2017
DOI: 10.36076/ppj.2017.e574
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EphrinB-EphB Signaling Induces Hyperalgesia through ERK5/CREB Pathway in Rats

Abstract: Background: There are numerous studies implicating that EphB receptors and ephrinB ligands play important roles in modulating the transduction of spinal nociceptive information. EphrinB-EphB signaling may contribute to hyperalgesia via various kinds of downstream molecules, the mechanisms of which have not been completely understood. Objective: The aim of the present study was to identify whether ephrinB-EphB signaling could contribute to hyperalgesia through ERK5/CREB pathway. Study Design: Controlled animal … Show more

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Cited by 6 publications
(1 citation statement)
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“…ERK5 is activated in spinal nerve injury. Intrathecal injection of ERK5 antisense oligodeoxynucleotides can alleviate neuropathic pain [ 18 ]. As the downstream target of ERK5, CREB plays a key role in the occurrence and development of neuropathic pain by regulating the transcription and secretion of a variety of neurotransmitters.…”
Section: Discussionmentioning
confidence: 99%
“…ERK5 is activated in spinal nerve injury. Intrathecal injection of ERK5 antisense oligodeoxynucleotides can alleviate neuropathic pain [ 18 ]. As the downstream target of ERK5, CREB plays a key role in the occurrence and development of neuropathic pain by regulating the transcription and secretion of a variety of neurotransmitters.…”
Section: Discussionmentioning
confidence: 99%