Epicardial Adipose Tissue Thickness in Hemodialysis Patients

Taşolar, Hakan; Eren, Necmi; Binnetoğlu, Emine; Altun, Burak; Temız, Ahmet; Gazı, Emıne; Barutçu, Ahmet; Altunören, Orçun; Çölkesen, Yücel; Uysal, Fatma

doi:10.1111/echo.12498

Cited by 21 publications

(14 citation statements)

References 31 publications

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“…Bettencourt et al [ 41 ] showed that EFT is directly related to gender, age, BMI, waist circumference, abdominal visceral fat tissue, and atherosclerotic load. EFT is associated with BMI in females with DM [ 11 ] and was higher in females with a BMI >27 kg m -2 [ 16 ]. Moreover, EFT is an independent predictor of intra-abdominal visceral fat tissue [ 42 – 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…Epicardial fat thickness (EFT) is associated with the thickness of visceral fat tissue [ 9 ]. In addition to being an anatomical barrier, epicardial fat tissue is also a local reserve for proinflammatory cytokines [ 10 ] and is related to obesity, hypertension, insulin resistance and coronary artery disease [ 11 – 16 ]. Currently, EFT measurement is performed via transthoracic echocardiography (TTE), magnetic resonance imaging (MRI) and multi-slice computed tomography (CT) [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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The relationship between epicardial fat thickness and gestational diabetes mellitus

Nar

İnci

Aksan

et al. 2014

Diabetol Metab Syndr

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AimGestational diabetes mellitus (GDM) is associated with cardiovascular diseases; however, the relationship between epicardial fat thickness (EFT) and GDM remains unclear. The present study evaluates and compares EFT using transthoracic echocardiography in pregnant women with GDM.Materials and methodsThis cross-sectional study included 129 pregnant women in the third trimester: 65 with GDM (GDM group) and 64 with uncomplicated pregnancies (control group). As defined by the World Health Organization, the diagnosis of GDM was based on an abnormal 2-h oral glucose tolerance test (OGTT) results. We used echocardiography to measure EFT in blood samples for all the participants.ResultsThe postprandial blood glucose level was significantly higher in the GDM group than in the control group (P < 0.001). There were no significant differences in BMI, heart rate, systolic and diastolic blood pressure or lipid parameters between the groups. In the GDM group, isovolumic relaxation time (IVRT) parameters were significantly higher than in the control group. EFT was significantly higher in the GDM group (P < 0.001) and was correlated with postprandial glucose, BMI, age, and heart rate in both the groups. Only postprandial glucose and BMI remained significantly associated with EFT after multiple stepwise regression analysis.ConclusionEchocardiographically measured EFT was significantly higher in the patients with GDM. The findings show that EFT was strongly correlated with postprandial glucose.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The relationship between epicardial fat thickness and gestational diabetes mellitus

Nar

İnci

Aksan

et al. 2014

Diabetol Metab Syndr

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“…While EATT is positively correlated with CIMT in several diseases (Iacobellis and Willens 2009 ; Altun et al 2014 ; Natale et al 2009 ; Kim et al 2013 ), to our knowledge no data are available on the potential role of EATT in predicting early atherosclerosis as well as CIMT in patients with ADPKD. Therefore, our study was designed to evaluate the relationship between echocardiographic EATT and CIMT, as predictors of early atherosclerosis, in normotensive ADPKD patients.…”

Section: Introductionmentioning

confidence: 96%

“…CIMT is a well-known independent predictor of cardiovascular diseases and recognized as a novel marker of subclinical atherosclerosis (Polak et al 2011 ). In addition, on the basis of its strong correlation with obesity, insulin resistance, metabolic syndrome, hypertension, diabetes, and subclinical atherosclerosis (Polak et al 2011 ; Iacobellis and Willens 2009 ); echocardiographic measurement of epicardial adipose tissue thickness (EATT) has also been indicated to be a potential marker of atherosclerosis and of CIMT and thus might be used as a simple tool for predicting cardiometabolic risk (Polak et al 2011 ; Iacobellis and Willens 2009 ; Altun et al 2014 ; Chaowalit et al 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness

