Epicardial adipose tissue and its association to plasma adrenomedullin levels in patients with metabolic syndrome

Torres, Christopher; Lima-Martínez, Marcos M.; Rosa, Francisco; Guerra, Ernesto; Paoli, Mariela; Iacobellis, Gianluca; Rodney, Marianela; Romero-Vecchione, Eduardo; Saadtjian, Maria Luisa; Zagala, Moisés; Rodney, Henry

doi:10.1016/j.endoen.2011.06.002

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…This is the first study to examine plasma bio-ADM levels among BRCA mutation carriers. In line with previous studies among the general population 44 , high bio-ADM levels were associated with traditional cardiovascular risk factors, including age 45 , BMI 45 , insulin resistance 46 , 47 , metabolic syndrome 48 , low cardiorespiratory fitness 49 and smoking 20 , 50 . Central obesity (as measured by the waist-to-hip-ratio), rather than general obesity (as measured by BMI), was a strong predictor for high bio-ADM levels which corresponds to other investigations suggesting that adipose tissue is a major source of ADM 51 , 52 , 53 .…”

Section: Discussionsupporting

confidence: 88%

Associations of Plasma Bioactive Adrenomedullin Levels with Cardiovascular Risk Factors in BRCA1/2 Mutation Carriers

Lammert

Basrai

Struck³

et al. 2022

Geburtshilfe Frauenheilkd

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Background Cardiovascular disease (CVD) is an important cause of morbidity and mortality in breast cancer survivors. Effective screening modalities to identify CVD risk are lacking in this population. Adrenomedullin (ADM) has been suggested as a biomarker for subclinical cardiac dysfunction in the general population. Levels of ADM have been proven to be responsive to lifestyle changes that lead to improved cardiovascular health. As BRCA1/2 mutation carriers are deemed to be at an increased risk for CVD, the aim of this study was to examine plasma ADM levels in a cohort of BRCA mutation carriers and to assess their association with cardiovascular risk factors. Methods Plasma ADM concentrations were measured in 292 female BRCA1/2 mutation carriers with and without a history of breast cancer. Subjects were classified into high versus low ADM levels based on the median ADM level in the entire cohort (13.8 pg/mL). Logistic regression models were used to estimate the odds ratios (OR) of having elevated ADM levels by several cardiovascular risk factors. Results Of all women (median age: 43 years), 57.5% had a previous diagnosis of breast cancer. The median time between diagnosis and study entry was three years (range: 0 – 32 years). Women presenting with metabolic syndrome had 22-fold increased odds of having elevated ADM levels (p < 0.001). Elevated ADM levels were associated with lower cardiorespiratory fitness (OR = 0.88, p < 0.001) and several parameters of obesity (p < 0.001). ADM levels were higher in women who have ever smoked (OR = 1.72, p = 0.02). ADM levels were not associated with a previous diagnosis of breast cancer (p = 0.28). Conclusions This is the first study in BRCA mutation carriers that has linked circulating ADM levels to traditional cardiovascular risk factors. The long-term clinical implications of these findings are yet to be determined.

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Section: Discussionsupporting

confidence: 88%

Associations of Plasma Bioactive Adrenomedullin Levels with Cardiovascular Risk Factors in BRCA1/2 Mutation Carriers

Lammert

Basrai

Struck³

et al. 2022

Geburtshilfe Frauenheilkd

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“…Our results correspond to those of other studies, which show echocardiographically-measured EAT values linked to anthropometric and clinical metabolic syndrome components (6,8). In fact, some EAT thickness values were found to have a greater significance in the metabolic syndrome group than in the control group (5.69 ± 1.12 vs. 3.52 ± 0.80; p = 0.0001) as well as a significant correlation with BMI and WC, suggestive of obesity as a predisposing factor for epicardial fat.…”

Section: Discussionsupporting

confidence: 80%

“…The strong correlation between LVM and EAT thickness has been characterized by other authors (8,22,23). Several mechanisms might explain this relationship: a) EAT augmentation is associated with hi gher intramyocardial lipid content, and hence, with myocardial steatosis and lipotoxicity, which might induce adverse structural and functional adaptations, including cardiomyopathy (24); b) EAT may affect cardiac morphology by means of the effect, both local and systemic, of the adipocytokines it synthesizes, as some of them are capable of inducing cardiac remodeling (25); c) EAT could induce systemic insulin resistance, which in turn can promote left ventricular hyperthrophy via direct mitogenic action of insulin post-receptor pathway in myocardial cells (2,26).…”

Section: Discussionmentioning

confidence: 80%

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Epicardial adipose tissue thickness and its association with adiponectin in metabolic syndrome patients from Mérida, Venezuela

