Epicardial adipose tissue volume and cardiovascular disease in hemodialysis patients

Turan, Mehmet; Güngör, Özkan; Aşçı, Gülay; Kırçelli, Fatih; Acar, Türker; Yaprak, Mustafa; Ceylan, Naim; Demirci, Meltem Seziş; Bayraktaroğlu, Selen; Töz, Hüseyin; Özkahya, Mehmet; Ok, Ercan

doi:10.1016/j.atherosclerosis.2012.10.061

Cited by 32 publications

(33 citation statements)

References 20 publications

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“…Although the relationship between regular fatty liver disease and EFT is known [3], it was not mentioned by the authors. Furthermore, in kidney disease patients, EFT has been positively associated with atherosclerosis, arterial stiffness (AS) and the presence of coronary artery calcification [4]. We feel it would have been useful if the authors had mentioned these factors, including liver and kidney function tests.…”

mentioning

confidence: 99%

Epicardial Fat Thickness and Cardio-Ankle Vascular Index without Other Inflammatory Markers May Not Provide Information to Clinicians about the Systemic Inflammation

Balta¹,

Demırkol²,

Küçük³

et al. 2013

Cardiology

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mentioning

confidence: 99%

Epicardial Fat Thickness and Cardio-Ankle Vascular Index without Other Inflammatory Markers May Not Provide Information to Clinicians about the Systemic Inflammation

Balta¹,

Demırkol²,

Küçük³

et al. 2013

Cardiology

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“…On the other hand, in kidney disease patients, EFT was positively correlated with atherosclerosis, arterial stiffness and the presence of coronary artery calcification. 4 We think that the results of the study would be stronger, if the authors had mentioned these factors including liver and kidney function tests.…”

Section: Dear Editormentioning

confidence: 95%

Epicardial Fat Thickness Should Be Evaluated with Other Inflammatory Markers and Cardiovascular Risk Factors

et al. 2013

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“…Turan et al showed that an increased EAT volume in patients who were treated with hemodialysis for a long time was associated with carotid atherosclerosis, arterial stiffness and coronary calcification. They suggested that the measurement of EAT in these patients can be used as a predictor of vascular injury 8) . Endothelial dysfunction is an independent predictor of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Turkmen et al reported higher EAT in dialysis patients compared to healthy controls, and a significant association of EAT with malnutrition-inflammation-atherosclerosis-calcification (MIAC) syndrome 7) . Additionally, it was shown that EAT was correlated with atherosclerosis, arterial stiffness and the presence of coronary calcification in long-term hemodialysis (HD) patients 8) .…”

Section: Biochemical Measurementsmentioning

confidence: 99%

A Low Serum Free Triiodothyronine Level is Associated with Epicardial Adipose Tissue in Peritoneal Dialysis Patients

Koçyiğit

Güngör

Ünal

et al. 2014

J Atheroscler Thromb

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Aim: Cardiovascular disease is a major cause of mortality in dialysis patients. Epicardial adipose tissue (EAT) has been proposed as a cardiovascular risk marker in this population. Subclinical hypothyroidism and low free triiodothyronine (fT3) levels are associated with EAT in patients without chronic renal failure. The aim of this study was to investigate the relationship between EAT and low free T3 levels in peritoneal dialysis (PD) patients. Methods: A total of 125 prevalent PD patients were enrolled in this cross-sectional study. The epicardial fat thickness (EFT) was measured by echocardiography, and the endothelial function was assessed by flow mediated dilatation (FMD). Thyroid function tests were performed by an enzyme immunoassay. Results: The mean age of the patients was 51±13, and the time on PD was 36 months. The mean EFT was 6.7±2.9 mm. The EFT correlated positively with the patient age, systolic blood pressure (BP), mean BP, high sensitivity C-reactive protein (hs-CRP) level and body mass index (BMI), and negatively with the fT3 level and FMD. The median fT3 value was 2.53, and patients were divided according to their serum fT3 values (within the normal range and below the reference level). Compared with patients in the low fT3 group, the subjects in the normal fT3 group had higher serum albumin levels and FMD, but a lower BMI, plasma fasting glucose level, EFT, TSH level, hs-CRP level, low density lipoprotein (LDL) cholesterol level and mean BP in office measurements, and both the diastolic BP and mean BP by ambulatory blood pressure measurement. A multivariate linear regression analysis showed that the EFT was predicted by the hs-CRP and fT3 levels. Conclusion: Low free T3 levels are associated with the epicardial fat thickness in PD patients. Further studies are needed to evaluate the pathogenesis and to support these findings.

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Epicardial adipose tissue volume and cardiovascular disease in hemodialysis patients

Cited by 32 publications

References 20 publications

Epicardial Fat Thickness and Cardio-Ankle Vascular Index without Other Inflammatory Markers May Not Provide Information to Clinicians about the Systemic Inflammation

Epicardial Fat Thickness and Cardio-Ankle Vascular Index without Other Inflammatory Markers May Not Provide Information to Clinicians about the Systemic Inflammation

Epicardial Fat Thickness Should Be Evaluated with Other Inflammatory Markers and Cardiovascular Risk Factors

A Low Serum Free Triiodothyronine Level is Associated with Epicardial Adipose Tissue in Peritoneal Dialysis Patients

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