gland with follicle-like component: organotypic differentiation to support its origin from folliculo-stellate cells

An Unusual Oncocytic Sellar Neoplasm in a Patient with Birt-Hogg-Dubé Syndrome

Clinical, Histological, and Genetic Features of Fourth Ventricle Ependymoma in the Elderly

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