Epidemiologic features and clinical presentation of acute Q fever in hospitalized patients: 323 French cases

Dupont, H. Tissot; Raoult, Didier; Brouqui, Philippe; Janbon, F; Peyramond, D.; Weiller, Pierre‐Jean; Chicheportiche, C.; Nezri, Meyer; Poirier, R

doi:10.1016/0002-9343(92)90173-9

Cited by 301 publications

(153 citation statements)

References 13 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…The main significant differences between these two groups are age and sex, with symptomatic patients being significantly older and more often men than asymptomatic or poorly symptomatic patients. This result confirms what has already been described in previous studies: age and sex are the two major determinants of clinical manifestations of C. burnetii primary infection, with older men being more frequently symptomatic than young women, pregnant women and children [2][3][4]. Moreover, the results of Van Loenhout et al confirm that there is no correlation between clinical manifestations of C. burnetii primary infection and the long-term consequences of the infection, with no significant difference in longterm health status between notified and non-notified patients [5].…”

Section: Moving From Q Fever To C Burnetii Infectionsupporting

confidence: 92%

Moving from Q fever to C. burnetii infection

Eldin

Raoult

2015

Epidemiol. Infect.

View full text Add to dashboard Cite

Section: Moving From Q Fever To C Burnetii Infectionsupporting

confidence: 92%

Moving from Q fever to C. burnetii infection

Eldin

Raoult

2015

Epidemiol. Infect.

View full text Add to dashboard Cite

“…Differences in mode of transmission or variations in geographic strain virulence may be responsible for the higher rate of hepatitis observed among military service members. 22,45,46 A higher proportion of reported cases were hospitalized among Hispanics than non-Hispanics. Furthermore, cases among blacks, Asians, and American Indians together were more likely to be hospitalized versus whites alone.…”

Section: Discussionmentioning

confidence: 99%

Q Fever in the United States: Summary of Case Reports from Two National Surveillance Systems, 2000–2012

Dahlgren

McQuiston

Massung

et al. 2015

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Q fever is a worldwide zoonosis historically associated with exposure to infected livestock. This study summarizes cases of Q fever, a notifiable disease in the United States, reported to the Centers for Disease Control and Prevention through two national surveillance systems with onset during 2000-2012. The overall incidence rate during this time was 0.38 cases per million persons per year. The reported case fatality rate was 2.0%, and the reported hospitalization rate was 62%. Most cases (61%) did not report exposure to cattle, goats, or sheep, suggesting that clinicians should consider Q fever even in the absence of livestock exposure. The prevalence of drinking raw milk among reported cases of Q fever (8.4%) was more than twice the national prevalence for the practice. Passive surveillance systems for Q fever are likely impacted by underreporting and underdiagnosis because of the nonspecific presentation of Q fever.

show abstract

“…La Scola et al and Marrie et al demonstrated that the route of infection and the size of the inoculum affected clinical illness and pathology associated with infection in mouse and guinea pig models (26,33). Differences in the geographic distributions of the diseases have also been noted (32); in Nova Scotia, for example, the primary manifestation of acute Q fever is pneumonia (34), but in France it is hepatitis, possibly due to ingestion of raw milk and unpasteurized cheeses (51).…”

mentioning

confidence: 99%

Coxiella burnetiiIsolates Cause Genogroup-Specific Virulence in Mouse and Guinea Pig Models of Acute Q Fever

et al. 2009

View full text Add to dashboard Cite

Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Humans with Q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis. Various markers demonstrate significant phylogenetic separation between and clustering among isolates from acute and chronic human disease. The clinical and pathological responses to infection with phase I C. burnetii isolates from the following four genomic groups were evaluated in immunocompetent and immunocompromised mice and in guinea pig infection models: group I (Nine Mile, African, and Ohio), group IV (Priscilla and P), group V (G and S), and group VI (Dugway). Isolates from all of the groups produced disease in the SCID mouse model, and genogroup-consistent trends were noted in cytokine production in response to infection in the immunocompetent-mouse model. Guinea pigs developed severe acute disease when aerosol challenged with group I isolates, mild to moderate acute disease in response to group V isolates, and no acute disease when infected with group IV and VI isolates. C. burnetii isolates have a range of disease potentials; isolates within the same genomic group cause similar pathological responses, and there is a clear distinction in strain virulence between these genomic groups.

show abstract

Epidemiologic features and clinical presentation of acute Q fever in hospitalized patients: 323 French cases

Cited by 301 publications

References 13 publications

Moving from Q fever to C. burnetii infection

Moving from Q fever to C. burnetii infection

Q Fever in the United States: Summary of Case Reports from Two National Surveillance Systems, 2000–2012

Coxiella burnetiiIsolates Cause Genogroup-Specific Virulence in Mouse and Guinea Pig Models of Acute Q Fever

Contact Info

Product

Resources

About