Epidemiologic History and Genetic Diversity Origins of Chikungunya and Dengue Viruses, Paraguay

Gräf, Tiago; Vázquez, Cynthia; Giovanetti, Marta; Bruycker-Nogueira, Fernanda de; Fonseca, Vagner; Claro, Ingra Morales; Jesus, Jaqueline Góes de; Gómez, Aarón; Xavier, Joilson; Mendonça, Marcos César Lima de; Villalba, Shirley; Torales, Juan; Gamarra, María Liz; Thézé, Julien; Filippis, Ana María Bispo de; Azevedo, Vasco; Oliveira, Túlio de; Franco, Leticia; Albuquerque, Carlos Frederico Campelo de; Irala, Sandra; Holmes, Edward C.; Rico, Jairo Andrés Méndez; Alcântara, Luiz Carlos Júnior

doi:10.3201/eid2705.204244

Cited by 19 publications

(22 citation statements)

References 32 publications

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“…On the American continent, the CHIKV-Asian lineage is widely distributed, while the CHIKV-ECSA lineage is restricted only to Brazil, Paraguay, and Haiti [ 45 , 46 ]. In contrast, in Brazil, the CHIKV-Asian lineage was limited to a small number of cases and was geographically restricted (predominantly in the state of Amapá), whereas the ECSA lineage was widespread [ 20 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Chikungunya Virus Asian Lineage Infection in the Amazon Region Is Maintained by Asiatic and Caribbean-Introduced Variants

Ribeiro

Gill

Ramos

et al. 2022

Viruses

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The simultaneous transmission of two lineages of the chikungunya virus (CHIKV) was discovered after the pathogen’s initial arrival in Brazil. In Oiapoque (Amapá state, north Brazil), the Asian lineage (CHIKV-Asian) was discovered, while in Bahia state, the East-Central-South-African lineage (CHIKV-ECSA) was discovered (northeast Brazil). Since then, the CHIKV-Asian lineage has been restricted to the Amazon region (mostly in the state of Amapá), whereas the ECSA lineage has expanded across the country. Despite the fact that the Asian lineage was already present in the Amazon region, the ECSA lineage brought from the northeast caused a large outbreak in the Amazonian state of Roraima (north Brazil) in 2017. Here, CHIKV spread in the Amazon region was studied by a Zika–Dengue–Chikungunya PCR assay in 824 serum samples collected between 2013 and 2016 from individuals with symptoms of viral infection in the Amapá state. We found 11 samples positive for CHIKV-Asian, and, from these samples, we were able to retrieve 10 full-length viral genomes. A comprehensive phylogenetic study revealed that nine CHIKV sequences came from a local transmission cluster related to Caribbean strains, whereas one sequence was related to sequences from the Philippines. These findings imply that CHIKV spread in different ways in Roraima and Amapá, despite the fact that both states had similar climatic circumstances and mosquito vector frequencies.

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Section: Discussionmentioning

confidence: 99%

Chikungunya Virus Asian Lineage Infection in the Amazon Region Is Maintained by Asiatic and Caribbean-Introduced Variants

Ribeiro

Gill

Ramos

et al. 2022

Viruses

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“…No Peru, ao se avaliar casos de dengue nas regiões Amazônicas e sua relação com a temperatura, demonstrando que o efeito da temperatura sobre a dengue dependeu da estação, com efeitos mais fortes durante as estações chuvosas (CHARETTE et al, 2020). O Paraguai destaca epidemias de dengue, com circulação de diferentes arbovírus, principalmente por fazer fronteira a países como Brasil, sendo considerado um ponto turístico de brasileiros (GRÄF et al, 2021).…”

Section: Saúde E Ambienteunclassified

Dengue, Análise De Tendência E Associação Com Indicadores Socioeconômicos E De Saúde

