Epidemic Occurrence of Neonatal Necrotizing Enterocolitis

Guinan, Mary; Schaberg, Dennis R.; Bruhn, Frederic W.; Richardson, Carol; Fox, William W.

doi:10.1097/00006254-198002000-00012

Cited by 13 publications

(27 citation statements)

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“…However, one would not expect viruses to affect only premature infants and thus a viral influence would theoretically result in more term infants with NEC. Correspondingly, infants affected by epidemic NEC were found to have higher birth weights and Apgar scores, fewer perinatal complications, later onset, and better outcome in a retrospective case-controlled study [10].…”

Section: Discussionmentioning

confidence: 93%

“…The 6-month periodicity was statistically significant with probability of random distribution being 6.38 9 10 -7 colonization has been reported, with isolation of Escherichia coli and Klebsiella pneumoniae from upper and lower gastrointestinal sources [9]. Many authors have described epidemics of NEC related to specific pathogens [10][11][12][13]. Others have reported epidemics for which no infectious agent can be identified [14].…”

Section: Discussionmentioning

confidence: 99%

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Seasonal variation in the incidence of necrotizing enterocolitis

et al. 2010

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Seasonal variation in the incidence of necrotizing enterocolitis

et al. 2010

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“…In addition, Guinam et al [18] found no particular risk factor to be associ ated with the affected infants. Antibiotic treatment was associated with decreased risk or a later onset of the disease.…”

Section: Discussionmentioning

confidence: 98%

Necrotizing Enterocolitis in Full-Term Newborns

Gamarra¹,

Helardot²,

Moriette³

et al. 1983

Neonatology

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During a 17-month period, 19 full-term newborn infants were hospitalized for necrotizing enterocolitis (NEC). 10 of these infants had no apparent risk factors. Only 7 suffered acute fetal distress. 16 of the 19 infants were born in the same hospital. Toxicological and bacteriological investigations of possible cause revealed no specific agent. Virological analysis of 8 stool samples revealed the presence of corona virus in 5 of the 8.

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“…and May 31,1985 were compared with matched controls. The study period included a cluster (epidemic) of 11 cases diagnosed within 1 month.…”

mentioning

confidence: 99%

Necrotizing Enterocolitis: Feeding in Endemic and Epidemic Periods

Zabielski

Groh-Wargo

Moore

1989

J Parenter Enteral Nutr

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Aggressive feeding practices are thought to increase the incidence of necrotizing enterocolitis (NEC). Detailed feeding histories of the 39 cases occurring between January 1, 1984 and May 31, 1985 were compared with matched controls. The study period included a cluster (epidemic) of 11 cases diagnosed within 1 month. Data were analyzed collectively and separately for endemic and epidemic cases. Collectively, cases had greater average daily intake volume, maximum daily intake volume, intake volume on the day prior to diagnosis, and maximum daily caloric intake (all p less than 0.05) than controls. The only recorded parameter that differed in endemic cases vs controls was intake the day prior to diagnosis. In contrast, epidemic cases were fed significantly more volume, more calories, and faster than controls: average intake volume (62.5 +/- 27.2 vs 37.4 +/- 18.0 ml/kg/day); maximum intake volume (118.5 +/- 33.5 vs 76.4 +/- 38.8 ml/kg/day); intake day prior to diagnosis (109.8 +/- 30.9 vs 63.8 +/- 43.1 ml/kg/day); maximum daily increment (42.6 +/- 16.7 vs 26.7 +/- 16.4 ml/kg); maximum caloric intake (126.1 +/- 44.6 vs 77.3 +/- 50.0) (all p less than 0.01). Five of the feeding parameters were significantly less for the epidemic controls than the endemic controls, suggesting a general slowing of feeding during the NEC epidemic. In summary, the data suggest feeding patterns may have an impact on NEC especially during epidemic periods.

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Epidemic Occurrence of Neonatal Necrotizing Enterocolitis

Cited by 13 publications

References 0 publications

Seasonal variation in the incidence of necrotizing enterocolitis

Seasonal variation in the incidence of necrotizing enterocolitis

Necrotizing Enterocolitis in Full-Term Newborns

Necrotizing Enterocolitis: Feeding in Endemic and Epidemic Periods

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