Epicatechin protects the auditory organ by attenuating cisplatin-induced ototoxicity through inhibition of ERK

Lee, J.S.; Kang, Sung Un; Hwang, Hye Sook; Pyun, Jung Hee; Choung, Yun‐Hoon; Kim, C.H.

doi:10.1016/j.toxlet.2010.09.013

Cited by 45 publications

(24 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with our results, a recent study has shown that inhibition of ERK activation in vivo attenuates cisplatin-induced ototoxicity and the associated hearing loss (Lee et al, 2010). Our experiments suggest a possible novel indication for bisphosphonates, i.e.…”

Section: Discussionsupporting

confidence: 93%

Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss

Kao¹,

Kempfle²,

Jensen³

et al. 2013

Neurobiology of Disease

View full text Add to dashboard Cite

Osteoprotegerin (OPG) is a key regulator of bone remodeling. Mutations and variations in the OPG gene cause many human diseases that are characterized by not only skeletal abnormalities but also poorly understood hearing loss: Paget’s disease, osteoporosis, and celiac disease. To gain insight into mechanisms of hearing loss in OPG deficiency, we studied OPG knockout (Opg −/−) mice. We show that they develop sensorineural hearing loss, in addition to conductive hearing loss due to abnormal middle-ear bones. OPG deficiency caused demyelination and degeneration of the cochlear nerve in vivo. It also activated ERK, sensitized spiral ganglion cells (SGC) to apoptosis, and inhibited proliferation and survival of cochlear stem cells in vitro, which could be rescued by treatment with exogenous OPG, an ERK inhibitor, or bisphosphonate. Our results demonstrate a novel role for OPG in the regulation of SGC survival, and suggest a mechanism for sensorineural hearing loss in OPG deficiency.

show abstract

Section: Discussionsupporting

confidence: 93%

Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss

Kao¹,

Kempfle²,

Jensen³

et al. 2013

Neurobiology of Disease

View full text Add to dashboard Cite

show abstract

“…Epicatechin protects against cisplatin-induced ototoxicity in a rat model, and inhibits activation of JNK, ERK, cytochrome c, and caspase-3 in a cochlear organ of Corti-derived cell line, HEI-OC1. 170 Quercetin has also been proposed to decrease the deleterious effects of cisplatin of cancer patients treated with this drug. In fact, it has been demonstrated to play a protective role in the abatement of cisplatin-induced clastogenesis and apoptosis in the bone marrow cells of mice.…”

Section: Toxicants and Drugsmentioning

confidence: 99%

Role of polyphenols in cell death control

Giovannini¹,

Masella²

2012

Nutritional Neuroscience

View full text Add to dashboard Cite

Dietary consumption of fruit, vegetables, fish, and olive oil has been demonstrated to exert beneficial effects on human health. This finding may be due to the high content of antioxidant compounds including polyphenols. Current evidence strongly supports a contribution of polyphenols to the prevention of several chronic degenerative diseases such as cancer, atherosclerosis and cardiovascular diseases, central nervous system disorders, as well as aging. Apoptosis is a genetically controlled and evolutionarily conserved form of cell death of critical importance for the maintenance of tissue homeostasis in the adult organism. The malfunction of the death machinery may play a primary role in various pathologic processes, leading to proliferative or degenerative diseases. Polyphenols can interact with specific steps and/or proteins regulating the apoptotic process in different ways depending on their concentration, the cell system, the type or stage of the pathological process. Because of their ability to modulate cell death, polyphenols have been proposed as chemopreventive and therapeutic agents. This paper reviews and discusses the last 3-year findings related to the principal molecular mechanisms involved in the control of the balance between apoptosis and cell proliferation exerted by polyphenols.

show abstract

“…Epicatechin exerts beneficial health-related effects since it acts as free radical scavengers and inhibitors of eicosainoid biosynthesis [9,10]. Epicatechin also reduces low-density lipoprotein in oxidation, risk of stroke, heart failure, cancer and diabetes [1,9,11,12].…”

Section: Introductionmentioning

confidence: 99%

Measurement and modeling of epicatechin solubility in supercritical carbon dioxide fluid

Soetaredjo

Ismadji

2013

Fluid Phase Equilibria

View full text Add to dashboard Cite

Epicatechin protects the auditory organ by attenuating cisplatin-induced ototoxicity through inhibition of ERK

Cited by 45 publications

References 61 publications

Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss

Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss

Role of polyphenols in cell death control

Measurement and modeling of epicatechin solubility in supercritical carbon dioxide fluid

Contact Info

Product

Resources

About