Epicardial Adipose Tissue in the General Middle-aged Population and Its Association With Metabolic Syndrome

Calabuig, Álvaro; Barba, J; Guembe, María Jesús; Dı́ez, Javier; Berjón, Jesús; Martínez‐Vila, E.; Irimia, P.; Toledo, Estefanía

doi:10.1016/j.rec.2016.08.001

Cited by 23 publications

(24 citation statements)

References 37 publications

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“…The EAT-rv values found among our sample of the Chinese population were similar to those of South Koreans, 14 but lower than values measured among Caucasians. 15 This racial difference was also confirmed by Fox et al 16 Our results show that EAT thickness was higher in older people and lower in males, a finding which is consistent with a study by Graeff et al 4 Both clinical studies and autopsies confirmed that EAT thickness significantly correlates with aging. 15,17 As for gender difference, our results were consistent with the study by Baragetti et al, 18 but opposite to the study by Calabuig et al 15 This discrepancy could be explained by the fact that the latter study did not include multivariate analysis.…”

Section: Discussionsupporting

confidence: 92%

“…This conclusion is consistent with previous reports. 4,5,15 High-densitylipoprotein cholesterol is a protective factor of EAT thickness, according to our results. In a cross-sectional study of 72 hemodialysis patients, a low HDL cholesterol level was identified as an independent risk factor of elevated EAT thickness.…”

Section: Discussionsupporting

confidence: 81%

“…8 However, the association was reduced when the size of the study population was increased and multivariate analysis was performed. 4,15 In our study, EAT-rv also lacked a significant correlation with metabolic syndrome after multivariate analysis, but EAT-ivg did significantly correlate with metabolic syndrome. In addition, the κ value between EAT-rv and EAV was lower than that of EAT-ivg and EAV, and the AUC for the application of EAT-rv in predicting metabolic syndrome was lower than that of EAT-ivg.…”

Section: Discussionmentioning

confidence: 44%

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A new measurement site for echocardiographic epicardial adipose tissue thickness and its value in predicting metabolic syndrome

et al. 2019

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A new measurement site for echocardiographic epicardial adipose tissue thickness and its value in predicting metabolic syndrome. AbstractBackground. Echocardiographic epicardial adipose tissue (EAT) thickness is defined as the thickness of the low-isoechoic area on the free wall of the right ventricle in the parasternal long-axis and short-axis views. Recent studies have suggested that it might support current risk stratification strategies in identifying an increased risk of metabolic syndrome.Objectives. The aim of this study is to explore a new measurement site which can better reflect EAT thickness and to assess its value in predicting metabolic syndrome. Material and methods.A total of 975 Chinese adults were measured for EAT thickness on the right ventricular anterior free wall (EAT-rv) and on the anterior interventricular groove (EAT-ivg) with echocardiography. The correlation between EAT thickness and metabolic syndrome was analyzed, as was the agreement between epicardial adipose volume (EAV) and EAT thickness. Independent risk factors of EAT thickness were identified and the predictive value of EAT thickness was assessed.Results. Epicardial adipose tissue thickness was higher in older participants and those with obesity, diabetes, hypertension, hypertriglyceridemia, and metabolic syndrome, and it was lower in male participants. The EAT-ivg was higher in the participants with hypo-high-density-lipoprotein cholesterolemia than in those without the disorder, but the EAT-rv values were not statistically different. The kappa value was 0.524 between EAT-rv and EAV, and 0.783 between EAT-ivg and EAV. Advanced age, large waist circumference and female gender were independent risk factors of high EAT-ivg, while high-density-lipoprotein (HDL) cholesterol was a protective factor. The EAT-ivg was associated with metabolic syndrome. The area under the curve of EAT-ivg applied in predicting metabolic syndrome was greater than that of EAT-rv (0.715 vs 0.648). Conclusions.The EAT-ivg was more consistent with EAV than EAT-rv, was independently associated with metabolic syndrome and had a higher value in predicting metabolic syndrome than EAT-rv. Therefore, the anterior interventricular groove can serve as a new measurement site which better reflects EAT thickness.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 44%

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A new measurement site for echocardiographic epicardial adipose tissue thickness and its value in predicting metabolic syndrome

et al. 2019

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“…In physiologic conditions, epicardial fat protects the heart from mechanical stress and may release anti-inflammatory cytokines, endothelium protective and anti-oxidant substances [21,22]. However, in metabolic diseases, such as obesity, metabolic syndrome or diabetes mellitus, epicardial adipose tissue increases and becomes dysfunctional producing pro-inflammatory and proatherogenic molecules [23,24,25,26].…”

Section: Resultsmentioning

confidence: 99%

Serum Gamma-Glutamyl Transferase Is Associated with Epicardial Fat Thickness in Middle Aged Women

Albu¹,

Moldovan²,

Petra³

et al. 2020

Rev. Chim.

