Epidemiología del cáncer de tiroides en un Instituto Oncológico. Efecto de las nuevas recomendaciones clínicas

Z, Jorge Sapunar; Ferrer-Rosende, Pedro

doi:10.4067/s0034-98872020000500573

Cited by 4 publications

(7 citation statements)

References 15 publications

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“…Thus, as the recognition of nuclear alterations in PTC increased, the incidence of FTC decreased, with PTC currently being the most frequently diagnosed thyroid cancer ( 4 – 6 ). Chilean studies have found a similar situation, where 91.8%-96.3% of the thyroid cancers are PTC and only 2.4%-5.1% are FTC ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 69%

Clinical and histopathological features of follicular thyroid cancer in Chile

Díaz¹,

Domínguez²,

Tala³

et al. 2023

Archives of Endocrinology and Metabolism

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Objective: Follicular thyroid carcinoma (FTC) is less frequent but has a worse prognosis than papillary carcinoma. The available evidence on pre-operative characteristics of FTC is controversial. Our objective was to characterize the clinical, ultrasound and histopathological presentation of FTC patients treated Chile. Subjects and methods: Retrospective analysis of 97 patients treated for FTC in 6 large centers in Chile. We analyzed their ultrasonographic features and classified the nodules according to ATA risk of malignancy and TI-RADS score, as well as the cytological findings according to the Bethesda system. We described their clinical and histopathological findings at diagnosis and classified their risk of recurrence and mortality according to ATA 2015 recurrence risk category and the eighth edition of the AJCC/UICC staging system, respectively. Results: Median age was 48 years and 73.2% were females. The median diameter was 38.8 mm; only 9.5% of them were microtumors. According to ATA risk of malignancy, 86% of the nodules were low or intermediate suspicious, while 78% were category 3 or 4A nodules according to the TI-RADS. Regarding the Bethesda system, 65.9% had indeterminate cytology (20.6% category III and 45.3% category IV). At histological examination, most were minimally-invasive and angio-invasive tumors with less than 4 foci (54.7% and 28.4% respectively). More than 90% of FTC were unifocal and there was no lymphovascular or extrathyroidal invasion or lymph node involvement. Four patients (4.1%) had distant metastases at diagnosis. Most patients (95%) had stage I or II disease according to the AJCC/UICC staging system, while the risk of recurrence was low at 51.5% when using the ATA risk of recurrence scale. Conclusions: At diagnosis, most FTCs were nodules of low or intermediate suspicion at ultrasound, nearly two thirds had indeterminate cytology according to the Bethesda system, and nearly 50% of them were of low risk of recurrence.

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Section: Introductionmentioning

confidence: 69%

Clinical and histopathological features of follicular thyroid cancer in Chile

Díaz¹,

Domínguez²,

Tala³

et al. 2023

Archives of Endocrinology and Metabolism

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“…The following four criteria were required for each study: (1) the study design must be a clinical cohort study or diagnostic test; (2) the study must relate to the accuracy of S-Detect for the PLOS ONE differential diagnosis of benign and malignant thyroid nodules,and the final assessments from S-Detect were in dichotomized form: possibly benign and possibly malignant; (3) all thyroid nodules were histologically confirmed; and(4) published data in the fourfold (2×2) tables must be sufficient. If the study did not meet all the inclusion criteria, it was excluded.…”

Section: Selection Criteriamentioning

confidence: 99%

“…The QUADAS criteria include 14 assessment items. Each item was scored as "yes" (2), "no" (0), or "unclear" (1). The QUADAS score ranged from 0 to 28, and a score � 22 indicated good quality.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…In the past period, the incidence rate of thyroid related diseases is increasing, which is closely related to the progress in biological characteristics and ultrasound diagnosis technology [1]. For the clinical diagnosis of this disease, ultrasonic examination method is usually selected, and its main advantage is that it has very high sensitivity [2].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of S-Detect in distinguishing benign and malignant thyroid nodules: A meta-analysis

