2018
DOI: 10.1159/000484326
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Epicardial Fat Thickness in Non-Obese Neurologically Impaired Children: Association with Unfavorable Cardiometabolic Risk Profile

Abstract: Background: Cardiovascular risk is reported in disabled children and epicardial fat (EF) is considered an independent predictor of cardiovascular disease (CVD). No data on the EF thickness (EFT) evaluation in disabled children have been published. Objective: We investigated EFT in neurologically impaired (NI) children; its relationship with their metabolic profile was also considered. Methods: Clinical data, body composition estimation, biochemical profile, and ultrasound-measured EFT were performed in 32 disa… Show more

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Cited by 7 publications
(10 citation statements)
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“…Individuals with neurological impairment are at increased risk for frailty and chronic disease due to factors experienced throughout lifespan, such as excessive sedentary behaviors and malnutrition (19). Unfavorable cardio-metabolic profile and high allostatic load have been previously reported in early childhood (911). However, little is known about diabetes in disabled population.…”
Section: Discussionmentioning
confidence: 92%
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“…Individuals with neurological impairment are at increased risk for frailty and chronic disease due to factors experienced throughout lifespan, such as excessive sedentary behaviors and malnutrition (19). Unfavorable cardio-metabolic profile and high allostatic load have been previously reported in early childhood (911). However, little is known about diabetes in disabled population.…”
Section: Discussionmentioning
confidence: 92%
“…As previously reported, IR in these disabled patients was not correlated to BMI nor to energy intake (11). Negative regulation of insulin signaling could be viewed as a physiologic “adaptive mechanism for human survival” that is activated whenever the organism needs to switch from an anabolic to a catabolic or “insulin resistance” state, such as undernutrition, and to mobilize energy to support vital metabolic processes (911, 2426). The restricted physical activity (27) may also play a crucial role on insulin resistance; it causes a rapid loss of lean mass, which is associated with a decline in basal metabolic rate and increased whole body and regional adiposity leading to insulin signaling interference (10).…”
Section: Discussionmentioning
confidence: 99%
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“…Some conditions associated with intellectual or developmental disabilities in children remain highly correlated with cardiovascular risk factors in adulthood (19, 20). In disabled children, predictive cardiovascular signs are reported: hypertension was present in more than 15% of NI children and a epicardial fat measurement, considered an independent predictor of coronary atherosclerotic burden, was thicker than age-matched-controls (21).…”
mentioning
confidence: 99%