Andrade

Gaujac²,

Amaral³

2023

ICSA

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Objetivo: Analisar por meio da variação percentual anual (VPA) os números de casos da dengue, a sua tendência temporal e associação com indicadores socioeconômicos e de saúde entre os anos de 2010 a 2021. Métodos: Estudo ecológico em que analisou a tendência temporal dos casos notificados de dengue nos países da América Latina, no período de 2010 a 2021. Os dados de prevalência de casos de dengue foram extraídos do banco da OPAS (Organização Pan-americana de Saúde) e do Instituto Brasileiro de Geografia e Estatística (IBGE). Foram realizadas análises de séries temporais para verificar a VPA e correlação entre as variáveis número de casos, Índice de Desenvolvimento Humano (IDH), incidência de dengue, número confirmados em laboratório, saneamento e índice de pobreza. Resultados: A maior percentual de prevalência de casos de dengue (valor médio dos casos de dengue do período de 2010 a 2021, dividido pelo total da população) no Brasil (0.040% - feminino) e no Paraguai (0.040% - feminino). Não foi encontrado diferença estatisticamente significativa entre sexos (teste Mann Whitney p=0.56). Foram encontradas tendência decrescente nos países Suriname e Venezuela e tendência estacionária no restante dos países analisados. Não foram encontradas correlações estatisticamente significativa entre percentual de casos de dengue e as variáveis sócio econômicas avaliadas. Conclusão: No período analisado a prevalência de dengue se mostrou estacionário na maioria dos países avaliados.

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“…Currently, circulation of ECSA-American lineage has been confirmed in all five geographic regions of Brazil [15][16][17][18][19][20], but also in Paraguay [21] and Haiti [22]. Rio de Janeiro (RJ) is the third most populous Brazilian state and a key business and touristic hub in the Americas.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and genomic investigation of chikungunya virus in Rio de Janeiro state, Brazil, between 2015 and 2018

Moreira

Menezes

Salgado-Benvindo

et al. 2023

Preprint

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Since 2014, Brazil has experienced an unprecedented epidemic caused by chikungunya virus (CHIKV), with several waves of East-Central-South-African (ECSA) lineage transmission reported across the country. In 2018, Rio de Janeiro state, the third most populous state in Brazil, reported 41% of all chikungunya cases in the country. Here we use evolutionary and epidemiological analysis to estimate the timescale of CHIKV-ECSA-American lineage and its epidemiological patterns in Rio de Janeiro. We show that the CHIKV-ECSA outbreak in Rio de Janeiro derived from two distinct clades introduced from the Northeast region in mid-2015 (clade RJ1, n = 63/67 genomes from Rio de Janeiro) and mid-2017 (clade RJ2, n = 4/67). We detected evidence for positive selection in non-structural proteins linked with viral replication in the RJ1 clade (clade-defining: nsP4-A481D) and the RJ2 clade (nsP1-D351G). Finally, we estimate the CHIKV-ECSA's basic reproduction number (R0) to be between 1.2 to 1.6 and show that its instantaneous reproduction number (Rt) displays a strong seasonal pattern with peaks in transmission coinciding with periods of high Aedes aegypti transmission potential. Our results highlight the need for continued genomic and epidemiological surveillance of CHIKV in Brazil, particularly during periods of high ecological suitability, and show that selective pressures underline the emergence and evolution of the large urban CHIKV-ECSA outbreak in Rio de Janeiro.

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Epidemiologic History and Genetic Diversity Origins of Chikungunya and Dengue Viruses, Paraguay

Cited by 19 publications

References 32 publications

Chikungunya Virus Asian Lineage Infection in the Amazon Region Is Maintained by Asiatic and Caribbean-Introduced Variants

Chikungunya Virus Asian Lineage Infection in the Amazon Region Is Maintained by Asiatic and Caribbean-Introduced Variants

Dengue, Análise De Tendência E Associação Com Indicadores Socioeconômicos E De Saúde

Epidemiological and genomic investigation of chikungunya virus in Rio de Janeiro state, Brazil, between 2015 and 2018

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