Epibulbar Nodular Fasciitis

Massop, David John; Frederick, Paul A.; Li, He J.; Lin, Amy

doi:10.1159/000445974

Cited by 6 publications

(6 citation statements)

References 14 publications

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“…Nodular fasciitis most commonly appears to affect the conjunctiva and the eyelids rather than the orbit 33 . This is a condition characterized by nodular proliferation of fibroblasts surrounded by myxoid tissue with scant infiltration of lymphocytes and mononuclear cells 36,37 unlike the cases here described. Canine reactive histiocytosis is suspected to be secondary to immune dysregulation.…”

Section: Discussionmentioning

confidence: 66%

“…CD3 (B) and CD20 (C) markers revealed a mixed infiltrate of T and B lymphocytes, respectively, but with T cells predominating. Main photo 100× magnification and inset 400× magnification characterized by nodular proliferation of fibroblasts surrounded by myxoid tissue with scant infiltration of lymphocytes and mononuclear cells 36,37 unlike the cases here described. Canine reactive histiocytosis is suspected to be secondary to immune dysregulation.…”

Section: Discussionmentioning

confidence: 66%

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Canine idiopathic orbital inflammation: A case series of four affected dogs (five orbits)

Freitas¹,

Taeymans²,

Knott³

et al. 2022

Veterinary Ophthalmology

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In humans, idiopathic orbital inflammation (IOI) is a diagnosis attributed to benign, inflammatory orbital conditions without identifiable local or systemic cause. We describe the clinical signs, imaging and histopathological findings, management and outcome of four dogs diagnosed with IOI. Methods: Multicentric retrospective study.Results: A total of four dogs (five orbits) of three different breeds (three cases were English Springer Spaniels [ESS] or ESS-cross) and ages ranging from 3 to 12 years were included. Initial presenting signs were unilateral and included exophthalmos, enophthalmos, globe deviation, thickening and protrusion of the third eyelid and conjunctival hyperemia. Computed tomography and magnetic resonance imaging identified heterogeneous space-occupying, contrast-enhancing orbital lesions in all cases. Sparing of the retrobulbar space was detected in four of five orbits. Histopathology revealed mixed inflammatory infiltrates of lymphocytes, plasma cells, and histiocytes. Immunohistochemistry was performed in two cases highlighting the presence of histiocytes and lymphocytes, predominantly T cells.Resolution of clinical signs was achieved in two cases managed with oral immunosuppressant medication (corticosteroids alone or combined with cyclosporine or azathioprine), one went into spontaneous remission, one resolved with topical corticosteroids, and one underwent exenteration. Recurrence occurred in two cases within 15 months of initial diagnosis and required further immunosuppressant medication. One case developed signs in the contralateral orbit within 8 months of presentation.Conclusions: IOI is an uncommon condition in dogs. Its diagnosis relies on the combination of advanced imaging and histology. As in humans, it appears that spontaneous remission and recurrence may occur requiring long-term immunosuppressant medication.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 66%

Canine idiopathic orbital inflammation: A case series of four affected dogs (five orbits)

Freitas¹,

Taeymans²,

Knott³

et al. 2022

Veterinary Ophthalmology

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“…35 A total of 151 patients were asymptomatic, 3 suffered from pain 36 and 11 suffered from accessory symptoms, like diplopia, blurred vision, trismus, dyspnoea, proptosis, fever, masticatory deficiency and otorrhoea. 2,4,19,26,31,33,[36][37][38][39][40] The nodular fasciitis localization can be ubiquitous but certain regions are more frequently involved. The neck region is the most common site (53 cases out of 166, 32%) followed by the cheek region (22 cases, 13%), parotid gland (17 cases, 10%) and orbital region (14 cases, 9%).…”

Section: Discussionsmentioning

confidence: 99%

“…In 14 out of the 53 articles, the authors specified the nodular fasciitis subtype identifying: 5 cases of subcutaneous fasciitis, 7,10,27–29 4 cases of cranial fasciitis, 14,22,23,30,31 3 cases of intravascular fasciitis, 8,32,33 1 case of periosteal fasciitis 34 and 1 case of subepithelial myxoid fasciitis 35 . A total of 151 patients were asymptomatic, 3 suffered from pain 36 and 11 suffered from accessory symptoms, like diplopia, blurred vision, trismus, dyspnoea, proptosis, fever, masticatory deficiency and otorrhoea 2,4,19,26,31,33,36–40 …”

Section: Discussionmentioning

confidence: 99%

“…The nodular fasciitis diagnosis was generally based on a CT scan, sometimes associated with an MRI scan, ultrasound image and/or incisional biopsy. The gold standard therapy is surgical resection as documented by the literature 1,2,5–59 . In five cases, the authors preferred a wait‐and‐see approach, 3,11,60,61 while in another seven cases, the authors reported a spontaneous regression of the pathology 42 .…”

Section: Discussionmentioning

confidence: 99%

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Nodular fasciitis in cervicofacial region: a rare case description and literature review

Abbate¹,

Orabona²,

Audino³

et al. 2021

Oral Surgery

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Nodular fasciitis is a relatively rare pathology, first described by Konwaler in 1955, which derives from an uncontrolled fibroblastic proliferation. Many authors have described this pathology in the literature, considering previous trauma as a predisposing condition. It predominantly afflicts males between the 2nd and 4th decade of life. A rapid growth, high cellularity and infiltrative borders are the main characteristics of this fasciitis. Even though it can be ubiquitous, the head and neck regions are affected in about 13–37% of cases. The symptoms and signs depend on the localization and size of the neoplasm in relation to the surrounding noble structures, which can suffer on account of the compressive action of the mass. The gold standard treatment is surgical removal. In a very few cases, local recurrences have been described. In this article, we present a case treated by means of a minimally invasive, endoscopically assisted, surgical approach, together with providing a comprehensive literature review that collects data about all the cases afflicting the cervicofacial region described to date. To the best of our knowledge, this is the first case of nodular fasciitis located in the submandibular region approached via an endoscopically assisted, minimally invasive, surgical technique.

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Conjunctival Stromal Tumors

Pe’er

Frenkel

2019

Clinical Ophthalmic Oncology

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Epibulbar Nodular Fasciitis

Cited by 6 publications

References 14 publications

Canine idiopathic orbital inflammation: A case series of four affected dogs (five orbits)

Canine idiopathic orbital inflammation: A case series of four affected dogs (five orbits)

Nodular fasciitis in cervicofacial region: a rare case description and literature review

Conjunctival Stromal Tumors

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