Epi-miRNAs: Regulators of the Histone Modification Machinery in Human Cancer

Mortazavi, Deniz; Sohrabi, Behnoush; Mosallaei, Meysam; Nariman‐Saleh‐Fam, Ziba; Bastami, Milad; Mansoori, Yaser; Daraei, Abdolreza; Vahed, Sepideh Zununi; Navid, Shadan; Saadatian, Zahra; Jamialahmadi, Tannaz; Teng, Yong; Sahebkar, Amirhossein

doi:10.1155/2022/4889807

Cited by 15 publications

(12 citation statements)

References 261 publications

(278 reference statements)

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“…Histone modifications are another key mechanism of epigenetics. MicroRNAs have been shown to regulate gene expression by modulating histone modification via the targeting of histone acetyltransferases (HATs), histone deacetylases (HDACs), histone methyltransferases (HMTs), histone demethylases, histone kinases and histone phosphatases, as well as by modulating histone desumoylation [ 34 ]. On the other hand, expression of miRNAs is also regulated by histone modifications.…”

Section: Non-coding Rnasmentioning

confidence: 99%

Non-Coding RNAs Modulating Estrogen Signaling and Response to Endocrine Therapy in Breast Cancer

Treeck¹,

Ortmann²

2023

Cancers

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The largest part of human DNA is transcribed into RNA that does not code for proteins. These non-coding RNAs (ncRNAs) are key regulators of protein-coding gene expression and have been shown to play important roles in health, disease and therapy response. Today, endocrine therapy of ERα-positive breast cancer (BC) is a successful treatment approach, but resistance to this therapy is a major clinical problem. Therefore, a deeper understanding of resistance mechanisms is important to overcome this resistance. An increasing amount of evidence demonstrate that ncRNAs affect the response to endocrine therapy. Thus, ncRNAs are considered versatile biomarkers to predict or monitor therapy response. In this review article, we intend to give a summary and update on the effects of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) on estrogen signaling in BC cells, this pathway being the target of endocrine therapy, and their role in therapy resistance. For this purpose, we reviewed articles on these topics listed in the PubMed database. Finally, we provide an assessment regarding the clinical use of these ncRNA types, particularly their circulating forms, as predictive BC biomarkers and their potential role as therapy targets to overcome endocrine resistance.

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Section: Non-coding Rnasmentioning

confidence: 99%

Non-Coding RNAs Modulating Estrogen Signaling and Response to Endocrine Therapy in Breast Cancer

Treeck¹,

Ortmann²

2023

Cancers

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“…Social conditions impact health in multiple capacities that range from well-being to cellular-level processes ( Figure 1 ). Established biological pathways of social experiences include inflammation [ 23 ], telomere lengths [ 24 ], allostatic load [ 25 , 26 ], epigenetic changes [ 27 ] such as DNA methylation, histone modifications, and micro-RNA regulation [ 28 , 29 ]. The weathering hypothesis posits a theoretical framework that centers the allostatic load to be the chronic burden of social positionality across the lifespan as the underpinning of health inequality [ 26 , 30 ].…”

Section: Biological Pathways Of Social Experiencesmentioning

confidence: 99%

Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences

Valencia

Gachupin

Molina

et al. 2022

IJERPH

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The objective of this article is to call for integrating biological pathways of social experiences in the concept model of cancer disparities and social determinants of health (SDH) fields. Black, Indigenous, and People of Color (BIPOC) populations experience more negative outcomes across the cancer continuum. Social conditions are instrumental in better understanding the contemporary and historical constructs that create these patterns of disparities. There is an equally important body of evidence that points to the ways that social conditions shape biological pathways. To date, these areas of research are, for the most part, separate. This paper calls for a bridging of these two areas of research to create new directions for the field of cancer disparities. We discuss inflammation, epigenetic changes, co-morbidities, and early onset as examples of the biological consequences of social conditions that BIPOC populations experience throughout their lifespan that may contribute to disproportionate tumorigenesis and tumor progression.

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“…miRNAs are involved in the regulation of those epigenetic mechanisms that play an important role in early stages of leukemogenesis [ 81 , 82 ]. According to a prominent body of evidence, these so-called epi-miRNAs are implicated in the regulation of both DNA-methylation and histone modification [ 82 , 83 ].…”

Section: Implication Of Mirnas In Carcinogenesis and Leukemogenesismentioning

confidence: 99%

Implication of microRNAs in Carcinogenesis with Emphasis on Hematological Malignancies and Clinical Translation

Gaál

2022

IJMS

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MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs, that are involved in the multistep process of carcinogenesis, contributing to all established hallmarks of cancer. In this review, implications of miRNAs in hematological malignancies and their clinical utilization fields are discussed. As components of the complex regulatory network of gene expression, influenced by the tissue microenvironment and epigenetic modifiers, miRNAs are “micromanagers” of all physiological processes including the regulation of hematopoiesis and metabolic pathways. Dysregulated miRNA expression levels contribute to both the initiation and progression of acute leukemias, the metabolic reprogramming of malignantly transformed hematopoietic precursors, and to the development of chemoresistance. Since they are highly stable and can be easily quantified in body fluids and tissue specimens, miRNAs are promising biomarkers for the early detection of hematological malignancies. Besides novel opportunities for differential diagnosis, miRNAs can contribute to advanced chemoresistance prediction and prognostic stratification of acute leukemias. Synthetic oligonucleotides and delivery vehicles aim the therapeutic modulation of miRNA expression levels. However, major challenges such as efficient delivery to specific locations, differences of miRNA expression patterns between pediatric and adult hematological malignancies, and potential side effects of miRNA-based therapies should be considered.

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Epi-miRNAs: Regulators of the Histone Modification Machinery in Human Cancer

Cited by 15 publications

References 261 publications

Non-Coding RNAs Modulating Estrogen Signaling and Response to Endocrine Therapy in Breast Cancer

Non-Coding RNAs Modulating Estrogen Signaling and Response to Endocrine Therapy in Breast Cancer

Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences

Implication of microRNAs in Carcinogenesis with Emphasis on Hematological Malignancies and Clinical Translation

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