Epicardial adipose tissue thickness in systemic sclerosis patients without overt cardiac disease

Karadağ, Duygu Temiz; Şahı̇n, Tayfun; Tekeoğlu, Senem; Işık, Ö. Özdemir; Yazıcı, Ayten; Çefle, Ayşe

doi:10.1007/s00296-019-04306-8

Cited by 5 publications

(6 citation statements)

References 37 publications

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“…Furthermore, evidence from the current review highlights a clear correlation between increased EFT and elevated levels of BNP/NT-proBNP in individuals with an increased risk of heart failure, particularly in the presence of illnesses such as CAD. Similar observations were identified in patients with systemic sclerosis [ 39 ], a condition consistent with overt CVD-related complications such as fibrosis, myocarditis, pulmonary hypertension and blood vessel abnormalities [ 49 – 51 ]. Interestingly, patients with AIS also displayed increased EFT, which was positively correlated with NT-proBNP levels [ 40 ].…”

Section: Discussionsupporting

confidence: 75%

“…In NICMP patients, EFT correlated inversely with BNP and predicts impaired cardiomyocyte function indicating the severity of heart failure in NICMP Satisfactory Controls 38 51.1 ± 10.0 6.1 20000 [ 38 ] Case–control Acute Ischemic Stroke (AIS) 61 71.4 ± 11 4.8 1 327 69 (48%) Turkey EFT is increased in AIS patients and correlates positively with NT-proBNP concentrations and aortic stiffness. EFT and NT-proBNP levels can provide information on arterial function in patients with AIS Satisfactory Controls 82 68.6 ± 8 3.8 203 [ 39 ] Case–control Systemic Sclerosis (SSc) 47 52.1 ± 12.4 6 111# 8 (10%) Turkey EFT was significantly increased in patients with SSc compared to the control group. Elevated BNP levels indicated a link between BNP and EFT in SSc patients without overt cardiovascular disease Good Controls 36 49.4 ± 8.4 5 70 Age is indicated as mean ± SD or *median and interquartile range.…”

Section: Resultsmentioning

confidence: 99%

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A systematic review exploring the significance of measuring epicardial fat thickness in correlation to B-type natriuretic peptide levels as prognostic and diagnostic markers in patients with or at risk of heart failure

et al. 2021

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Emerging evidence suggests that epicardial fat thickness (EFT) may be a critical feature to understand cardiac health and determine the risk of heart failure. The current review critically assesses and discusses evidence on the efficiency of measuring EFT, in comparison to the well-known markers B-type natriuretic peptide (BNP) and its N-terminal fragment pro-B-type natriuretic peptide (NT-proBNP), as a prognostic and diagnostic approach in individuals with or at risk of heart failure. A systematic approach was undertaken to search major databases, PubMed, Scopus, Google Scholar and the Cochrane library to identify studies that quantified EFT and serum BNP/NT-proBNP levels in individuals with or at risk of heart failure. Twelve studies met the inclusion criteria and a total of 1983 participants were included in this systematic review. Evidence shows a clear association between increased EFT and elevated BNP/NT-proBNP levels in individuals with metabolic disease and suggests that both methods can be used for heart failure diagnosis and prognosis. However, due to the broad spectrum of challenges linked with measuring EFT, BNP/Pro-BNP is the predominant method used for heart failure diagnosis and prognosis in clinical practice. Nonetheless, measuring EFT provides a powerful and reproducible diagnostic tool for risk stratification and heart failure diagnosis and prognosis. Importantly, measuring EFT proves valuable to validate BNP/NT-proBNP levels to predict heart failure, especially due to its non-invasive nature.

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Section: Discussionsupporting

confidence: 75%

Section: Resultsmentioning

confidence: 99%

A systematic review exploring the significance of measuring epicardial fat thickness in correlation to B-type natriuretic peptide levels as prognostic and diagnostic markers in patients with or at risk of heart failure

et al. 2021

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“…Increased EAD thickness is associated with endothelial dysfunction in spondyloarthritis (28). It suggests that EAD thickness is a candidate for atherosclerotic risk assessment in patients with systemic sclerosis without open heart disease (29). A systematic review and meta-analysis also shows that familial Meditterian fever patients have a higher risk of developing EAD than controls (30).…”

Section: Discussionmentioning

confidence: 98%

Evaluation of Epicardial Fat Thickness, a New Indicator of the Cardiovascular Risk Factor, in Patients With Systemic Lupus Erythematosus

