Epidemic History of Hepatitis C Virus among Patients with Inherited Bleeding Disorders in Iran

Samimi-Rad, Katayoun; Rahimnia, Ramin; Sadeghi, Mahdi; Malekpour, Seyed Amir; Marzban, Mona; Keshvari, Maryam; Kiani, Seyed Jalal; Alavian, Seyed Moayed

doi:10.1371/journal.pone.0162492

Cited by 6 publications

(7 citation statements)

References 28 publications

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“…In the present study, the predominant genotype among HCV-infected patients was G3a which is in contrast with other studies enrolled in Iran, introducing mostly G1a as the most prevalent genotype of HCV [46][47][48]. However, this finding is consistent with Taherkhani et al [23] pointing out an increase in the frequency of infection with G3a in recent years and geographic predominance of this genotype in some parts of Iran.…”

Section: Discussionsupporting

confidence: 63%

Elevated serum levels of adiponectin and interlukin-28B after IFN/RIB therapy in hepatitis C virus-infected patients

Sadeghi

Vasmehjani

Baharlou

et al. 2019

J Infect Dev Ctries

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Introduction: The interleukin 28B (IL28B) genotype is associated with changes of lipid metabolism in patients infected with hepatitis C virus (HCV). The association of steatosis with serum levels of adiponectin in chronic hepatitis C (CHC) patients has also been documented. This study aimed for the evaluation of serum levels of IL28B and adiponectin as well as the association of IL28B SNPs with different clinicopathological parameters in HCV-infected patients. Methodology: All 142 HCV-infected patients received peg-interferon plus ribavirin. Detection of rs8099917 and rs12979860 IL-28B genotypes was done with specific primers. Serum IL28 and adiponectin levels were measured using commercial ELISA kits. Results: Higher levels of both IL28 and adiponectin were found in patients. In Genotype 3a (G3a) -infected patients, IL28 and adiponectin serum levels were significantly higher than those infected with G1a. A correlation was found between increasing levels of AST and ALT in G3a-infected patients and the decrease in IL28 and adiponectin serum levels, respectively, in contrast to G1a-infected patients. Higher levels of both IL28 and adiponectin were associated with both CT allele of rs12979860 and TT allele of rs8099917 in patients in comparison with corresponding alleles in controls. Conclusions: In contrast to other studies, this study showed higher serum adiponectin levels in HCV-infected patients compared to that in healthy controls. This finding is possibly due to adiponectin resistance caused by down-regulation of adiponectin receptors or tumorigenic effects of adiponectin. Our genotype-based analyses revealed, at least in part, the involvement of the viral factors in the outcome of HCV infection.

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Section: Discussionsupporting

confidence: 63%

Elevated serum levels of adiponectin and interlukin-28B after IFN/RIB therapy in hepatitis C virus-infected patients

Sadeghi

Vasmehjani

Baharlou

et al. 2019

J Infect Dev Ctries

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“…However, in the current study, no association was observed between distinct HCV genotype and age, or HCV risk factors such as IVDA or blood transfusion. On the other hand, recent studies showed that HCV genotype 3a in IVD abusers and HCV genotype 1a in patients receiving blood or blood products were the most common genotypes (14,(49)(50)(51)(52). As shown in Table 2, genotype 3a was not the most frequent genotype just in IVDA donors.…”

Section: Discussionmentioning

confidence: 88%

Distribution of Hepatitis C Virus Genotypes and Related Risk Factors Among Iranian Blood Donors: A Penalized Logistic Regression

Kermani

Amini-Kafiabad

Hosseini

et al. 2018

Jundishapur J Microbiol

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Background: The hepatitis C virus (HCV) is a blood born virus and the major cause of liver diseases worldwide. Distribution of HCV genotypes varies depending on geographical regions and routes of infection. Knowledge regarding the distribution of HCV genotypes and related risk factors plays an essential role in the control of HCV infection in the community. Objectives: The current study aimed at determining the current distribution of HCV genotypes and related risk factors among Iranian blood donors. Methods: In the current analytical, cross sectional study, 106 HCV-infected blood donors with detectable HCV RNA over the country were interviewed by trained physicians through a post-donation questionnaire on demographic, medical, and risk history from November 2015 to May 2017. The hepatitis C virus genotype was determined by sequencing of a segment of non-structural 5B region in HCV genome. Penalized logistic regression model was used for statistical analysis through STATA software. Results: Hepatitis C virus genotype was determined in all subjects, and the genotype 3a was the most frequent (65, 61.32%), followed by 1a (31, 29.25%), and 1b (10, 8.49%). Based on the multivariable analysis results, tattooing (adjusted odds ratio: 2.76; 95% confidence interval: 1.03-7.37) was associated with HCV genotype 3a. Conclusions: According to the results, it seems that changes in molecular epidemiology of HCV infection and replacement of HCV genotype 1a with 3a, characterized by an increase in genotype 3a and decrease in genotype 1a have occurred over the last decade among Iranian blood donors. Tattooing was an independent risk factor for HCV infection by genotype 3a.

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“…24 In a study by Katayoun Samimi in patients with inherited bleeding disorders 98.3% were found to be Hepaitis B negative almost comparable to present study. 25 In a study done in Pakistan in 2017 anti HCV antibody was positive in 18% and HBsAg was positive in 3% of patients. 26 Bloodborne viral infections are another potential complication of treatment in haemophiliacs.…”

Section: Discussionmentioning

confidence: 98%

Prevalence of transfusion transmitted infections in children with inherited coagulation disorders

Karya

Sarin

Mohammed

2018

Int J Contemp Pediatr

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Background: Factor replacement and blood product transfusion are the main stay of treatment of inherited coagulation disorders. Even though interventions with these products have led to the decrease in morbidity and mortality of these patients, repeated use of these products especially before 1980s where the viral inactivation of factors and blood bank screening methods were not stringent, have led to the occurrence of transfusion transmitted diseases in haemophiliacs especially hepatitis C infection.Methods: 50 children including adolescents under the age of 18 years with inherited coagulation disorders were screened for hepatitis B and C infection during 2 medical camps conducted at an interval of 6 months, blood samples and medical information were collected prospectively during these periods. The blood samples were tested for surrogate marker for hepatitis B and anti HCV using enzyme immunoassay.Results: All the children screened were negative for hepatitis B and C markers.Conclusions: The incidence of post transfusion hepatitis has dramatically decreased following stringent blood donor screening methods as well as availability of purified and recombinant factors. The current risk of transfusion transmitted infections in these patients are very low almost comparable with general population.

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Epidemic History of Hepatitis C Virus among Patients with Inherited Bleeding Disorders in Iran

Cited by 6 publications

References 28 publications

Elevated serum levels of adiponectin and interlukin-28B after IFN/RIB therapy in hepatitis C virus-infected patients

Elevated serum levels of adiponectin and interlukin-28B after IFN/RIB therapy in hepatitis C virus-infected patients

Distribution of Hepatitis C Virus Genotypes and Related Risk Factors Among Iranian Blood Donors: A Penalized Logistic Regression

Prevalence of transfusion transmitted infections in children with inherited coagulation disorders

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