Epidemic (Lethargic) Encephalitis

Thalhimer, William

doi:10.1001/archneurpsyc.1922.02190150064004

Cited by 4 publications

(5 citation statements)

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“…1 to 16 illustrating the present paper, it will be observed that the same kind of lesions can occur in supposedly healthy animals, or in those employed for a variety of experimental purposes other than for intracerebral inoculation. A further comparison may be made with the photographs of similar conditions in animals free from the so called encephalitic virus presented by Bull and by Oliver 4 and to which reference has already been made.…”

Section: Cultivation Testsmentioning

confidence: 96%

“…12 to 17) of brains from rabbits which succumbed to bacillary infection or were killed during a streptococcus infection, in which the perivascular infiltration, the meningitis, and the focal necrotic lesions are definitely exhibited. So does Oliver, 4 whose illustrations (Figs. 1 and 2) of meningeal, perivascular, and cerebral necrotic lesions were taken from supposedly healthy rabbits of the laboratory stock.…”

Section: Cultivation Testsmentioning

confidence: 99%

“…It was at Dr. Flexner's suggestion that, along with certain cultivation studies which were being made with the so called viruses of epidemic encephalitis and febrile herpes, 2 I undertook the examination of a large number of rabbit brains for the presence of lesions previously described by Bull 3 and Oliver 4 as existing in these animals before experimental inoculations had been made. The rabbits studied were taken from many sources-the laboratory stock regarded as healthy, others dying of snuffles and affections while under observation preparatory to experimental use, as well as animals which were employed for experimental purposes (tumor transplantation, Treponema pallidum inoculation, etc.).…”

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Brain Lesions of the Domestic Rabbit

McCartney

1924

Journal of Experimental Medicine

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Lesions of meningoencephalitis were found in 55 per cent of 372 rabbits comprising the laboratory stock regarded as healthy, others with snuffles or dying from different affections while being kept under observation, and still others which were employed for experimental purposes, such as tumor transplantation and Treponema pallidum inoculation. None was injected intracerebrally. The lesions consist in the main of infiltration with mononuclear cells occurring around the blood vessels, in the meninges, in the cortex, and under the ependyma of the lateral ventricles, together with particular focal necrotic areas in the cortex. The incidence of these histopathological changes varies in different series of animals; in those supposedly normal and in rabbits inoculated with a transplantable tumor or with Treponema pallidum material, the percentage of positives was from 40 to 60; in those suffering from miscellaneous diseases, such as pneumonia, septicemia, etc., the percentage was 70, and in rabbits ill with snuffles, as many as 76 per cent were affected. Marked lesions were observed in 47.5 per cent of the total. The histopathological picture observed in these rabbits corresponds to those offered by a number of investigators as evidence of the transmission of certain nervous diseases of man to this animal. The accidental cerebral lesions in the rabbit, of a wide variety, and of frequent occurrence, are to be regarded as existing before any experimental procedure is begun. Their recognition is of the utmost importance in the interpretation of experimental results based on the presence of similar changes in this animal.

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Section: Cultivation Testsmentioning

confidence: 96%

Section: Cultivation Testsmentioning

confidence: 99%

mentioning

confidence: 99%

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Brain Lesions of the Domestic Rabbit

McCartney

1924

Journal of Experimental Medicine

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“…TlIe effect on the latter tracts was to abolish the reflex tonus of the palsiedl extensor muscles without interfering with the reflex activity of the paralysed flexor groups. (2) A case showing that even a large bedsore could recover if the cause of the palsy was effectively tackled. The man had syphilitic meningo.…”

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confidence: 99%

“…C. WOiISTER-DROUGHT (London) dealt with the practical difficulties that arose in the differential diagnosis of lesions involving the lower cervical and upper dorsal regions of the spinal cord; more especially between (1) compression of the cord, by pachymeningitis or tumour, and syringomyelia with local undissociated anaesthesia and " central "' pain; (2) intramedullary tumour and syringomyelia with Brown-Sdquard syndrome; (3) early compression paraplegia without sensory changes and a pure spinal type of disseminated sclerosis.…”

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confidence: 99%