Lima-Martínez

López-Mendez

Odreman

et al. 2014

Arq Bras Endocrinol Metab

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Objective: To study the relationship between epicardial adipose tissue (EAT) thickness and plasma levels of adiponectin in Venezuelan patients. Subjects and methods: Thirty-one patients diagnosed with metabolic syndrome (study group) and 27 controls were selected and tested for glycemia, lipids, and adiponectin. EAT thickness, ejection fraction, diastolic function, left ventricular mass (LVM), and left atrial volume (LAV) were determined by transthoracic echocardiography. Results: EAT thickness was greater in metabolic syndrome patients (5.69 ± 1.12 vs. RESUMOObjetivo: Estudar a relação entre a espessura do tecido adiposo epicárdico (TAE) e os níveis plasmáticos de adiponectina em pacientes venezuelanos. Sujeitos e métodos: Foram selecionados 31 pacientes com diagnóstico de síndrome metabólica (SM) (grupo de estudo) e 27 controles. Foram medidos a glicose, os lipídios e a adiponectina. Foram determinados a espessura do TAE, a fração de ejeção, a função diastólica, a massa ventricular esquerda (MVE) e o volume atrial esquerdo (VAI) pela ecocardiografia transtorácica. Resultados: A espessura do TAE foi maior em pacientes com SM (5,69 ± 1,12 contra 3,52 ± 0,80 mm; p = 0,0001) com uma correlação positiva com o índice de massa corporal (IMC) (r = 0,661; p = 0,0001), circunferência da cintura (CC) (r = 0,664; p = 0,0001), pressão arterial sistólica (PAS) (r = 0,607; p = 0,0001), diastólica (PAD) (r = 0,447; p = 0,0001), insulina (r = 0,505; p = 0,0001), com a relação TG/HDL-C (r = 0,447; p = 0,0001), com o colesterol HDL (r = 0,353; p = 0,007), VAI (r = 0,432; p = 0,001) e MVI (r = 0,469; p = 0,0001). A espessura do TAE se correlacionou negativamente com a adiponectina (r = -0,499; p = 0,0001). Conclusão: Existe uma relação significativa entre a espessura do TAE, os componentes do SM e a concentração plasmática de adiponectina, o que poderia ser utilizado como um biomarcador para essa doença. Arq Bras Endocrinol Metab. 2014;58(4):352-61 Descritores Tecido adiposo epicárdico; gordura epicárdica; síndrome metabólica; adiponectina; hispânicos

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“…Epicardial adipose tissue (EAT) is a proxy measure for visceral adiposity and visceral fat has been shown to be a reliable predictor of metabolic risk [ 12 ]. An increasing body of research suggests that EAT thickness is linked to traditional anthropometric and clinical factors such as BMI, waist circumference (WC), systolic blood pressure, and diastolic blood pressure [ 13 , 14 ]. The goal of this study was to compare EFT in RA patients to age and sex-matched controls, as well as to determine the variables linked to increased EFT in RA patients.…”

Section: Discussionmentioning

confidence: 99%

Epicardial Fat Thickness: A Cardiometabolic Risk Marker in Rheumatoid Arthritis

Saha¹,

Singh²,

Mir³

et al. 2022

Cureus

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Background: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disorder of unknown etiology which mainly involves synovial joints. However, the corresponding systemic inflammation may result in disorders of multiple other organ systems. Several organs and organ systems are potentially involved in RA, particularly in severe diseases. The organs most involved are the lung, heart, eyes, and nervous system. Extra-articular manifestations of RA may develop even before the onset of arthritis. Emerging epidemiological evidence shows that cardiovascular disease (CVD) accounts for near about 50% of RAassociated death. Epicardial fat thickness (EFT) has recently emerged as a new marker of cardiometabolic risk. Although Epicardial fat (EF) is needed for heart muscle function, given its intrinsic inflammatory status, EFT displays the potential to serve as a therapeutic target in patients with RA.Objectives: To evaluate EFT using echocardiography in RA patients compared to age and sex-matched control and to find the factors associated with EFT in RA patients.

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Epicardial adipose tissue and its association to plasma adrenomedullin levels in patients with metabolic syndrome

Cited by 7 publications

References 29 publications

Associations of Plasma Bioactive Adrenomedullin Levels with Cardiovascular Risk Factors in BRCA1/2 Mutation Carriers

Associations of Plasma Bioactive Adrenomedullin Levels with Cardiovascular Risk Factors in BRCA1/2 Mutation Carriers

Epicardial adipose tissue thickness and its association with adiponectin in metabolic syndrome patients from Mérida, Venezuela

Epicardial Fat Thickness: A Cardiometabolic Risk Marker in Rheumatoid Arthritis

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