Epicardial adipose tissue is related to coronary collateral vessel formation in patients with acute coronary syndrome

Şen, Fatih; Yılmaz, Samet; Şen, Ömer; Balc, Kevser Gülcihan; Duman, I.; Topaloğlu, Serkan; Temizhan, Ahmet; Aras, Dursun

doi:10.3109/14017431.2015.1023345

Cited by 3 publications

(1 citation statement)

References 28 publications

(17 reference statements)

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“…Furthermore, thick EAT was correlated with the presence of coronary collateral vessels (CCVs) in patients presenting with ACS. It suggests that EAT plays a role in the development of CCVs, which may contribute to alleviating ACS outcomes [180]. Excess echocardiographic EAT thickness was an independent predictor of no-reflow phenomenon in STEMI patients who underwent PCI [179,181], and coronary slow flow phenomenon, which appears as a slowed stream of contrast without visible stenosis in coronary angiography.…”

Section: Eat Thicknessmentioning

confidence: 92%

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

Krauz,

Kempiński,

Jańczak

et al. 2024

IJMS

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Epicardial adipose tissue (EAT) is a fat deposit surrounding the heart and located under the visceral layer of the pericardium. Due to its unique features, the contribution of EAT to the pathogenesis of cardiovascular and metabolic disorders is extensively studied. Especially, EAT can be associated with the onset and development of coronary artery disease, myocardial infarction and post-infarct heart failure which all are significant problems for public health. In this article, we focus on the mechanisms of how EAT impacts acute coronary syndromes. Particular emphasis was placed on the role of inflammation and adipokines secreted by EAT. Moreover, we present how EAT affects the remodeling of the heart following myocardial infarction. We further review the role of EAT as a source of stem cells for cardiac regeneration. In addition, we describe the imaging assessment of EAT, its prognostic value, and its correlation with the clinical characteristics of patients.

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Section: Eat Thicknessmentioning

confidence: 92%

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

Krauz,

Kempiński,

Jańczak

et al. 2024

IJMS

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Relation of Quantity of Subepicardial Adipose Tissue to Infarct Size in Patients With ST-Elevation Myocardial Infarction

Bière

Behaghel

Mateus

et al. 2017

The American Journal of Cardiology

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Is echocardiographic epicardial fat thickness increased in patients with coronary artery disease? A systematic review and meta-analysis

et al. 2018

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BackgroundThe relation of epicardial fat thickness (EFT) to coronary artery disease (CAD) has recently been reported in multiple studies. Echocardiography is a safe and relatively inexpensive and accessible approach to assess regional EFT, which can be performed easily in many centers.ObjectiveTo determine the association between echocardiographic EFT and the presence or the absence of CAD.MethodsThis was a systematic review and meta-analysis conducted on literature available in electronic databases up to March 2018. The articles measuring EFT by echocardiography in the right ventricular (RV) free wall were included in the study. The quality of the enrolled items was assessed using the Methodological Index for Non-Randomized Studies (MINORS) checklist. The analyses were performed using the Comprehensive Meta-Analysis version 2 software. Cochran’s Q test and I2 index were used to evaluate heterogeneity.ResultsThis meta-analysis was performed on 13 studies involving 2,436 patients (1,622 with CAD, and 814 without CAD). The maximum EFT reported by echocardiography was 12.9±2.7 mm in the CAD group and 8.4±2.5 mm in the non-CAD group. The minimum EFT reported by echocardiography was 2.2±1.8 mm in the CAD group and 1.8±1.4 mm in the non-CAD group. The heterogeneity was found among the researched studies (I2=91.8%, p=0.000, Q-value=146.43, df [Q] =12) using the random effect model. The patients with CAD had a significantly higher echocardiographic EFT than those without CAD (SMD=1.03, 95% CI= 0.70–1.37, p=0.000).ConclusionAccording to the findings of this meta-analysis, the echocardiographic EFT in the subjects with CAD was significantly higher than that of those without CAD. The measurement of echocardiographic EFT seems to be an acceptable strategy for risk stratification of heart diseases considering ease of use, cost-effectiveness and non-exposure characteristics, compared to other imaging interventions.

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Epicardial adipose tissue is related to coronary collateral vessel formation in patients with acute coronary syndrome

Abstract: EAT thickness on admission was associated with the presence of CCVs in patients with ACS.

Cited by 3 publications

References 28 publications

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

Relation of Quantity of Subepicardial Adipose Tissue to Infarct Size in Patients With ST-Elevation Myocardial Infarction

Is echocardiographic epicardial fat thickness increased in patients with coronary artery disease? A systematic review and meta-analysis

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