Ependymomas induced in Hamsters inoculated with an Avian Adenovirus (CELO)

Mancini, L; Yates, Vance J.; Jasty, V.; Anderson, Jeffrey P.

doi:10.1038/222190a0

Cited by 23 publications

(7 citation statements)

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“…Initially only a well differentiated fibrosarcoma at the site of inoculation was reported (Sarma et al, 1965), but subsequently hepatomas (Anderson et al, 1971a), ependymonas (Mancini et al, 1969), adenocarcinomas and hepatomas (Stenback et al, 1973) and other types of sarcoma (Jones et al, 1970) have been described. In vitro transformation of human and hamster cells have also been reported (Anderson et al, 1969a and b).…”

Section: Oncogenicity Of Fowl Adenovirusesmentioning

confidence: 99%

Avian adenoviruses ‐ a review

1977

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Section: Oncogenicity Of Fowl Adenovirusesmentioning

confidence: 99%

Avian adenoviruses ‐ a review

1977

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“…Among these viruses, the Simian adenovirus (SA7) is capable of inducing both ependymomas and malignant choroid plexus papillomas, after intracerebral inoculation to rats and Syrian hamsters (11). The chick embryo lethal orphan virus (CELO) is an avian adenovirus that can also induce intraventricular tumors in newborn Syrian hamsters (12) and although intraventricular location has led to their classification as malignant ependymomas, the ultrastructural features of these tumors are more similar to those of choroid plexus papillomas.…”

Section: Virus-induced Ependymomatous Tumorsmentioning

confidence: 99%

Ependymoma Models

Vaquero¹,

Zurita²

2012

Neuromethods

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Experimental neurocarcinogenesis using chemical agents or certain viruses can get brain tumors; some of them have been considered classically as ependymomas according to their histological aspects. However, it is now accepted that these tumors do not meet a clear criteria to be considered as ependymoma models. Xenografts of human ependymomas in nude mouse are most useful models, but they have the disadvantage that the absence of host immune response may mask important aspects currently considered in the biology of brain tumors.

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“…Adenoviruses have also been reported to induce hydrocephalus in hamsters following neonatal intracerebral inoculation. Mancini et al (1969) noted severe hydrocephalus in several hamsters with ependymomas induced by an avian adenovirus.…”

Section: Obstruction Of Cerebrospinal-huid Pathways By Viral Inflammamentioning

confidence: 99%

Hydrocephalus and Viral Infections

Johnson

1975

Develop Med Child Neuro

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SUMMARY In the study of virus‐induced hydrocephalus in experimental animals, a surprising finding has been that while a number of viruses do not cause acute clinical disease, they do affect ependymal cells and this results later in non‐inflammatory aqueductal stenosis. This finding supports the hypothesis that aqueductal stenosis results from injury to a normally developed structure and suggests that viral infections are a potential cause of this ‘developmental’ defect. RÉSUMÉ Hydrocéphalic et infection virale Dans l'étude de l'hydrocéphalie induite par virus chez l'animal d'expérience, un point surprenant a été la découverte que nombre de virus qui ne provoquent pas d'affections cliniques aigues altèrent les cellules épendymales avec comme conséquence ultérieure une sténose non inflammatoire de l'aqueduc. Ce fait renforce l'hypothèse que la sténose de l'aqueduc provient d'une agression sur une structure normalement développée et suggère que les infections virales sont une cause potentielle de ce défaut de ‘développement’. ZUSAMMENFASSUNG Hydrocephalus und virale Infektionen Bei der tierexperimentellen Studie über virusinduzierten Hydrocephalus ergab sich ein überraschender Befund: Während eine Anzahl Viren zwar keine akute klinische Erkrankung verursachen, betreffen sie doch die ependymalen Zellen; das resultiert später in einer nichtentzündlichen Aquäduktstenose. Dieser Befund stützt die Hypothese, daß die Aquäduktstenose durch die Schädigung einer normal entwickelten Struktur entsteht, und läßt vermuten, daß virale Infektionen eine mögliche Usache dieses ‘Entwicklungs’‐Defekts sind. RESUMEN Hidrocefalia e infecciones virales En el estudio de la hidrocefalia inducida por virus en animales, un hallazgo sorprendente ha sido que mientras un número de virus no causa ninguna enfermedad clínica aguda, en cambio afectan las cé1ulas ependimarias, con el resultado posterior de una estenosis no inflamatoria del acueducto. Estos hallazgos apoyan la hipótesis de que la estenosis de acueducto resulta de una acción nociva sobre una estructura desarrollada normalmente y sugiere que las infecciones virales son una causa potencial de este defecto de ‘desarrollo’.

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Ependymomas induced in Hamsters inoculated with an Avian Adenovirus (CELO)

Cited by 23 publications

References 4 publications

Avian adenoviruses ‐ a review

Avian adenoviruses ‐ a review

Ependymoma Models

Hydrocephalus and Viral Infections

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