Epidemiologic Characteristics of and Prognostic Factors for COVID-19 Among Hospitalized Patients: Updated Implications From Hubei Province, China

Abstract

Introduction: The roles of some indicators in the prognosis of patients with coronavirus disease-19 (COVID-19) remain unclear and controversial. This study aimed to explore the epidemiologic characteristics of and prognostic factors for COVID-19 to provide updated recommendations for its prevention, diagnosis, and treatment.Methods: For this retrospective study, demographic, epidemiologic, and clinical data were extracted from the medical records of patients admitted to the Maternal and Child Hospital of Hubei Province (Optical Valley) with COVID-19 between February 19, 2020, and March 19, 2020. The primary outcome was the prognosis that was determined at discharge as mentioned in the medical records. Descriptive statistics, univariate analyses, and stepwise logistic regression analysis were used for data analysis.Results: Of the 1,765 patients included, 93.1% were cured and the mortality was 1.8%. Univariate analyses identified 63 factors significantly associated with COVID-19 prognosis. Logistic regression analysis revealed that a poorer prognosis was associated with undergoing resuscitation, complex disease manifestations, consultation with outside specialists, elevated basophil or lymphocyte counts, an albumin (ALB)/globulin (A/G) ratio > 2.4, and elevated levels of serum aspartate aminotransferase (AST) or creatinine. Patients had a better prognosis if the following conditions were met: dry cough reported as an initial symptom, fatigue as a clinical manifestation, and a diagnosis based on laboratory testing.Conclusion: To prevent clinical deterioration, clinicians should provide special care to patients who underwent resuscitation, with a critical disease, or requiring consultation with outside specialists. Extra attention should be paid to patients with high basophil or lymphocyte counts, a high A/G ratio, and elevated AST or creatinine levels.

Minimal Liver Enzymes Abnormalities at Admission Are Related to Severe Covid-19 Clinical Course in a Large Brazilian Cohort

“…In addition, ALE patients had longer hospital stay, as we demonstrated here in agreement some studies (48) . A multicenter retrospective study with 1765 patients in Hubei province, in China, reported an increased mortality risk in cases of elevated AST (above 34 U/L) (49) , although we did not find it, in line with some other studies (43,15) . In the present study, 23.6% of patients died, and patient aged above 60 years had a higher risk of death (40) These findings are consistent with several studies (14,50,51) including a Brazilian one (45) .…”

Age-dependent blood signatures of rehabilitated patients with mild COVID-19

“…Clinical investigations have found that a low level of albumin was associated with a higher risk of COVID-19 infection [21]. Here we observed that the albumin level in rehabilitated patients were dramatically decreased, especially in elderly group.…”

“…Here we observed that the albumin level in rehabilitated patients were dramatically decreased, especially in elderly group. The elevated A/G ratio was reported associated with a poorer prognosis for COVID-19 infection [21]. No signi cant difference in the A/G ratio was observed in rehabilitated patients with mild COVID-19; however, it was signi cant declined when compare the rehabilitated patients with healthy controls in elderlies.…”

Predict In-Hospital Mortality in COVID-19 Patients with a Machine Learning Webpage Tool Based on Clinical Laboratory Data: An Exploratory Research

“…A study in Wuhan, Hubei Province, China, showed that decreased lymphocytes were related to a higher risk of disease severity in male COVID-19 patients with hypertension 38 . However, another study from Hubei province showed that a poorer prognosis was associated with elevated basophil or lymphocyte counts 39 . In our data set, the MO group had increased levels of WBC and neutrophil, lymphocyte, monocyte, eosinophil, and basophil.…”