Hakbilen,

Yılmaz,

Özer

et al. 2023

qrheumatol

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Aim: Aim: Systemic lupus erythematosus (SLE) is a chronic autoimmune rheumatic disease with high cardiovascular mortality. Epicardial adipose tissue (EAD) is the visceral fat located between the myocardium and pericardium. EAD is recognized as an active metabolic and inflammatory tissue capable of producing and releasing various preatherosclerotic and proinflammatory hormones, cytokines. EAD is associated with coronary artery disease, metabolic syndrome, and subclinical atherosclerosis. In this study, we investigated the relationship between EAD and SLE patients. Material and Methods:Material and Methods: A total of 73 patients were recruited from the rheumatology department of a single center as a case-control study. The participants were divided into two groups: 73 patients with SLE (group 1) and 60 age-and sex-matched controls (group 2). Laboratory and radiological results were obtained from the electronic registration database. Data were analyzed and compared between the groups.Results: Results: There was no significant difference between the groups in terms of age, gender, height, weight, or body mass index (BMI). EAD was found to be significantly higher in SLE patients than in the control group. In the SLE group, EAD was found to be significantly higher in patients with low complement levels than in those without. There was a positive correlation between EAD and age, leukocytes, neutrophils, C-reactive protein (CRP), and BMI, but a negative correlation was found between SLE disease activity index. Conclusion: Conclusion:Increased EAD was found in SLE patients compared with the control group. In addition, a correlation was found between increased EAD and low complement and CRP. EAD may be a measurable and modifiable potential therapeutic target associated with inflammation and cardiovascular risk in patients with SLE.

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“…There are a few studies in the literature that have evaluated EATT in other rheumatic diseases in which increased EATT values have been demonstrated in patients with systemic sclerosis, systemic lupus erythematosus (SLE), ankylosing spondylitis, and inflammatory bowel disease. [ 36 – 39 ]…”

Section: Discussionmentioning

confidence: 99%

Increased epicardial adipose tissue thickness as a sign of subclinical atherosclerosis in patients with rheumatoid arthritis and ıts relationship with disease activity ındices

Keleşoğlu Dinçer,

Şahan

2024

Intern Emerg Med

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Epicardial adipose tissue is a novel cardiometabolic risk factor and indicator of subclinical atherosclerosis. We aimed to evaluate the epicardial adipose tissue thickness in rheumatoid arthritis (RA) patients and its association with disease activity scores. A total of 81 rheumatoid arthritis patients and 70 age- and sex-matched healthy individuals were recruited for this cross-sectional study. Epicardial adipose tissue thickness (EATT) was measured by transthoracic two-dimensional echocardiography. Tender and swollen joint counts were recorded at the time of inclusion. The laboratory tests included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor, anti-citrullinated protein antibodies, and serum lipid levels. Disease activity was calculated based on Disease Activity Scores for 28 joints (DAS-28) ESR and CRP, the Simple Disease Activity Index (SDAI), and the Clinical Disease Activity Index (CDAI). Epicardial adipose tissue thickness was significantly higher in the RA patients compared to the healthy controls (p < 0.001). We found statistically significant correlations of EATT with all disease activity indices (p < 0.001) and CRP (p = 0.002). According to a cut-off value of 6.4 mm determined for epicardial adipose tissue thickness, the RA patients with thickness ≥ 6.4 mm had higher disease activity scores and CRP levels. In the multivariable regression analysis, only SDAI score was found as an independent risk factor for increased EATT (OR, (95%CI), 13.70 (3.88–48.43), p < 0.001). Epicardial adipose tissue thickness measurement by echocardiography is a reliable method for assessing subclinical atherosclerosis in rheumatoid arthritis patients, and a higher disease activity score is an independent risk factor for coronary artery disease.

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Epicardial adipose tissue thickness in systemic sclerosis patients without overt cardiac disease

Cited by 5 publications

References 37 publications

A systematic review exploring the significance of measuring epicardial fat thickness in correlation to B-type natriuretic peptide levels as prognostic and diagnostic markers in patients with or at risk of heart failure

A systematic review exploring the significance of measuring epicardial fat thickness in correlation to B-type natriuretic peptide levels as prognostic and diagnostic markers in patients with or at risk of heart failure

Evaluation of Epicardial Fat Thickness, a New Indicator of the Cardiovascular Risk Factor, in Patients With Systemic Lupus Erythematosus

Increased epicardial adipose tissue thickness as a sign of subclinical atherosclerosis in patients with rheumatoid arthritis and ıts relationship with disease activity ındices

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