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Accumulating data indicate that gamma-glutamyl transferase (GGT) is associated with cardiovascular morbidity and mortality. A positive correlation between GGT levels and various cardiometabolic risk factors has been previously found. The aim of this study was to investigate the relationship between GGT and epicardial fat tissue thickness (EFTT) a marker of visceral adiposity. A total of one hundred five middle-aged (40-60 years) women were included in this cross-sectional study. EFTT was measured using 2-dimensional echocardiography, on the free wall of the right ventricle perpendicularly to the aortic annulus. Biochemical parameters were determined with an automated biochemical analyzer. Values of GGT were logarithmically transformed (log-GGT) because of their skewed distribution. We found that log-GGT correlated with age, body mass index, abdominal circumference, EFTT, triglycerides, fasting plasma glucose and uric acid. In multivariate regression analysis, log-GGT levels were independently associated with EFTT (�=0.27, p=0.004), postmenopausal status (�=0.25, p=0.008) and triglycerides (�=0.23, p=0.01). In conclusion, in middle-aged women, GGT independently correlated with EFTT and may be a marker of visceral adiposity and increased cardiovascular risk.

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“…Moreover, the increase in visceral adiposity and the resistance to insulin action lead to an increase in oxidative stress and generate a low-grade inflammatory process that will result in an increase in metabolic changes leading to non-cardiovascular diseases also. [3][4][5] Thus, a study was planned to observe the relationship among lipid profile and BMI in patients coming to our hospital in NCR region of India.…”

Section: Introductionmentioning

confidence: 99%

CORRELATION OF LIPID PROFILE & BODY MASS INDEX (BMI) OF PATIENTS AT A TERTIARY CARE HOSPITAL: A CROSS SECTIONAL STUDY

Taliyan

Yadav

Gupta

2019

IJMBS

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Background: Sedentary daily life have an impact on the prevalence and incidence of metabolic syndrome disorder and results in development of type 2 diabetes mellitus, Dyslipidemia and metabolic disorders that aggravate the risk in the development of cardiovascular diseases (CVD). Methods: In our study Data of 92 males and 112 females, from the age group of 25 to 55 years were selected from December 2018 to July 2019 in a cross sectional manner. Blood sample (3 ml) was collected from each subject. Serum was separated by centrifuging blood at 3000 rpm for 10 min and analyzed for lipid profile by Siemens Dimension RXL max, wet chemistry analyzer. Body mass index (BMI) was calculated as weight in kilograms divided by the square of height in meters. Results: In our hospital based study we estimated the lipid profile in individuals categorized into two groups. (Group 1 BMI <25) and (Group 2 BMI ≥25), we found the values of Triglycerides, LDL and VLDL in Group 1 are lower as compared to Group 2 values for same analytes. Conclusion: Our study found positive correlation between lipid profile and obesity. Results of this cross sectional study again prove that, Obesity predisposes individuals to metabolic syndrome associated ailments. Keywords: BMI, Lipid Profile, Metabolic Syndrome, Obesity, Dyslipidemia

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Epicardial Adipose Tissue in the General Middle-aged Population and Its Association With Metabolic Syndrome

Cited by 23 publications

References 37 publications

A new measurement site for echocardiographic epicardial adipose tissue thickness and its value in predicting metabolic syndrome

A new measurement site for echocardiographic epicardial adipose tissue thickness and its value in predicting metabolic syndrome

Serum Gamma-Glutamyl Transferase Is Associated with Epicardial Fat Thickness in Middle Aged Women

CORRELATION OF LIPID PROFILE & BODY MASS INDEX (BMI) OF PATIENTS AT A TERTIARY CARE HOSPITAL: A CROSS SECTIONAL STUDY

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