Epidemiologic association between prostatitis and prostate cancer

Dennis, Leslie K.; Lynch, Charles F.; Torner, James C.

doi:10.1016/s0090-4295(02)01637-0

Cited by 341 publications

(255 citation statements)

References 24 publications

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“…Our overall null study finding for clinical prostatitis is consistent with findings from eight previous case-control studies of clinical prostatitis and prostate cancer (7,12,15,19,(29)(30)(31)(32) but differs from those from an additional nine casecontrol studies and meta-analysis results (3,8,9,13,17,22,23,28). One methodologic concern for positive studies is detection bias, whereby men with a history of prostatitis may be followed more closely for prostate cancer than men without such a history, due to ongoing investigations for chronic prostatitis or closer medical contact following a diagnosis of prostatitis.…”

Section: Discussionsupporting

confidence: 86%

Gonorrhea, Syphilis, Clinical Prostatitis, and the Risk of Prostate Cancer

Sutcliffe

Giovannucci

Marzo

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Although previous case-control studies have observed positive associations among gonorrhea, syphilis, clinical prostatitis, and prostate cancer, many may have been susceptible to recall and interviewer biases due to their retrospective designs. Therefore, to investigate these associations without concerns of recall and interviewer biases, we conducted a large, prospective investigation in the Health Professionals Follow-up Study. Methods: In 1992, participants were asked to report their histories of gonorrhea, syphilis, and clinical prostatitis by mailed questionnaire. Prostate cancer diagnoses were ascertained by self-report on the 1994 and each subsequent biennial follow-up questionnaire and confirmed by medical record review. Results: Of the 36,033 participants in this analysis, 2,263 were diagnosed with prostate cancer between the date of return

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Section: Discussionsupporting

confidence: 86%

Gonorrhea, Syphilis, Clinical Prostatitis, and the Risk of Prostate Cancer

Sutcliffe

Giovannucci

Marzo

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Dennis et al [17] reported that a medical history of prostatitis was positively correlated with PCa (OR = 1.6), in a meta-analysis that included 11 case-control studies. Moreover, Roberts et al [18] examined the correlation of acute, chronic and non-bacterial prostatitis with PCa.…”

Section: Discussionmentioning

confidence: 99%

Prostate calculi in cancer and BPH in a cohort of Korean men: presence of calculi did not correlate with cancer risk

Hwang¹,

Choi²,

Im³

et al. 2009

Asian J Androl

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Prostatic calculi are common and are associated with inflammation of the prostate. Recently, it has been suggested that this inflammation may be associated with prostate carcinogenesis. The aim of this study was to investigate the relationship between prostatic calculi and prostate cancer (PCa) in prostate biopsy specimens. We retrospectively analyzed 417 consecutive patients who underwent transrectal ultrasonography (TRUS) and prostate biopsies between January 2005 and January 2008. Based on the biopsy findings, patients were divided into benign prostatic hyperplasia and PCa groups. TRUS was used to detect prostatic calculi and to measure prostate volume. The correlations between PCa risk and age, serum total PSA levels, prostate volume, and prostatic calculi were analyzed. Patient age and PSA, as well as the frequency of prostatic calculi in the biopsy specimens, differed significantly between both the groups (P < 0.05). In the PCa group, the Gleason scores (GSs) were higher in patients with prostatic calculi than in patients without prostatic calculi (P = 0.023). Using multivariate logistic regression analysis, we found that patient age, serum total PSA and prostate volume were risk factors for PCa (P = 0.001), but that the presence of prostatic calculi was not associated with an increased risk of PCa (P = 0.13). In conclusion, although the presence of prostatic calculi was not shown to be a risk factor for PCa, prostatic calculi were more common in patients with PCa and were associated with a higher GS among these men.

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“…in 2002, a meta-analysis by Dennis and coworkers performed on 11 studies, including a total of 1,648 cancer cases and 1,824 controls, found a significant association between a clinical history of prostatitis and PCa, with an OR of 1.6 (95% CI 1.01-2.45), increased to 1.8 (95% CI 1.05-2.98) when the analysis was restricted to population-based case-control studies (20). Although the authors admit the possible confounding influence of detection and recall biases in the analyzed studies, these data point to a potential role of a history of symptomatic prostate inflammation in subsequent cancer development.…”

Section: Clinical and Epidemiological Studiesmentioning

confidence: 99%

Inflammation, prostatitis, proliferative inflammatory atrophy: ‘Fertile ground’ for prostate cancer development?

Perletti¹,

Montanari

Vral³

et al. 2009

Mol Med Rep

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Abstract. Inflammatory processes caused by chemical, physical or biological agents are known to be important cofactors in the pathogenesis of human cancer. In the prostate, epithelial tissue damage followed by cell regeneration in the presence of inflammation is believed to be a key event in neoplastic transformation. According to the 'injury and regeneration' model, inflammatory cells infiltrating the prostate release reactive species in response to bacterial/viral infection, uric acid, or dietary prostate carcinogens. Besides inducing inflammation, tissue injury by these and other agents would promote the appearance of proliferative inflammatory atrophy (PIA). A subset of proliferating atrophic cells -possibly showing stemcell features -may be exposed to the genotoxic insult of free radicals and to an increased rate of mutations and chromosomal aberrations, ultimately leading to neoplastic initiation, promotion and progression. In the last decade, the link between inflammation and cancer and the hypothesis pointing to PIA as a risk lesion for prostate cancer have been extensively investigated at the pre-clinical, clinical, morphological, cellular and molecular levels. In this article, recent reports describing supportive or negative evidence on the link between prostate inflammation, atrophy and cancer are schematically reviewed.

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Epidemiologic association between prostatitis and prostate cancer

Cited by 341 publications

References 24 publications

Gonorrhea, Syphilis, Clinical Prostatitis, and the Risk of Prostate Cancer

Gonorrhea, Syphilis, Clinical Prostatitis, and the Risk of Prostate Cancer

Prostate calculi in cancer and BPH in a cohort of Korean men: presence of calculi did not correlate with cancer risk

Inflammation, prostatitis, proliferative inflammatory atrophy: ‘Fertile ground’ for prostate cancer development?

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