Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha, China

Yu, Tanlai; Tan, Bo; Pan, Jia Hua; Wu, Jing; Zeng, Sai zhen; Wei, Hong

doi:10.1016/j.jcv.2020.104353

Cited by 122 publications

(131 citation statements)

References 9 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…Ninety‐two articles (of which four included pregnant patients) reported adult patients infected with SARS‐CoV‐2. Eleven articles included paediatric population, and four articles reported both adults and children infected with SARS‐CoV‐2 2,7,14‐118 . (Tables S1, S2 and S3) A total of 20 874 patients were included, of which 38 were pregnant patients, 395 were paediatric patients and the rest were adult patients.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic review with meta‐analysis: liver manifestations and outcomes in COVID‐19

Kulkarni

Kumar

Tevethia

et al. 2020

Aliment Pharmacol Ther

222

310

View full text Add to dashboard Cite

Summary Background The incidence of elevated liver chemistries and the presence of pre‐existing chronic liver disease (CLD) have been variably reported in COVID‐19. Aims To assess the prevalence of CLD, the incidence of elevated liver chemistries and the outcomes of patients with and without underlying CLD/elevated liver chemistries in COVID‐19. Methods A comprehensive search of electronic databases from 1 December 2019 to 24 April 2020 was done. We included studies reporting underlying CLD or elevated liver chemistries and patient outcomes in COVID‐19. Results 107 articles (n = 20 874 patients) were included for the systematic review. The pooled prevalence of underlying CLD was 3.6% (95% CI, 2.5‐5.1) among the 15 407 COVID‐19 patients. The pooled incidence of elevated liver chemistries in COVID‐19 was 23.1% (19.3‐27.3) at initial presentation. Additionally, 24.4% (13.5‐40) developed elevated liver chemistries during the illness. The pooled incidence of drug‐induced liver injury was 25.4% (14.2‐41.4). The pooled prevalence of CLD among 1587 severely infected patients was 3.9% (3%‐5.2%). The odds of developing severe COVID‐19 in CLD patients was 0.81 (0.31‐2.09; P = 0.67) compared to non‐CLD patients. COVID‐19 patients with elevated liver chemistries had increased risk of mortality (OR‐3.46 [2.42‐4.95, P < 0.001]) and severe disease (OR‐2.87 [95% CI, 2.29‐3.6, P < 0.001]) compared to patients without elevated liver chemistries. Conclusions Elevated liver chemistries are common at presentation and during COVID‐19. The severity of elevated liver chemistries correlates with the outcome of COVID‐19. The presence of CLD does not alter the outcome of COVID‐19. Further studies are needed to analyse the outcomes of compensated and decompensated liver disease.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Seventy‐six articles, including 13 141 patients, described elevated liver chemistries at initial presentation 7,14‐34,46,47,49‐52,54‐75,77‐84,86,88‐93,102‐112 . The incidence of elevated liver chemistries varied from 1.1% to 68% in COVID‐19 patients 84,89 .…”

Section: Resultsmentioning

confidence: 99%

Systematic review with meta‐analysis: liver manifestations and outcomes in COVID‐19

Kulkarni

Kumar

Tevethia

et al. 2020

Aliment Pharmacol Ther

222

310

View full text Add to dashboard Cite

show abstract

“…The SARS outbreak in 2003 revealed that knowledge, attitude, and practice (KAP) play equally important roles in the prevention and control of an outbreak. Therefore, many researchers have conducted surveys to investigate the outbreak-related KAP of the general public in China during the outbreak in order to identify gaps for prevention and control and provide a theoretical basis for the development of targeted prevention and control measures [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude, and Practice of Nurses Towards the Prevention and Control of COVID-19

Jin

Luo

Lei

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Coronavirus disease 2019(COVID-19) has been spreading globally, with severe impacts on health and economies. Nursing is an essential component of medical care, and nurses’ knowledge, attitude, and practice (KAP) about the prevention and control of the disease directly affects patient’s outcomes ,but there is little know about the nurses’ KAP during the COVID-19 epidemic.Methods: An anonymous survey was conducted using customized questionnaires designed by Sojump platform. 1323 nurses in Wuhan were the survey object for the KAP survey. The survey included 48 questions regarding the basic information of nurses and knowledge, attitude, and prevention measures for COVID-19. Results: A total of 1323 nurses in Wuhan were included in the survey, of whom women (95.7%) under 40 years old (94.6%) accounted for the majority. Nurses have a comprehensive knowledge of problems such as the COVID-19 susceptible population, isolation ward layout process, environmental cleaning and disinfection, hand hygiene measures, infectious disease case reporting processes, standard prevention measures, and personal protection level, with more than 60% accuracy. However, they have a general lack of knowledge about the route of transmission of COVID-19, the use of protective equipment, patient management, medical waste disposal, and occupational exposure emergency response, with less than 45% accuracy. There was a gap between the attitude and the practice of nurses (p <0.05). Moreover, the knowledge level of nurses has an impact on their attitude (OR 1.52, 95% CI 1.10-2.08, p = 0.008), and title (OR 1.48, 95% CI 1.01-2.15, p = 0.042), place of work (OR 1.59, 95% CI 1.36-1.85, p <0.001), and attitude (OR 1.93, 95% CI 1.52-2.46, p <0.001) had an impact on their practice.Conclusion: The nurses in Wuhan during the epidemic have insufficient knowledge about COVID-19 infection prevention and control, and there are gaps in attitude and practice, which further affect their attitude and practice. It is therefore necessary to strengthen relevant knowledge training on COVID-19 among nurses.

show abstract

“…13 Table 2 shows the comparison of clinical features between the two diseases in children from different studies. [14][15][16][17][18][19][20][21] While fever and cough remained the most prominent symptoms, relatively low prevalence in chest pain/discomfort, and dyspnea was observed in both diseases, suggestive of less common lower respiratory tract infection in children.…”

Section: Resultsmentioning

confidence: 97%

Clinical characteristics of COVID‐19 in children: Are they similar to those of SARS?

Leung

2020

Pediatric Pulmonology

View full text Add to dashboard Cite

Although the number of SARS‐CoV‐2 infections has been rising amid the current pandemic of COVID‐19, the low infection rate of SARS‐CoV‐2 in children has been low. By examining the clinical data available in the public domain, the present work clarifies the clinical presentations in children with COVID‐19 in China. Statistical significance tests and adjusted odds ratios estimation were performed on the children (age below 18) and adults (age 18 or above) cohorts in China. SARS‐CoV and SARS‐CoV‐2 shared similar clinical features. Lower respiratory tract infection was less prominent in children as evidenced by the relatively low prevalence in chest pain/discomfort and dyspnea. Similar to SARS, younger children had a less aggressive clinical course, compared with adolescents. While fewer symptoms were observed in children compared to adults, there is not yet sufficient evidence to conclude shorter hospital stay in children.

show abstract

Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha, China

Cited by 122 publications

References 9 publications

Systematic review with meta‐analysis: liver manifestations and outcomes in COVID‐19

Systematic review with meta‐analysis: liver manifestations and outcomes in COVID‐19

Knowledge, Attitude, and Practice of Nurses Towards the Prevention and Control of COVID-19

Clinical characteristics of COVID‐19 in children: Are they similar to those of SARS?

Contact Info

Product

Resources

About