Epi-perineurial anatomy, innervation, and axonal nociceptive mechanisms

Bove, Geoffrey M.

doi:10.1016/j.jbmt.2008.03.004

Cited by 43 publications

(25 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cervical whiplash may also influence intervertebral discs, muscles, facet joints and ligaments, which may irritate surrounding nerve roots [2]. Therefore, neural responses and dysesthetic pain can appear in the absence of apparent nerve fibre or tissue damage [3].…”

Section: Introductionmentioning

confidence: 99%

Short-term changes in median nerve neural tension after a suboccipital muscle inhibition technique in subjects with cervical whiplash: a randomised controlled trial

et al. 2014

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Short-term changes in median nerve neural tension after a suboccipital muscle inhibition technique in subjects with cervical whiplash: a randomised controlled trial

et al. 2014

View full text Add to dashboard Cite

“…This was noted mainly in the peri and epineurium, where strong and intact nerve appears as dense layers, which give the nerve support, cushioning and resistance to tension (Bové, 2008;Mizisin & Weerasuriya, 2011;Yegiyants et al). These factors contributed to integrating the most robust cross -sectional area identified in the Control Group.…”

Section: Groupsmentioning

confidence: 97%

Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental Neurotmesis

et al. 2015

View full text Add to dashboard Cite

capacity and histomorphometric changes in rat sciatic nerve following experimental neurotmesis. Int. J. Morphol., 33(2):777-781, 2015. SUMMARY:Through a wide range of cellular and molecular events, the peripheral nervous system is endowed with great regenerative capacity, responding immediately to injuries that occur along the length of the nerve. The aim of this study was to histomorphometrically assess the degree of maturity of the nervous tissue and possible microscopic changes in newly formed nerve segments 60 days after experimental neurotmesis of the sciatic nerve in rats. Control Group (CG) and an Injury Group (IG) were used. IG underwent neurotmesis of the sciatic nerve of the right foot, with immediate surgical repair using the tubulization technique. 60 days following experimental surgery, animals from both groups had their sciatic nerves collected for histomorphometric analysis. Statistical analysis was performed, using the Student t-test for independent samples, expressed as mean ± standard deviation, with 5% significance. In the event of injury, peripheral nerve tissue is mobilized in an intrinsic self-healing process. 60 days following of nerve regeneration in neurotmesis injury, the peripheral nerve presents a segment joining the newly formed neural stump. The new stump has a number of regenerated axons compatible with an intact nerve, but which still show great immaturity in the axonal structural layers of the nerve.

show abstract

“…Nervous trunks are mechano-sensitive because their connective tissue has afferents normally participating in mechano-reception 22,23 . Peripheral nerves are innervated by neurovegetative fibers, the nervi vasorum, and by intrinsic nerves, the nervi nervorum, made up of unmyelinated or thin myelinated fibers composing a thin plexus layer of free nervous terminations in the epineurium, perineurium and endoneurium and some encapsulated Pacini terminations in the endoneurium 16,[22][23][24][25][26] . In late 19 th century, John Marshall, mentioned by Powell 27 , and neurosurgeon Victor Horsley, mentioned by Sugar 28 , both English citizens, have evaluated histological features of peripheral nerves and have observed nervous ramifications in the epineurium coming from the nerve itself, the nervi nervorum.…”

Section: Organization Of Peripheral Nociceptive Nervous Systemmentioning

confidence: 99%

Concept of acute neuropathic pain. The role of nervi nervorum in the distinction between acute nociceptive and neuropathic pain

Teixeira

Almeida²,

Yeng

2016

Revista Dor

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVES:Several pathophysiological mechanisms are involved in the genesis of neuropathic pain. However, available justifications for its onset are unsatisfying and do not explain the participation of nervi nervorum and nervi vasorum abnormalities on functional aberrations which characterize pain generated by injuries to the peripheral nervous system. There are evidences that nervi nervorum contribute to the development and justify many clinical findings and prophylactic, therapeutic and rehabilitation alternatives related to neuropathic pain. This study aimed at presenting a review of anatomic and functional studies and theories about their objectives and at giving examples of conditions in which nervi nervorum have markedly participated in neuropathic pain generation and maintenance. CONTENTS: Nervi nervorum are a set of unmyelinated or poorly myelinated fibers located in peripheral nerves sheaths which, among other functions, seem to participate in the transmission of evoked sensory information and in the environmental regulation of peripheral nervous system structures. CONCLUSION: Nervi nervorum structural and functional abnormalities may contribute to the onset, maintenance and worsening of neuropathic pain and "demodulatory" painful syndromes. Further studies, especially with the application of more specific and sensitive histological, biochemical and electrophysiological methods are necessary to clarify the realities of their biologies. Keywords: Nervi nervorum, Neuropathic pain, Nociceptive pain, Pathophysiology, Peripheral nerves. RESUMO JUSTIFICATIVA E OBJETIVOS:Diversos mecanismos fisiopatológicos estão envolvidos na gênese das dores neuropáticas. Entretanto as justificativas disponíveis para sua ocorrência são insatisfatórias e em nada esclarecem a ocorrência das assim chamadas dores desmodulatórias. Há crescente interesse em se compreender a participação das anormalidades dos nervi nervorum e nervi vasorum nas aberrações funcionais que caracterizam as dores geradas pelas lesões que acometem o sistema nervoso periférico. Há evidências de que os nervi nervorum contribuem para desenvolvimento e justificam muitos dos achados clínicos e as alternativas profiláticas, terapêuticas e reabilitacionais relacionadas às dores neuropáticas. O objetivo deste estudo foi apresentar uma revisão sobre os estudos anatômicos e funcionais e as teorias sobre suas finalidades e exemplificar condições em que os nervi nervorum participam de modo marcante na sua geração e manutenção da dor neuropática. CONTEÚDO: Os nervi nervorum são um conjunto de fibras amielínicas ou pouco mielinizadas localizadas nas bainhas dos nervos periféricos que, dentre outras funções, parecem participar da veiculação de informações sensitivas evocaConcept of acute neuropathic pain. The role of nervi nervorum in the distinction between acute nociceptive and neuropathic pain INTRODUCTIONAccording to the International Association for the Study of Pain (IASP) definition, pain is "an unpleasant sensory and emotional experienc...

show abstract

Epi-perineurial anatomy, innervation, and axonal nociceptive mechanisms

Cited by 43 publications

References 15 publications

Short-term changes in median nerve neural tension after a suboccipital muscle inhibition technique in subjects with cervical whiplash: a randomised controlled trial

Short-term changes in median nerve neural tension after a suboccipital muscle inhibition technique in subjects with cervical whiplash: a randomised controlled trial

Regenerative Capacity and Histomorphometric Changes in Rat Sciatic Nerve Following Experimental Neurotmesis

Concept of acute neuropathic pain. The role of nervi nervorum in the distinction between acute nociceptive and neuropathic pain

Contact Info

Product

Resources

About