Epicutaneous sensitization with <i>Dermatophagoides farinae</i> induces generalized allergic dermatitis and elevated mite‐specific immunoglobulin E levels in a canine model of atopic dermatitis

Pucheu‐Haston, Cherie M.; Jackson, Hilary A.; Olivry, Thierry; Dunston, Stanley M.; Hammerberg, Bruce

doi:10.1111/j.1365-2222.2008.02949.x

Cited by 62 publications

(67 citation statements)

References 38 publications

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“…In AD, inflammation is characterised by an influx of CD4 + and CD8 + T cells in the lesional skin (Olivry et al, 1997;Sinke et al, 1997) and a mixed cytokine profile with predominant expression of IL-6, TARC, IL-4 and IL-13 genes in the early stage followed by IFN-c, IL-12 and IL-18 later on (Olivry et al, 1999;Nuttall et al, 2002;Marsella et al, 2006). Whereas most dogs with AD have circulating allergen-specific IgE (DeBoer and Hillier, 2001), there is controversial evidence for a similar reaction phenomenon in dogs with spontaneous manifestations of CAFRs (Jackson et al, 2003;Pucheu-Haston et al, 2008;Puigdemont et al, 2006). Increasing our insight in the immunopathogenesis of CAFRs may facilitate the development of novel modalities to treat them.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of T cell phenotypes, cytokines and transcription factors in the skin of dogs with cutaneous adverse food reactions

Veenhof

Knol

Schlotter

et al. 2011

The Veterinary Journal

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a b s t r a c tThe immunopathogenesis of cutaneous adverse food reactions (CAFRs) in dogs is unknown. Since the clinical manifestations in the skin are like those found in canine atopic dermatitis (AD), this study investigated the similarity in T cell phenotypes and gene expression of cytokines and transcription factors in CAFRs. In addition, the influence of an elimination diet on these parameters was tested.In the skin of canine CAFRs, a predominant presence of CD8 + T cells and increased expression of the IL-4, IL-13, Foxp3 and SOCS-3 genes were observed. IFN-c gene expression was increased in lesional compared to non-lesional skin. The predominance of CD8 + T cells indicates that the immunopathogenesis of CAFRs is different from that of canine AD. The elimination diet relieved clinical signs, but did not influence T cell phenotypes or expression of the cytokine and transcription factor genes in the skin of dogs with CAFRs, indicating a continuously pre-activated immune status in dogs sensitised to food constituents.

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Section: Introductionmentioning

confidence: 99%

Characterisation of T cell phenotypes, cytokines and transcription factors in the skin of dogs with cutaneous adverse food reactions

Veenhof

Knol

Schlotter

et al. 2011

The Veterinary Journal

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“…Recently, immunofluorescent staining for Der f 1 has demonstrated that mite allergens could infiltrate subepidermal sites after epicutaneous application of Der f slurry in a model of canine AD [19], which suggests that the defective epidermal barrier in atopic skin may enhance penetration of HDM. Furthermore, epicutaneous sensitization with HDM allergens has been shown to induce elevation of mite-specific IgE and pruritic dermatitis, resembling spontaneous AD in dogs [19]. Additionally, atopy patch testing with HDM enhanced mRNA transcription of cytokines (IL-6, IL-12p35, IL-13, IL-18 and IFN-) and a chemokine, TARC/CCL17, in lesional skin from high-IgE Beagles [12].…”

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confidence: 99%

Molecular Cloning of Canine Protease-Activated Receptor-2 and its Expression in Normal Dog Tissues and Atopic Skin Lesions

Maeda

Shibata

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. Protease-activated receptor-2 (PAR-2) belongs to a new G protein-coupled receptor subfamily and is activated by serine proteases. PAR-2 has been demonstrated to play an important role in inflammation and immune response in allergic diseases. In this study, we cloned canine PAR-2 cDNA from the canine kidney by RT-PCR. The canine PAR-2 clone contained a full-length open reading frame encoding 397 amino acids that had 84% and 80% homology with human and mouse homologues, respectively. Canine PAR-2 mRNA was detected in the heart, lung, liver, pancreas, stomach, small intestine, colon, kidney, adrenal gland, spleen, thyroid gland, thymus, skeletal muscle, lymph node, fat and skin of three healthy dogs. The expression pattern of PAR-2 mRNA in canine tissues was similar to that in humans. The expression level of PAR-2 mRNA in skin was not different between the atopic dermatitis (AD) and healthy dogs, suggesting that the level of PAR-2 mRNA transcription may not be associated with development of canine AD. The canine PAR-2 cDNA clone obtained in this study will be useful for further investigation of the immunopathogenesis of canine allergic diseases.

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“…In this model, pruritus and dermatitis can be elicited after epicutaneous application of house dust mites [75]. Lesions are consistent with naturally occurring AD lesions [76,77] making it a suitable model to test new therapies.…”

Section: Dog Models Of Atopic Dermatitismentioning

confidence: 99%

Animal Models of Allergic Diseases

Santoro

Marsella

2014

Veterinary Sciences

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Allergic diseases have great impact on the quality of life of both people and domestic animals. They are increasing in prevalence in both animals and humans, possibly due to the changed lifestyle conditions and the decreased exposure to beneficial microorganisms. Dogs, in particular, suffer from environmental skin allergies and develop a clinical presentation which is very similar to the one of children with eczema. Thus, dogs are a very useful species to improve our understanding on the mechanisms involved in people's allergies and a natural model to study eczema. Animal models are frequently used to elucidate mechanisms of disease and to control for confounding factors which are present in studies with patients with spontaneously occurring disease and to test new therapies that can be beneficial in both species. It has been found that drugs useful in one species can also have benefits in other species highlighting the importance of a comprehensive understanding of diseases across species and the value of comparative studies. The purpose of the current article is to review allergic diseases across species and to focus on how these diseases compare to the counterpart in people.

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Epicutaneous sensitization with Dermatophagoides farinae induces generalized allergic dermatitis and elevated mite‐specific immunoglobulin E levels in a canine model of atopic dermatitis

Cited by 62 publications

References 38 publications

Characterisation of T cell phenotypes, cytokines and transcription factors in the skin of dogs with cutaneous adverse food reactions

Characterisation of T cell phenotypes, cytokines and transcription factors in the skin of dogs with cutaneous adverse food reactions

Molecular Cloning of Canine Protease-Activated Receptor-2 and its Expression in Normal Dog Tissues and Atopic Skin Lesions

Animal Models of Allergic Diseases

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