2008
DOI: 10.1677/joe-08-0084
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Eph receptors and zonation in the rat adrenal cortex

Abstract: Although the zonation of the adrenal cortex has a clear functional role, the mechanisms that maintain it remain largely conjectural. The concept that an outer proliferative layer gives rise to cells that migrate inwards, adopting sequentially the zona glomerulosa, fasciculata and reticularis phenotypes, has yet to be explained mechanistically. In other tissues, Eph receptor (EphR)/ephrin signalling provides a mechanism for cellular orientation and migration patterns. Real-time PCR and other methods were used t… Show more

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Cited by 10 publications
(7 citation statements)
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“…Functional adrenal zonation has been studied extensively in rodents, with the major sites of adrenocortical proliferation described as the stem cell zone, progenitor cell zone, undifferentiated cell zone, intermediate zone, and undifferentiated zona glomerulosa (Mitani et al 1994;Mitani et al 2003;Peters et al 1998;McNeill et al 2005;Brennan et al 2008). The results of the present study in humans suggest that the zP in humans has a major role in bidirectional differentiation into either the zG or the zF according to the endocrinological environment, rather than in relation to cellular proliferative activity.…”
Section: Discussionmentioning
confidence: 67%
“…Functional adrenal zonation has been studied extensively in rodents, with the major sites of adrenocortical proliferation described as the stem cell zone, progenitor cell zone, undifferentiated cell zone, intermediate zone, and undifferentiated zona glomerulosa (Mitani et al 1994;Mitani et al 2003;Peters et al 1998;McNeill et al 2005;Brennan et al 2008). The results of the present study in humans suggest that the zP in humans has a major role in bidirectional differentiation into either the zG or the zF according to the endocrinological environment, rather than in relation to cellular proliferative activity.…”
Section: Discussionmentioning
confidence: 67%
“…Among these are ephrins (EphA) and their receptors, which are mainly present in the ZG. Interestingly, the level of expression of EphA2 closely correlates with changes in the ZG phenotype, in particular it is increased in animals on a low-sodium diet (which increases ZG size), but decreased by ACTH treatment (which increases ZF size) (Brennan et al 2008). Another family of extracellular matrix proteins, thrombospondins, is expressed in bovine adrenal glands, with thrombospondin 2 (TSP2) promoting cell attachment but preventing spreading of adrenocortical cells in primary culture (Feige et al 1998).…”
Section: Involvement Of Mapk Pathwaysmentioning
confidence: 99%
“…The Eph/ephrin forward-reverse signaling system provides a possible mechanism for such cellular orientation and migration within the zones, and elements of the system have been demonstrated in the rat adrenal cortex. In particular, EphA2 is strongly transcribed in the rat glomerulosa, and responds to the physiological stimuli of a low sodium diet, captopril, or betamethasone treatment in a manner that suggests association with cell phenotype (Brennan et al, 2008 ).…”
Section: Maintenance Of Zonal Differentiationmentioning
confidence: 99%