(‐)‐Epicatechin gallate, a metabolite of (‐)‐epigallocatechin gallate in grass carp, exhibits antiviral activity in vitro against grass carp reovirus

Zhang, Yitong; Wang, Hao; Su, Meizhen; Lu, Liqun

doi:10.1111/are.14513

Cited by 12 publications

(4 citation statements)

References 21 publications

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“…Additionally, EGCG has been reported to bind to the 67 kDa laminin receptor with a nanomolar Kd value (Tachibana et al., 2004). In our previous study, we found that EGCG could be targeted to the laminin receptor and used to specifically inhibit GCRV infection (Singh et al., 2011; Wang, Liu et al., 2016; Wang, Yu et al., 2016; Zhang et al., 2020). For the first time, we have shown that EGCG can used to control diseases in aquaculture.…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin‐3‐gallate inhibits replication of white spot syndrome virus in the freshwater crayfish Procambarus clarkii

Zhang

Wen

et al. 2021

Journal of Fish Diseases

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The freshwater crayfish Procambarus clarkii is native to North America and Mexico, and it was introduced to China in 1929. The production and consumption of P. clarkii in China are the highest worldwide, reaching 208.96 million tons in 2020. The white spot syndrome virus (WSSV) is a major pathogen that affects shrimp, crayfish, crabs and lobsters, and it has caused widespread loss to the P. clarkii industry. Epigallocatechin‐3‐gallate (EGCG), a small‐molecule compound, has a multitude of biological functions and the ability to bind to the 37 kDa/67 kDa laminin receptor (LamR). EGCG has potential antiviral effects against WSSV. In this study, we evaluated the potential anti‐WSSV applications of EGCG in P. clarkii. We demonstrated that various concentrations (10 μg/g·bw, 20 μg/g·bw and 40 μg/g·bw) of EGCG can suppress WSSV infection in P. clarkii. Histopathological examination revealed no characteristic pathological changes due to EGCG administration in P. clarkii tissues. Furthermore, pharmacokinetics studies of EGCG in P. clarkii revealed its rapid absorption (Tmax = 2 h), and the peak concentrations of EGCG were 73.78 µg/g in the liver and 24.87 µg/g in the muscle. Our results indicate the high potential applications of EGCG against WSSV in P. clarkii.

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Section: Discussionmentioning

confidence: 99%

Epigallocatechin‐3‐gallate inhibits replication of white spot syndrome virus in the freshwater crayfish Procambarus clarkii

Zhang

Wen

et al. 2021

Journal of Fish Diseases

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“…Western blot analysis revealed that ECG efficiently inhibited the replication of GCRV in CIK cells. Both EGCG and ECG have similar pharmacokinetic behaviour, and EGCG is partially converted to ECG in vivo 28 …”

Section: Antiviral Effect Of Medicinal Plants and Their Active Ingred...mentioning

confidence: 99%

“…Both EGCG and ECG have similar pharmacokinetic behaviour, and EGCG is partially converted to ECG in vivo. 28 And the ginsenoside Rg3 from ginseng showed an inhibitory effect on GCRV in grass carp ovarian (GCO) cells. 29 In this experiment, GCO cells were subjected to treatment with different concentrations of ginsenoside Rg3 (1, 10, and 100 μg/mL).…”

Section: Antiviral Effect Of Medicinal Plants and Their Active Ingred...mentioning

confidence: 99%

The antiviral activity of currently used medicinal plants in aquaculture and structure–activity relationship of their active ingredients

Zhang

Shan

et al. 2023

Reviews in Aquaculture

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Aquaculture is an important source of high‐quality protein and plays a crucial role in ensuring global food security. However, viral diseases have caused significant damage to aquaculture production, making it necessary to develop effective measures to treat them. Although drugs are commonly used to treat viral diseases, recent studies have shown that crude extracts of medicinal plants and their active ingredients have potential applications in the treatment of aquatic viral diseases. Furthermore, natural small molecule compounds from herbs could be used as lead compounds to develop more potent anti‐aquatic virus derivatives. As such, there is an urgent need to develop and apply drugs for the treatment of viral disease outbreaks in aquaculture. In this review, we summarize previous studies on the efficacy of different agents used as antiviral drugs in aquaculture, with a focus on their protective effects. Additionally, we highlight the potential of active natural compounds isolated from medicinal plants, which could serve as lead compounds for developing aquatic‐specific drugs. However, the relationship between the structure of a compound and its antiviral activity in aquaculture has not been clearly elucidated, posing a challenge for further drug optimisation. Therefore, this study also analyses the structure–activity relationship of several reported lead compounds and their derivatives in aquaculture, providing a reference for subsequent drug development efforts.

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“…Zhang et al [109] evaluated the effect of epicatechin-3-gallate (ECG) on GCRV in vitro, which differs from EGCG only in the absence of hydroxyl groups. ECG and EGCG have similar pharmacokinetic behavior, and EGCG is partially converted to ECG in vivo.…”

Section: Medicinal Plants Against Gcrvmentioning

confidence: 99%

Review of Medicinal Plants and Active Pharmaceutical Ingredients against Aquatic Pathogenic Viruses

Liao

Huang

Han

et al. 2022

Viruses

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Aquaculture offers a promising source of economic and healthy protein for human consumption, which can improve wellbeing. Viral diseases are the most serious type of diseases affecting aquatic animals and a major obstacle to the development of the aquaculture industry. In the background of antibiotic-free farming, the development and application of antibiotic alternatives has become one of the most important issues in aquaculture. In recent years, many medicinal plants and their active pharmaceutical ingredients have been found to be effective in the treatment and prevention of viral diseases in aquatic animals. Compared with chemical drugs and antibiotics, medicinal plants have fewer side-effects, produce little drug resistance, and exhibit low toxicity to the water environment. Most medicinal plants can effectively improve the growth performance of aquatic animals; thus, they are becoming increasingly valued and widely used in aquaculture. The present review summarizes the promising antiviral activities of medicinal plants and their active pharmaceutical ingredients against aquatic viruses. Furthermore, it also explains their possible mechanisms of action and possible implications in the prevention or treatment of viral diseases in aquaculture. This article could lay the foundation for the future development of harmless drugs for the prevention and control of viral disease outbreaks in aquaculture.

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(‐)‐Epicatechin gallate, a metabolite of (‐)‐epigallocatechin gallate in grass carp, exhibits antiviral activity in vitro against grass carp reovirus

Cited by 12 publications

References 21 publications

Epigallocatechin‐3‐gallate inhibits replication of white spot syndrome virus in the freshwater crayfish Procambarus clarkii

Epigallocatechin‐3‐gallate inhibits replication of white spot syndrome virus in the freshwater crayfish Procambarus clarkii

The antiviral activity of currently used medicinal plants in aquaculture and structure–activity relationship of their active ingredients

Review of Medicinal Plants and Active Pharmaceutical Ingredients against Aquatic Pathogenic Viruses

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