Epidemiologic characteristics and clinical course of patients with malignant eyelid tumors in an incidence cohort in Olmsted county, Minnesota

Cook, Briggs E.; Bartley, George B.

doi:10.1016/s0161-6420(99)90161-6

Cited by 296 publications

(247 citation statements)

References 25 publications

Supporting

Mentioning

209

Contrasting

Unclassified

Order By: Relevance

“…This result was the same as that of previous studies. 1,2 The predominance of BCC in the lower eyelid was shown in various studies 2,4,12,13,15 as well as in our study. However, more SGCs occurred in the upper eyelid in various studies 7,8,16,17 and in this study.…”

Section: Sgcsupporting

confidence: 81%

Malignant eyelid tumours in Taiwan

Wang

Liao

Jou

et al. 2003

Eye

View full text Add to dashboard Cite

Aims To describe the clinical characteristics of patients with eyelid cancers in Taiwan. Methods Between 1980 and 2000, 127 (58 males and 69 females) patients (mean age 62.6; range 10-91 years) with histologically confirmed eyelid cancers were retrospectively evaluated at the National Taiwan University Hospital and Far Eastern Memorial Hospital in Taiwan. Clinical data of all patients were reviewed from medical records. The mean follow-up period was 62.4 months (range 3-240) for 113 patients. Results The 127 eyelid cancers included 79 basal cell carcinomas (62.2%), 30 sebaceous gland carcinomas (23.6%), 11 squamous cell carcinomas (8.7%), five malignant melanomas (3.9%), one Kaposi's sarcoma (0.8%), and one metastatic cancer (0.8%). Tumours developed more commonly in the lower (37.0%) than the upper eyelid (33.9%). The clinical accuracy in predicting eyelid malignancy was 90.5%. Primary treatment modality was mainly surgical excision. The recurrence, metastasis, and mortality rates at 5 years were 15.2, 11.7, and 7.3%, respectively, for all eyelid malignancies. Rates of sebaceous gland carcinoma recurrence, metastasis, and mortality were significantly higher (Po0.05) than those of basal cell carcinoma. The mean interval of recurrence or metastasis after primary treatment was 26.3 months (range 4-112) for all eyelid cancers. Conclusions Although basal cell carcinoma is the most common eyelid cancer in Taiwan, sebaceous gland carcinoma is also common. Of the two, basal cell carcinoma has a better prognosis and sebaceous gland carcinoma has a higher mortality and therefore should be treated much more aggressively. Long-term follow-up is needed after treatment of malignant eyelid tumours.

show abstract

Section: Sgcsupporting

confidence: 81%

Malignant eyelid tumours in Taiwan

Wang

Liao

Jou

et al. 2003

Eye

View full text Add to dashboard Cite

show abstract

“…3 The relative incidence of periocular skin malignancies varies with geographical area and racial group. [8][9][10] Basal cell carcinoma is universally the most common malignant skin tumour accounting for approximately 90% in most series; squamous cell and sebaceous gland carcinoma occur in approximately 4-6% each. The incidence of all skin malignancy is increasing worldwide.…”

Section: Indicationsmentioning

confidence: 99%

Orbital exenteration for invasive skin tumours

Tyers

2006

Eye

View full text Add to dashboard Cite

Orbital exenteration aims at local control of disease invading the orbit that is potentially fatal or relentlessly progressive. Of all exenterations presenting to ophthalmologists, 40-50% are required for tumours in the eyelid or periocular skin. 99% of these are basal cell carcinomas and 4-6% each are squamous cell carcinomas or sebaceous gland carcinomas. Orbital invasion results in progressive fixation of the tumour to bone and reduced ocular motility. Perineural invasion of branches of the trigeminal nerve leads to numbness or pain, and that the facial nerve, to weakness. Biopsy identifies the cell type and the presence of perineural invasion. CT and MRI scanning help in the assessment of tumour spread within the orbit. Management should be in collaboration with an oncologist. Exenteration may be totalthe removal of all orbital contents-or lidsparing if the tumour is placed posteriorly. The socket may be allowed to heal by granulation or lined with a split skin graft or local flap. Complications may be seen following 20-25% of exenterations and include fistulae, tissue necrosis, exposed bone, and infection. Incomplete clearance of tumours occurs in about 38% of total exenterations and 17% of subtotal. The overall 5-year survival is 55-65%, but significantly worse if there was perineural spread. Facial prostheses may be mounted on glasses or secured with tissue glue or osseointegrated implants. Excellent cosmetic results can be achieved but many patients prefer to wear a patch.

show abstract

“…Controversy exists as to whether surgery alone, radiotherapy alone, or a combination of surgery with postoperative radiotherapy is the most appropriate treatment for eyelid lesions, particularly when the primary goal is to achieve locoregional control while preserving function and cosmesis. 2,3,9,10 Studies of outcomes to date have included relatively small numbers of patients due to the rarity of the disease. Therefore, the natural history of SCC of the eyelid after treatment requires further clarification.…”

mentioning

confidence: 99%

Outcomes after radiotherapy for squamous cell carcinoma of the eyelid

Petsuksiri

Frank

Garden

et al. 2007

Cancer

View full text Add to dashboard Cite

BACKGROUND. Squamous cell carcinoma (SCC) of the eyelid is a rare malignancy with metastatic potential. In the current study, the outcomes of patients with SCC of the eyelid were evaluated after definitive and postoperative radiation therapy. METHODS. The medical records of all patients treated with radiotherapy for SCC of the eyelid at 1 institution between 1950 and 2005 were reviewed. Patient records were analyzed for clinical characteristics, pathologic features, radiation techniques, and outcomes. Survival rates were calculated using the Kaplan‐Meier method; factors affecting survival were assessed using the log‐rank test. RESULTS. During the study period, 39 patients with 42 eyelid SCCs were treated with radiotherapy. Thirty‐two tumors were treated with primary radiotherapy and 10 were treated with postoperative radiotherapy after wide local excision. Surviving patients were followed for a median of 76 months. The 5‐year disease‐specific and overall survival rates for all patients were 86% and 71%, respectively. At 5 years, local, regional, and distant disease control rates for all tumors were 88%, 95%, and 97%, respectively. There were no significant differences in the 5‐year local, regional, and distant control rates between tumors treated with definitive and those treated with postoperative radiotherapy. There were no grade 3 or 4 complications. CONCLUSIONS. Primary radiotherapy for SCC of the eyelid provides excellent locoregional control with reasonable complication rates and should be considered an alternative to surgery in selected patients. Cancer 2008. © 2007 American Cancer Society.

show abstract

Epidemiologic characteristics and clinical course of patients with malignant eyelid tumors in an incidence cohort in Olmsted county, Minnesota

Cited by 296 publications

References 25 publications

Malignant eyelid tumours in Taiwan

Malignant eyelid tumours in Taiwan

Orbital exenteration for invasive skin tumours

Outcomes after radiotherapy for squamous cell carcinoma of the eyelid

Contact Info

Product

Resources

About