Zhong

Wang

2022

PLoS ONE

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Objectives In this meta-analysis study, the main objective was to determine the accuracy of S-detect in effectively distinguishing malignant thyroid nodules from benign thyroid nodules. Methods We searched the PubMed, Cochrane Library, and CBM databases from inception to August 1, 2021. Meta-analysis was conducted using STATA version 14.0 and Meta-Disc version 1.4 softwares. We calculated summary statistics for sensitivity (Sen), specificity (Spe), positive and negative likelihood ratio (LR+/LR−), diagnostic odds ratio(DOR), and receiver operating characteristic (SROC) curves. Cochran’s Q-statistic and I2 test were used to evaluate potential heterogeneity between studies. A sensitivity analysis was performed to evaluate the influence of single studies on the overall estimate. We also performed meta-regression analyses to investigate the potential sources of heterogeneity. Results In this study, a total of 17 studies meeting the requirements of the standard were used. The number of benign and malignant nodules analyzed and evaluated in this paper was 1595 and 1118 respectively. This paper mainly completes the required histological confirmation through s-detect. The pooled Sen and pooled Spe were 0.87 and 0.74, respectively, (95%CI = 0.84–0.89) and (95%CI = 0.66–0.81). Furthermore, the pooled LR+ and negative LR− were determined to be 3.37 (95%CI = 2.53–4.50) and 0.18 (95%CI = 0.15–0.21), respectively. The experimental results showed that the pooled DOR of thyroid nodules was 18.83 (95% CI = 13.21–26.84). In addition, area under SROC curve was determined to be 0.89 (SE = 0.0124). It should be pointed out that there is no evidence of bias (i.e. t = 0.25, P = 0.80). Conclusions Through this meta-analysis, it can be seen that the accuracy of s-detect is relatively high for the effective distinction between malignant thyroid nodules and benign thyroid nodules.

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“…De hecho, el cáncer de tiroides es uno de los tipos de neoplasias que ha aumentado en los últimos ocho años (Veronica, 2018). En Manabí el cáncer de tiroides tanto en hombres como en mujeres ocupa el segundo lugar a nivel nacional después de Pichincha, seguido por Azuay, Guayaquil y Loja, según registros existentes en SOLCA (Sapunar Z & Ferrer-Rosende, 2020). Los factores de riesgo que se asocian con el cáncer de tiroides, además de la exposición a radiación, la obesidad, el sedentarismo, la diabetes mellitus tipo II, contaminantes químicos como bisfenol A, cadmio, la baja ingesta de yodo, la ingesta excesiva de nitritos y factores reproductivos en la mujer (Sapunar Z & Ferrer-Rosende, 2020).…”

Section: Introductionunclassified

Prevalencia, factores de riesgo y diagnóstico del cáncer de tiroides en la población de América Latina

Bravo-Villalta,

Zambrano-Rodríguez,

Durán-Cañarte

2024

MQRInvestigar

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El cáncer de tiroides es la malignidad más común que afecta al sistema endocrino, y en las últimas décadas, se ha observado un aumento progresivo de su aparición en múltiples regiones y países alrededor del mundo. El objetivo principal es analizar la prevalencia y pruebas de diagnóstico del cáncer de tiroides en la población de América Latina. Metodología: Revisión de tipo narrativo documental. Se llevó a cabo con bases de datos como; Scielo, Pubmed, Medigraphic, Elseiver. Los resultados resaltan la prevalencia del cáncer de tiroides entre países, como Argentina teniendo la tasa más alta y Perú la más baja. La ecografía y la biopsia por punción son las pruebas de diagnóstico más comunes en todos los países, mientras que Chile y Uruguay también utilizan la gammagrafía tiroidea. Además, se identifican factores de riesgo comunes como la exposición a la radiación y los antecedentes familiares, junto con otros como la dieta, la edad, el sexo, factores hormonales, sobrepeso, consumo de tabaco, deficiencia de yodo, nódulos tiroideos y enfermedades autoinmunes. Finalmente, la prevalencia de cáncer de tiroides en América Latina tiene un espectro que podría ir de 0.010% A 0,50% aprox por cada 100000 habitantes, las pruebas de diagnóstico más utilizadas en la población de América Latina para el cáncer de tiroides son la ecografía de tiroides y la biopsia por punción con aguja fina, los factores de riesgo asociados al cáncer de tiroides en la población de América Latina, son la exposición a la radiación, la dieta y los antecedentes familiares.

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Epidemiología del cáncer de tiroides en un Instituto Oncológico. Efecto de las nuevas recomendaciones clínicas

Cited by 4 publications

References 15 publications

Clinical and histopathological features of follicular thyroid cancer in Chile

Clinical and histopathological features of follicular thyroid cancer in Chile

Diagnostic accuracy of S-Detect in distinguishing benign and malignant thyroid nodules: A meta-analysis

Prevalencia, factores de riesgo y diagnóstico del cáncer de tiroides en la población de América Latina

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