Epicardial and pericoronary adipose tissue and coronary plaque burden in patients with Cushing’s syndrome: a propensity score-matched study

Wang, M.; Qin, L.; Bao, W.; Xu, Z.; Han, L.; Yan, F.; Yang, W.

doi:10.1007/s40618-023-02295-x

J Endocrinol Invest

2024

DOI: 10.1007/s40618-023-02295-x

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Epicardial and pericoronary adipose tissue and coronary plaque burden in patients with Cushing’s syndrome: a propensity score-matched study

M. Wang,

L. Qin,

W. Bao

et al.

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2024

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Cited by 4 publications

References 40 publications

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Assessment of aortic perivascular and renal sinus fat in endogenous cortisol excess of different etiology

Bilger,

Cerit,

Babayeva

et al. 2024

Hormones

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Assessment of aortic perivascular and renal sinus fat in endogenous cortisol excess of different etiology

Bilger,

Cerit,

Babayeva

et al. 2024

Hormones

View full text Add to dashboard Cite

Epicardial adipose tissue volume highly correlates with left ventricular diastolic dysfunction in endogenous Cushing’s syndrome

Ran,

Su,

et al. 2024

Annals of Medicine

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Background Cushing’s syndrome (CS) is associated with increased risk for heart failure, which often initially manifests as left ventricular diastolic dysfunction (LVDD). In this study, we aimed to explore the potential risk factors of LVDD in CS by incorporating body composition parameters. Methods A retrospective study was conducted on patients diagnosed with endogenous CS no less than 18 years old. The control group consisted of healthy individuals who were matched to CS patients in terms of gender, age, and BMI. LIFEx software (version 7.3) was applied to measure epicardial adipose tissue volume (EATV) on non-contrast chest CT, as well as abdominal adipose tissue and skeletal muscle mass at the first lumbar vertebral level. Echocardiography was used to evaluate left ventricular (LV) diastolic function. Body compositions and clinical data were examined in relation to early LVDD. Results A total of 86 CS patients and 86 healthy controls were enrolled. EATV was significantly higher in CS patients compared to control subjects (150.33 cm 3 [125.67, 189.41] vs 90.55 cm 3 [66.80, 119.84], p < 0.001). CS patients had noticeably increased visceral fat but decreased skeletal muscle in comparison to their healthy counterparts. Higher prevalence of LVDD was found in CS patients based on LV diastolic function evaluated by E/A ratio ( p < 0.001). EATV was proved to be an independent risk factor for LVDD in CS patients (OR = 1.015, 95%CI 1.003–1.026, p = 0.011). If the cut-point of EATV was set as 139.252 cm 3 in CS patients, the diagnostic sensitivity and specificity of LVDD were 84.00% and 55.60%, respectively. Conclusion CS was associated with marked accumulation of EAT and visceral fat, reduced skeletal muscle mass, and increased prevalence of LVDD. EATV was an independent risk factor for LVDD, suggesting the potential role of EAT in the development of LVDD in CS.

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Conventional steroids vs. dual-release hydrocortisone on metabolic, cardiovascular, and bone outcomes in adrenal insufficiency: a 10-year study

Guarnotta,

Di Stefano,

Tomasello

et al. 2024

European Journal of Endocrinology

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Objective Adrenal insufficiency (AI) is characterized by increased mortality compared to general population, mainly due to cardiovascular disease. Conventional glucocorticoid (GC) replacement therapy has a role in determining the increased mortality risk. Primary outcome of the current study was to evaluate the impact of 10 years of conventional GCs and DR-HC on body weight changes in treatment-naive patients with AI. Secondary outcomes were changes from baseline to 5 and 10 years in anthropometric and metabolic profile, insulin sensitivity, cardiovascular, and bone parameters. Design and methods We prospectively randomized 42 patients to conventional GCs (cortisone acetate or hydrocortisone) and 44 to DR-HC (1:1). Anthropometric, metabolic, cardiovascular, and bone parameters were evaluated at baseline and after 5 and 10 years of follow-up. This trial is registered at ClinicalTrials.gov NCT06260462. Results At 10 years of follow-up, patients with conventional GCs had significantly higher values of BMI (P = .031), waist circumference (P = .047), systolic blood pressure (P = .039), total and LDL cholesterol (P = .041 and P = .042), HbA1c (P = .040), HOMA-IR (P = .006), AUC2h of glucose (P < .001), thickness of the interventricular septum in diastole and of the posterior wall (both P < .001) and significantly lower values of oral disposition index (P = .001) and ISI-Matsuda (P < .001), lumbar spine T score (P = .036), and femoral neck Z score (P = .026), compared to patients treated with DR-HC. Conclusions In patients with treatment-naive AI, 10 years of conventional GC treatment is associated with a worsening of metabolic, insulin-sensitivity, cardiac, and bone outcomes, while DR-HC had no impact on them achieving a lower risk of developing comorbidities.

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Epicardial and pericoronary adipose tissue and coronary plaque burden in patients with Cushing’s syndrome: a propensity score-matched study

Cited by 4 publications

References 40 publications

Assessment of aortic perivascular and renal sinus fat in endogenous cortisol excess of different etiology

Assessment of aortic perivascular and renal sinus fat in endogenous cortisol excess of different etiology

Epicardial adipose tissue volume highly correlates with left ventricular diastolic dysfunction in endogenous Cushing’s syndrome

Conventional steroids vs. dual-release hydrocortisone on metabolic, cardiovascular, and bone outcomes in adrenal insufficiency: a 10-year study

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