Ecuador has shown a growth in its scientific production since 2011, representing 85% of the total historical production. These investigations are reflected in scientific publications, which address world interest topics and serve as a link for the university, business, and society. This work aims to analyze the scientific production generated by Ecuador in the period of 1920–2020 using bibliometric methods to evaluate its intellectual structure and performance. The methodology applied in this study includes: (i) terms definition and search criteria; (ii) database selection, initial search, and document compilation; (iii) data extraction and software selection; and finally, (iv) analysis of results. The results show that scientific production has been consolidated in 30,205 documents, developed in 27 subject areas, in 13 languages under the contribution of 84 countries. This intellectual structure is in harmony with the global context when presenting research topics related to “Biology and regional climate change”, “Higher education and its various approaches”, “Technology and Computer Science”, “Medicine”, “Energy, food and water”, and ”Development and applications on the Web”. Topics framed in the Sustainable Development Goals (SDGs), sustainability, climate change, and others. This study contributes to the academic community, considering current re-search issues and global concerns, the collaboration between universities and countries that allow establishing future collaboration links.