Epidemiologic evidence of diabetogenic effect of arsenic

Heavy metals, islet function and diabetes development

“…The incidence of diabetes in these areas (the village exposed to arsenic) was two to five times higher as compared with those in the other non-endemic areas. 42,43 Moreover, similar findings have also been reported in Bangladesh and others. 28,44,45 Recent study has reported that after adjustment for biomarkers of seafood intake, total urine arsenic (median urine level, 7.1 mg/L) is associated with increased prevalence of type 2 diabetes.…”

“…In Taiwan, the areas along the south-western coast were known to have arsenic contamination in drinking wells or underground water and the hyper-endemic occurrence of a peripheral vascular disease (blackfoot disease) in these area's villages. [39][40][41][42][43] In these areas, arsenic concentrations in drinking water were measured and ranged from 0.35 to 1.14 mg/L, with a median of 0.78 mg/L in the early 1960s. 41 Many studies have also indicated that it was a dose-response relationship between accumulative arsenic exposure and prevalence of diabetes mellitus in the villages of the south-western coast of Taiwan exposed to arsenic from drinking water (0.1-15 and >15 mg/L-year).…”

Maternal Arsenic Exposure and Impaired Glucose Tolerance during Pregnancy

“…Accumulating evidence from epidemiologic and experimental studies has shown an increased risk of type 2 diabetes in populations with high exposure to arsenic (Longnecker and Daniels 2001;Navas-Acien et al 2006;Tseng et al 2002). One recent study found an association between arsenic exposure and diabetes in a nationally representative sample of U.S. adults (Navas-Acien et al 2008).…”

Ameliorating Effects of Tomato Puree Against Arsenic Induced Alteration in Ovary of Swiss Albino Mice.

“…Presently, due to enhanced human activities like mining, smelting, coal combustion, etc., the level of arsenic has crossed its permissible limit (Sharma and Singh, 2016) and Chronic intake of arsenic is strongly associated with an increased risk of skin, lung, liver and other cancers, type 2 diabetes, cardiovascular diseases, neurological, cognitive defects, reproductive and developmental problems (Kargas et al, 2002;Prozialerk et al, 2008;Walker et al 2009). But recently arsenic intoxication in experimental animals has been associated with hepatic tumors (Waalkes et al, 2003), inhibition of testicular steroidogenic function (Sarkar et al, 1991) and spermatogenesis (Sukla and Pandey, 1984) as well as with severe metabolic disorders such as diabetes in humans (Longnecker and Daniels, 2001;Tseng et al, 2002). Long term exposure of arsenic is associated with abortion, low birth weight and reduced lactation (Donald et al, 1995) as well as with embryonic cells toxicity in vitro (Lee et al, 1985).…”