Epidemiologic, microbiologic and imaging characteristics of urinary tract infections in hospitalized children &lt; 2 years of age diagnosed with anatomic abnormalities of the urinary tract

Landau, Zohar; Cherniavsky, Evgenia; Abofreha, Salman; Linder, Ilan; Leibovitz, Ron; Roif-Kaminsky, Diana; Friger, Michael; Bilenko, Natalya; Leibovitz, Eugene

doi:10.1016/j.pedneo.2022.01.005

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…On the other hand, data from Turkey and the United States are not as alarming as those obtained in our study (0.5-17%) [24][25][26]. Israeli research showed that in children with CAKUT among Escherichia coli and Klebsiella pneumoniae isolates ESBL(+) strains reached 8.9% and 22% respectively, but, interestingly, it was not different from children without CAKUT [18]. However, it should be noted that some of these results were based on analyses conducted in children with UTI who were treated on an outpatient basis.…”

Section: Discussioncontrasting

confidence: 65%

“…Landau et al reported that in children with CAKUT resistance rates of Escherichia coli to ampicillin, amoxicillin/clavulanic acid, cefuroxime, trimethoprim-sulfamethoxazole and ceftriaxone were 58%, 40%, 14%, 12%, 10% respectively [18]. Also Rosado et al revealed an increase in resistance of Escherichia coli to amoxicillin/clavulanate (from 12.2% to 24% in the last 10 years) [19].…”

Section: Discussionmentioning

confidence: 98%

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Analysis of bacterial flora of urinary tract infection in hospitalized children with and without congenital urinary tract malformations

Seraficka,

Stańczyk,

Tkaczyk

2023

polp

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Introduction:The purpose of this study was to determine the relationship between the composition and drug susceptibility of the bacterial flora of urinary tract infections (UTI) and the presence of a congenital urinary tract malformation in children. Material and methods:The study included analysis of 515 urine cultures obtained from patients hospitalized at a tertiary referral hospital over a 24-month period. Drug susceptibility of Escherichia coli strains, which are the leading uropathogen in UTI, to antibiotics of the group comprising penicillins, carbapenems, aminoglycosides, fluoroquinolones, and nitrofurantoin and trimethoprim-sulfamethoxazole was determined using the automated Vitek 2 Compact method, the plate-diffusion method and E-tests. The abundance of strains producing an extended-spectrum β-lactamase (ESBL) type resistance mechanism was also analyzed. Results:The distribution of cases for Escherichia coli (n = 228) was comparable (p = 0.134) for patients with (40.10%) and without urinary tract defects (46.86%). Comparing the numbers of etiological agents in this group of patients, statistically significant differences were found for infections caused by yeast-like fungi -Candida spp. (p = 0.011) and Pseudomonas aeruginosa (p = 0.002). In terms of Escherichia coli antibiotic resistance, statistically significant differences in their effectiveness were observed for all cephalosporins analyzed, as well as for nitrofurantoin. No such effect was noted for other antibiotics. An extended-spectrum β-lactamase type resistance mechanism was present in Escherichia coli strains isolated from patients with a urinary tract defect -10.13% of cases, vs. only 2.01% of cases for patients without a malformation (p = 0.016). Conclusions:The study showed that the presence of congenital anomalies of the kidney and urinary tract (CAKUT) in children predisposes to Pseudomonas aeruginosa infections, but does not affect the frequency of isolation of Escherichia coli or other strains of bacteria causing urinary tract infections. The presence of CAKUT increases the risk of infection with bacteria with lower sensitivity to the most commonly used first-line antibiotics. Moreover, it increases the risk of Escherichia coli strains with β-lactamase-producing extended substrate spectrum (ESBL+).

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 98%

Analysis of bacterial flora of urinary tract infection in hospitalized children with and without congenital urinary tract malformations

Seraficka,

Stańczyk,

Tkaczyk

2023

polp

View full text Add to dashboard Cite

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Diagnosis and Antibiotic Resistance of Enterococcus Spp. Causing Urinary Tract Infections in Children

Dănăilă,

Ungureanu,

Petcu

2022

Roum Arch Microbiol Immunol

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Introduction: Among Gram-positive bacteria, enterococci are considered the most frequent pathogens in the case of urinary tract infections (UTIs) in children. It is known that enterococci have intrinsic resistance and acquired resistance is achieved by different mechanisms for: beta-lactams, aminoglycosides, quinolones, glycopeptides and linezolid. Objectives: The purpose of this review is to demonstrate that Enterococcus spp. is a frequent cause of urinary infections in children and to analyze antibiotic resistance. Materials and methods: The research was conducted using specific keywords such as “antibiotic resistance”, “children”, “UTI”, “Enterococcus spp.”, and “biofilm”, in specialty books, Google Scholar, PubMed, ScienceDirect and PubMed Central (PMC). Results: Antibiotic resistance of Enterococcus spp. is an issue in the choice of treatment for urinary tract infections. According to certain research, resistance to vancomycin has increased in some countries while decreasing in others. Another concerning problem is the observed gentamicin resistance, notably in Enterococcus faecium. Discussion: Virulence factors, particularly Esp, which is involved in biofilm formation, play a key role in the processes of antibiotic resistance development. The presence of vanA and vanB genes modifies the structure of the bacteria and leads to the emergence of antibiotic resistance. Enterococcal resistance to vancomycin (VRE) represents a major public health problem and is the main mechanism that occurs in nosocomial infections. Conclusions: Enterococcus spp. is one of the most prevalent etiological agents in urinary pathology and a common source of nosocomial infections. Because of the presence of virulence factors and genes, these bacteria can easily acquire resistance to specific antibiotics. Keywords: antibiotic resistance, children, UTI, Enterococcus spp., biofilm

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Epidemiologic, microbiologic and imaging characteristics of urinary tract infections in hospitalized children < 2 years of age diagnosed with anatomic abnormalities of the urinary tract

Cited by 2 publications

References 29 publications

Analysis of bacterial flora of urinary tract infection in hospitalized children with and without congenital urinary tract malformations

Analysis of bacterial flora of urinary tract infection in hospitalized children with and without congenital urinary tract malformations

Diagnosis and Antibiotic Resistance of Enterococcus Spp. Causing Urinary Tract Infections in Children

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