Epidemiologic investigation of amyotrophic lateral sclerosis in Trakya, Turkey, 2006-2010

Turgut, Nilda; Saraçoğlu, Gamze Varol; Kat, Selahattin; Balcı, Kemal; Birgili, Özlem; Kabayel, Levent; Yagıbasan, S.; Ersöz, Elif Köksal; Kor, L.; Küçük, Mert

doi:10.1016/j.jns.2015.08.729

Cited by 1 publication

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“…In studies conducted in Turkey, these rates are 60% and 75.6% for clinically definite ALS, and it was determined as 24.8% and 11% for clinically probable ALS (8,9). 45.2% of our patients were in the clinically definite ALS group, and 35.7% were in the clinically probable ALS group.…”

Section: Discussionmentioning

confidence: 57%

“…It is known that male gender is a risk factor for ALS.6 Male / female (M/F) rate in ALS patients varies between 1-3 in many studies (6)(7)(8)(9)(10)(11). In studies conducted in Antalya province and Thrace region in Turkey, this rate was found as 1.78 and 2 (8,9).…”

Section: Discussionmentioning

confidence: 99%

“…The mean age of onset of ALS has been reported as 56 and 60, respectively, in Russia and Greece, Turkey's northern and western neighbors (10,11). The mean age of onset of ALS in Turkey was reported as 56 and 58 in two different studies conducted in the western regions of Turkey (8,9). In our study, the mean age of onset of ALS patients was found to be 53.4±12.3, and this value showed that the mean age of onset of ALS in our patients was lower when compared to the results of two other studies conducted in Turkey.…”

Section: Discussionmentioning

confidence: 99%

“…The mean delay between the onset of ALS symptoms and diagnosis was 13.6±10.9 months. This period is specified between 9-24 months in many studies (8,(15)(16)(17). Results regarding the distribution of onset symptoms have been reported to be contradictory in different studies.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and epidemiological features of amyotrophic lateral sclerosis in eastern Turkey

Yevgi

Bilge

2021

Journal of Health Sciences and Medicine

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Aim:The number of studies on the epidemiological and clinical data of amyotrophic lateral sclerosis (ALS) patients in Turkey is quite low and the studies on this subject reflect the data of western regions of Turkey. In this study, we aimed to present the demographic, clinical and mortality features of ALS patients diagnosed in the last 10 years in a large reference hospital in the Eastern Anatolia region of Turkey. Material and Method: 42 ALS patients diagnosed between January 2011 and January 2021 in Atatürk University, Faculty of Medicine, Department of Neurology were included in the study. The data of the patients were obtained by retrospectively scanning the patient electronic files registered in the database of our hospital. The age, gender, examination findings, clinical course, treatments they received and the cause of death of the patients were recorded. Results: 26 of ALS patients were men and 16 were women. The mean age of onset was 53.4±12.3 and the mean diagnostic delay was 13.6±6.9 months. 64.2% of the patients had onset in the spinal region, and 35.7% in the bulbar region. Weakness/atrophy of the upper extremity muscles and swallowing difficulty were the most common onset symptoms. All ALS patients were using riluzole. 11 ALS patients died. The mean time between diagnosis and death in patients who died was 27.2±18.6 months. The most common causes of death in ALS patients were pneumonia and sepsis. Conclusion: Age of onset of ALS was low in our patients. The number of patients in the clinically definite ALS group was the highest. Weakness/atrophy of the upper extremity muscles and swallowing difficulty were the most common onset symptoms. Approximately 2/3 of the patients had spinal, and 1/3 bulbar region onset. There was no significant difference between spinal and bulbar onset patients in terms of gender, age of disease onset, mortality, and life expectancy of patients with death. The rate of using riluzole was high. The most common causes of death in ALS patients were pneumonia and sepsis.

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Section: Discussionmentioning

confidence: 57%