Epidemic neuropathy in Cuba: Morphological characterization of peripheral nerve lesions in sural nerve biopsies

Borrajero, Israel; Pérez, Julio; Domínguez, Carlos; Chong, Agustín; Coro, Rosa María; Rodríguez, Héctor Hernández; Gómez, N. Muelas; Román, Gustavo C.; Navarro-Román, Lydia

doi:10.1016/0022-510x(94)90137-6

Cited by 34 publications

(6 citation statements)

References 10 publications

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“…The monoculture for sugar-cane in Cuba persisted until the production of vegetables, potatoes, pineapples, grapefruit, oranges and other citrus fruits was introduced in the seventies. The habitual consumption of oranges may, therefore, have developed only recently, perhaps encouraged by the restrictions imposed upon many basic foods following the embargo of 1990 known in the Cuban medical literature as`P eriodico especial'' (37). Families may have attempted to compensate for any shortfall in calories and vitamins with its predictable consequences by providing brown sugar and citrus fruit.…”

Section: Dental Erosion Dmftmentioning

confidence: 99%

Dental erosion in Cuban children associated with excessive consumption of oranges

Künzel

Cruz

Fischer

2000

European J Oral Sciences

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Marked erosion at the mesial edges of upper front teeth was observed during an examination of Cuban children. The preferential erosion of mesial edges produced characteristic V-shaped defects on upper central incisors, and the aim of the present study, carried out on 12-yr-old children (N = 1010) in 10 communities in the Province of Havana was to establish the frequency of dental erosion and explain its occurrence. The symmetrical erosion of teeth 11 and 21 (excluding crown injuries and attrition) were clinically classified into four grades: 0.5 = objectionable; 1 = abnormal mesial shortening of incisal edges; 2 = V-shaped defect of cutting edges; 3 = exposure of dentine and extension of the erosive defect to the lateral incisors. In four of the communities, children did not show or rarely showed incisal erosion. In the other six communities, the frequency was surprisingly high (16.6-40.9%). Overall, 17.4% of children exhibited erosion, and the occurrence was significantly higher in girls (20.7%) than in boys (15.0%). The typical V-shaped pattern of erosion seems to be a consequence of the manner in which citrus fruits are eaten. There was also a positive correlation between the frequency of dental erosion and the proximity of citrus plantations, which presumably related to the extent of (daily) orange consumption.

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Section: Dental Erosion Dmftmentioning

confidence: 99%

Dental erosion in Cuban children associated with excessive consumption of oranges

Künzel

Cruz

Fischer

2000

European J Oral Sciences

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“…It is likely that the recent epidemics of nutritional neuropathies observed in the Caribbean and Cuba are variations of the same syndrome. 17,104,167 The syndrome is speculated to result from distal degeneration of both central and peripheral processes of sensory neurons. Distal sensory loss, hyporeflexia at the ankles, hyperreflexia at the knees, and gait ataxia occur.…”

mentioning

confidence: 99%

Neuromuscular diseases and disorders of the alimentary system

2002

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This review outlines the relationship and interaction between neuromuscular diseases and disorders of the alimentary system. Neuromuscular manifestations of gastrointestinal and hepatobiliary diseases are first considered. Such diseases may cause neuromuscular disorders by leading to nutritional deficiency or by more direct mechanisms. The pathogenesis, clinical features, and treatment of these various neuromuscular manifestations are discussed. The impact of disorders of nerve, neuromuscular transmission, and muscle on the alimentary system is then reviewed. The main sequelae are impaired deglutition and gastrointestinal dysmotility. The management of these complications is considered.

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“…Sural nerve biopsies in patients with the Cuban epidemic neuropathy showed axonal damage in large diameter myelinated nerve fibres. 7 Our findings of impaired parasympathetic cardiac modulation suggest neurophysiological involvement of small nerve fibres as well. This is supported by previous findings of impaired thermal thresholds in these patients.…”

Section: Discussionmentioning

confidence: 60%

High blood pressure and decreased heart rate variability in the Cuban epidemic neuropathy

Gutiérrez

Santiesteban²,

Garcia³

et al. 2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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Epidemic neuropathy in Cuba: Morphological characterization of peripheral nerve lesions in sural nerve biopsies

Cited by 34 publications

References 10 publications

Dental erosion in Cuban children associated with excessive consumption of oranges

Dental erosion in Cuban children associated with excessive consumption of oranges

Neuromuscular diseases and disorders of the alimentary system

High blood pressure and decreased heart rate variability in the Cuban epidemic neuropathy

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