et al. 2016

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Epicardial adipose tissue thickness (EATT) is suggested as a novel marker of subclinical atherosclerosis. Despite increased carotid intima-media thickness (CIMT) in autosomal dominant polycystic kidney disease (ADPKD) patients, the extent of the relationship between CIMT and EATT is unknown. The main purpose of our study was to evaluate the relation between EATT and CIMT in normotensive ADPKD patients with well-preserved renal function. Fifty-five normotensive ADPKD patients with normal renal function and 50 healthy control subjects were included in the study. EATT and CIMT were measured by echocardiography in all subjects. Correlation between EATT and CIMT was evaluated in ADPKD patients, while multivariate linear regression analysis was performed to determine factors predicting EATT and CIMT. ADPKD patients had significantly higher levels CIMT [0.7 (0.4–1.2) vs. 0.5 (0.4–0.8) mm, p < 0.001] and EATT (6.8 ± 2.7 vs. 4.8 ± 1.2 mm, p < 0.001) as compared with control subjects. Significant positive correlation was found between EATT and CIMT (r = 0.58, p < 0.001). Higher CRP levels (OR 54.7, 95 % CI 37.44–72.01, p < 0.001) and having ADPKD (OR 10.2, 95 % CI 2.53–17.86, p = 0.01) were the only independent factors associated with a higher EATT. A higher age (OR 0.35, 95 % CI −0.02 to 0.71, p = 0.06) tended to be independently associated with a higher EATT. In conclusion, our findings suggest that EATT, being simply measured by echocardiography and correlated with CIMT, can be used to detect subclinical atherosclerosis in normotensive ADPKD patients.

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“…Again, a study including 62 hemodialysis patients identified a strong relationship between CIMT and EFT thickness. 35 Nakanishi et al 36 used computed tomography to measure EFT levels and reported that patients with high levels had more coronary artery calcification. In studies by Cece et al 12 and Resorlu et al, 37 CIMT values in AS patients were found to be higher than those of the control group.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Atrial Conduction Times, Epicardial Fat Thickness and Carotid Intima-Media Thickness in Patients With Ankylosing Spondylitis

et al. 2016

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Objectives: This study aims to determine the relationship between atrial electromechanical delay (EMD), carotid intima-media thickness (CIMT), and epicardial fat thickness (EFT) in ankylosing spondylitis (AS), which has a complicated inflammatory nature. Patients and methods:The study population included 42 consecutive patients with AS (28 males, 14 females; mean age 39.3±8.5 years; range 22 to 60 years) and 40 healthy subjects as controls (24 males, 16 females; mean age 37.2±8.7 years; range 22 to 60 years) (p>0.05). All patients underwent a standard tissue Doppler echocardiography to assess the left ventricular diastolic dysfunction, atrial EMD, CIMT, and EFT. All values were compared between the groups. Results: Interatrial (29.5±5.8 ms vs. 17.9±5.3 ms) left and right intraatrial EMD (18.2±4.6 ms and 11.7±3.5 ms vs. 11.9±3.2 ms and 7.1±3.2 ms, respectively) intervals were longer in AS patients than in healthy controls (all p<0.001). Left and right CIMT (0.50±0.11 mm and 0.44±0.06 mm vs. 0.51±0.11 mm and 0.43±0.04 mm, respectively) and EFT (0.73±0.15 cm and 0.63±0.07 cm) values were higher in AS patients than in healthy controls (all p<0.01). Conclusion: To our best knowledge, this is the first report evaluating the atrial EMD, CIMT, and EFT values together in AS patients. As indicators of cardiovascular involvement, all parameters were higher in AS patients.

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Epicardial Adipose Tissue Thickness in Hemodialysis Patients

Abstract: Epicardial adipose tissue thickness may be a useful indicator of early atherosclerosis in HD patients.

Cited by 21 publications

References 31 publications

The relationship between epicardial fat thickness and gestational diabetes mellitus

The relationship between epicardial fat thickness and gestational diabetes mellitus

Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness

Evaluation of Atrial Conduction Times, Epicardial Fat Thickness and Carotid Intima-Media Thickness in Patients With Ankylosing Spondylitis

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