Epicardial and periaortic fat characteristics in ischemic stroke: Relationship with stroke etiology and calcification burden

Rodríguez-Granillo, Gastón A.; Cirio, Juan; Ciardi, Celina; Caballero, M.L.; Fontana, Lucía; Pérez, Nicolás; Ingino, Carlos A.; Lylyk, Pedro

doi:10.1016/j.ejrad.2021.110102

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Increased PAT volume has been demonstrated in patients with COPD and patients undergoing peritoneal dialysis (24,25). In addition, in a study evaluating PAT volume in ischemic stroke, higher periaortic fat attenuation was observed while there was no change in PAT volume in cardioembolic strokes (26). In peripheral arterial disease, PAT was demonstrated to be an independent risk factor in the Framingham heart study, and in this study, increased PAT volume was associated with lower ankle brachial index and claudication (11).…”

Section: Discussionmentioning

confidence: 97%

Periaortic adipose tissue index: A new approach to the relationship between coronary stenosis severity/lesion complexity and periaortic adipose tissue

AKBAY¹,

Akıncı²,

Uysal³

et al. 2022

J. Exp. Clin. Med.

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Periaortic adipose tissue (PAT) is associated with atherosclerosis. The severity of coronary stenosis with PAT has not been evaluated with conventional coronary angiography (CAG). The aim of the study is to determine the relationship between PAT and coronary stenosis severity/ complexity, and to evaluate it with the periaortic adipose tissue index (PATI), a new index derived from PAT. Patients who underwent CAG and thoracic computed tomography (CT) between January 2017 and January 2022 were included in the study. PAT volume was calculated by evaluating CT images, and PATI was calculated by dividing the PAT volume by the circumference of the descending aorta. Patients were divided into two groups according to the presence of ≥50% stenosis on CAG. The correlation of PAT and PATI with the SYNTAX score was evaluated. In our study, 263 patients [mean age 64.5(54/72), male 164 (62.4%)] were evaluated. Severe coronary artery disease (CAD) was observed in 181 patients (68.8%). PAT volume and PATI were significantly higher in patients with severe stenosis (p<0.001, for both). When PAT and PATI were evaluated alongside CAD risk factors, an independent association between PATI and severe CAD was discovered (β:0.581, p:0.97, β:0.968, p:0.006, respectively). No correlation was found between SYNTAX score and PAT and PATI (r:-0.026, p:0.73, r:-0.019, p:0.19, respectively). In our study, PAT and PATI were higher in patients with severe coronary stenosis, and there was an independent relationship between PATI and severe stenosis. We found no relationship between PAT and PATI and the SYNTAX score.

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Section: Discussionmentioning

confidence: 97%

Periaortic adipose tissue index: A new approach to the relationship between coronary stenosis severity/lesion complexity and periaortic adipose tissue

AKBAY¹,

Akıncı²,

Uysal³

et al. 2022

J. Exp. Clin. Med.

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“…Rodríguez-Granillo and collaborators examined the density of periaortic adipose tissue on CT in patients suffering from cardioembolic, non-cardioembolic, and unclear genesis strokes showing that the aortic PVAT is greater in patients with cardioembolic stroke [23].…”

Section: Perivascular Adipose Tissue Attenuation On Aortamentioning

confidence: 99%

Cardiovascular Disease from Pathophysiology to Risk Estimation: Is Inflammation Estimated through Perivascular Attenuation on Computed Tomography the Key?

Tuttolomondo,

Niccoli,

Martini

et al. 2024

Life

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(1) Background: Systemic inflammation stands as a well-established risk factor for ischemic cardiovascular disease, as well as a contributing factor in the development of cardiac arrhythmias, notably atrial fibrillation. Furthermore, scientific studies have brought to light the pivotal role of localized vascular inflammation in the initiation, progression, and destabilization of coronary atherosclerotic disease. (2) Methods: We comprehensively review recent, yet robust, scientific evidence elucidating the use of perivascular adipose tissue attenuation measurement on computed tomography applied to key anatomical sites. Specifically, the investigation extends to the internal carotid artery, aorta, left atrium, and coronary arteries. (3) Conclusions: The examination of perivascular adipose tissue attenuation emerges as a non-invasive and indirect means of estimating localized perivascular inflammation. This measure is quantified in Hounsfield units, indicative of the inflammatory response elicited by dense adipose tissue near the vessel or the atrium. Particularly noteworthy is its potential utility in assessing inflammatory processes within the coronary arteries, evaluating coronary microvascular dysfunction, appraising conditions within the aorta and carotid arteries, and discerning inflammatory states within the atria, especially in patients with atrial fibrillation. The widespread applicability of perivascular adipose tissue attenuation measurement underscores its significance as a diagnostic tool with considerable potential for enhancing our understanding and management of cardiovascular diseases.

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Epicardial and periaortic fat characteristics in ischemic stroke: Relationship with stroke etiology and calcification burden

Cited by 2 publications

References 30 publications

Periaortic adipose tissue index: A new approach to the relationship between coronary stenosis severity/lesion complexity and periaortic adipose tissue

Periaortic adipose tissue index: A new approach to the relationship between coronary stenosis severity/lesion complexity and periaortic adipose tissue

Cardiovascular Disease from Pathophysiology to Risk Estimation: Is Inflammation Estimated through Perivascular Attenuation on Computed Tomography the Key?

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