Epidemiologic characteristics of anotia and microtia in California, 1989–1997

Shaw, Gary M.; Carmichael, Suzan L.; Kaidarova, Zhanna; Harris, John A.

doi:10.1002/bdra.20042

Cited by 118 publications

(169 citation statements)

References 12 publications

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“…The obvious predominance of unilateral cases and among them a slight right side excess in cases with isolated microtia/anotia in our study corresponded to the previous observations in other studies/countries [11,13,15,[18][19][20][21][22][23][24][25].…”

Section: Discussionsupporting

confidence: 92%

“…The mild male excess of cases with isolated ear CAs in the study was in agreement with the results of some previous studies [11,13,15,[18][19][20][21][22][23], though the cases with isolated microtia/anotia in the Italian registry did not show a male predominance [24]. The strong male excess in cases with unclassified multiple ear CA is worth mentioning, because in general previous studies did not have strict differentiation between cases with isolated and multiple ear CAs.…”

Section: Discussionsupporting

confidence: 91%

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Prevalence at birth of congenital abnormalities of external ears in Hungary

Paput¹,

Bánhidy

Czeizel

2011

Open Medicine

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AbstractThe objective of the study was to estimate the prevalence at birth and epidemiologic characteristics of patients/cases with both isolated and multiple “syndromic” external ear congenital abnormalities (CAs) in Hungary. The Hungarian Congenital Abnormality Registry, 1980–1996, included 649 cases with isolated external ear CAs, while the number of cases with unclassified multiple CA, including ear CAs, was 331. Thus the prevalence at birth of cases with isolated external ear CAs and unclassified multiple CAs was 0.30 and 0.15, respectively, for a total 0.46 per 1000 births. After reevaluation of reported 354 cases with isolated external ears CAs in the Hungarian Case-Control Surveillance of Congenital Abnormalities, 74 (20.9%) and 236 (66.7%) were affected with mild and severe microtia, while 24 (6.8%) had anotia. The fourth group included 20 cases with the combination of anotia/microtia and external/middle ear CAs. Isolated ear CAs showed a slight male excess (54.0%) and strong predominance of unilateral manifestation (93.4%). Multiple ear CAs showed a stronger male excess (65.4%) and less frequent unilateral affection (62.2%). In conclusion, ear CAs had a low diagnostic validity; thus it was necessary to reassess the data and to reclassify several cases.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Prevalence at birth of congenital abnormalities of external ears in Hungary

Paput¹,

Bánhidy

Czeizel

2011

Open Medicine

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“…Maternal obesity is also a risk factor for NTDs and other birth defects, possibly due to a similar mechanism [Waller et al, 2007;Stothard et al, 2009]. Some descriptive characteristics of increased NTD risk, such as low maternal education and Hispanic ethnicity, are also seen among infants with microtia [Shaw et al, 2004;Canfield et al, 2009]. Given these epidemiologic similarities between microtia and NTDs, we explored the potential association of microtia with maternal obesity and periconceptional intake of folic-acid-containing supplements.…”

Section: Introductionmentioning

confidence: 96%

“…There is a paucity of epidemiologic information about this condition, and most previous studies have been descriptive. These studies have revealed that risk factors for microtia include advanced maternal age [Harris et al, 1996;Forrester and Merz, 2005;Canfield et al, 2009], male sex [Harris et al, 1996;Shaw et al, 2004;Canfield et al, 2009], low maternal education [Shaw et al, 2004;Husain et al, 2008;Canfield et al, 2009], and Hispanic ethnicity [Harris et al, 1996;Shaw et al, 2004;Forrester and Merz, 2005;Husain et al, 2008;Canfield et al, 2009]. Proposed etiologies include hypoxia [Castilla et al, 1999], in utero exposure to thalidomide [Buyse, 1990;Carey, 1993], maternal influenza [Lopez-Camelo and Orioli, 1996], and maternal diabetes [Mastroiacovo et al, 1995;EwartToland et al, 2000;Correa et al, 2008].…”

Section: Introductionmentioning

confidence: 96%

Association of microtia with maternal obesity and periconceptional folic acid use

Carmichael

Scheuerle

et al. 2010

American J of Med Genetics Pt A

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The study objective was to examine the association of microtia with maternal intake of folic-acid-containing supplements and obesity. The study data included deliveries from 1997 to 2005 from the National Birth Defects Prevention Study. Non-syndromic cases of microtia were compared to non-malformed, population-based liveborn control infants, by estimating adjusted odds ratios (AORs) and 95% confidence intervals (CIs) from logistic regression models that included maternal race/ethnicity, education, and study site. Maternal obesity was only weakly associated with microtia. Maternal periconceptional intake of folic-acid-containing vitamin supplements reduced the risk for microtia, but only among non-obese women (OR: 0.63; 95% CI: 0.44-0.91). The reduced risk was stronger when analyses were restricted to isolated cases (OR: 0.51; 95% CI: 0.34-0.77), and it was independent of the level of maternal dietary folate intake. Adjusting for maternal race/ethnicity did not reveal alternative interpretations of this association. This analysis suggests that maternal periconceptional intake of folic-acid-containing supplements may provide protection from microtia for non-obese women.

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“…Microtia has an incidence of 1 in 7000 to 8000 births in the general population [2,3] . Males are affected more commonly, and the reported ratio of right-to-left-to-bilateral is approximately 5:3:1 with bilateral deformity occurring in only 10% of patients [4,5,6,7].…”

Section: Introductionmentioning

confidence: 99%