Epidemiologic pattern of patients with neurocysticercosis diagnosed by computed tomography in Curitiba, Brazil

Grazziotin, Ana Laura; Fontalvo, Mariana Campos; Santos, Marilis Beckert Feijó; Monego, Fernanda; Grazziotin, Ana Line; Kolinski, Victor Hugo Zanini; Bordignon, Rodrigo Henrique; Biondo, Alexander Welker; Antoniuk, Affonso

doi:10.1590/s0004-282x2010000200022

Cited by 9 publications

(4 citation statements)

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“…The relationship between sex and NCC infection risk is controversial. Some studies showed a higher frequency of the disease in males (Chimelli et al, 1998;Chagas et al, 2003;Lino-Junior et al, 2007;Almeida and Torres, 2011), while others showed a higher prevalence of NCC in females (Pfuetzenreiter and Avila-Pires, 1999;Mendes et al, 2005;Benedeti et al, 2007;Grazziotin et al, 2010;Coral-Almeida et al, 2015). A previous literature review on NCC epidemiology in Brazil showed a higher prevalence of NCC among males, with more frequent involvement of severe manifestations in female patients (Agapejev, 2003(Agapejev, , 2011.…”

Section: Discussionmentioning

confidence: 99%

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Neurocysticercosis-related mortality in Brazil, 2000–2011: Epidemiology of a neglected neurologic cause of death

et al. 2016

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Neurocysticercosis (NCC) is an important cause of severe neurological disease mainly in low- and middle-income countries, but data on NCC mortality from endemic areas are scarce. Here we analysed the epidemiological patterns of NCC-related mortality in Brazil. We included all deaths recorded in Brazil between 2000 and 2011, in which NCC was mentioned on death certificates, either as underlying or as associated cause of death. NCC was identified in 1829/12,491,280 deaths (0.015%), 1130 (61.8%) as underlying cause, and 699 (38.2%) as associated cause. Overall age-adjusted mortality rate for the period was 0.97 deaths/1,000,000 inhabitants (95% confidence interval [CI]: 0.83-1.12). The highest NCC-related mortality rates were found in males, elderly, white race/colour and residents in endemic states/regions. Age-adjusted mortality rates at national level decreased significantly over time (annual percent change [APC]: -4.7; 95% CI: -6.0 to -3.3), with a decrease in the Southeast, South and Central-West regions, and a non-significant increasing trend in the North and Northeast regions. We identified spatial and spatiotemporal high-risk mortality clusters located mainly in NCC-endemic areas. Conditions related to the nervous system were the most commonly associated causes of death when NCC was mentioned as an underlying cause, and HIV/AIDS was the main underlying cause when NCC was an associated cause. NCC is a neglected and preventable cause of severe neurologic disease and death with high public health impact in Brazil. There is a clear need to strengthen nationwide epidemiological surveillance and control for the taeniasis/cysticercosis complex.

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Section: Discussionmentioning

confidence: 99%

“…Gender-specific healthcare seeking behaviour may also play a role. The more frequent occurrence of clinical manifestations in women would lead them to seek medical assistance more frequently and, consequently, to carry out more diagnostic testing than men (Pfuetzenreiter and Avila-Pires, 1999;Grazziotin et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Neurocysticercosis-related mortality in Brazil, 2000–2011: Epidemiology of a neglected neurologic cause of death

et al. 2016

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“…To determine whether a tumor is primary or not, and the primary site of metastatic tumors, immunohistochemical analysis can be used, with specific markers for each tissue and cell. 6 The use of multiple markers may increase the sensitivity, specificity and positive predictive value in predicting the tissue of tumor origin. 13 …”

Section: Discussionmentioning

confidence: 99%

“…The costs due to neurocysticercosis treatment and complications in Brazil may reach up to US$ 85 million. 6 …”

Section: Introductionmentioning

confidence: 99%

Cystic brain metastases radiologically simulating neurocysticercosis

et al. 2011

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CONTEXT: Brain metastases are common complications of cancer. Magnetic resonance imaging (MRI), the main diagnostic imaging method in these cases, rarely shows cystic images. CASE REPORT: The patient was a 45-year-old woman who had had severe headache for a month that was refractory to medication, and had previously had breast cancer, which had been treated. The MRI showed the criteria for neurocysticercosis. Since there was no improvement with clinical treatment, we chose to excise the lesions. Histopathological analysis showed an epithelioid malignant neoplasm. CONCLUSION: From immunohistochemical analysis, it was concluded that this was a metastasis of breast carcinoma. Even when the MRI is not characteristic of cerebral metastasis, this hypothesis needs to be ruled out in patients with a previous history of cancer.resUMo CONTEXTO: Metástases cerebrais são complicações comuns do câncer. A ressonância nuclear magnética (RNM), principal método de diagnóstico por imagem nesses casos, mostra raramente imagens císticas. RELATO DO CASO: A paciente era uma mulher de 45 anos de idade, com cefaleia intensa há um mês, refratária à medicação, e câncer de mama tratado previamente. A RNM apresentava critérios diagnósticos para neurocisticercose. Como não apresentou melhora com tratamento clínico, optou-se pela exérese das lesões. O histopatológico mostrou neoplasia maligna epitelioide. CONCLUSÃO: A imunoistoquímica revelou metástase de carcinoma da mama. Mesmo quando a RNM não é característica de metástase cerebral, esta hipótese precisa ser afastada em pacientes com história prévia de câncer.

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Neurocysticercosis—Retrospective Study of Autopsy Reports, a 17-Year Experience

Almeida

Torres

2011

J Community Health

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Neurocysticercosis (NCC) is a common central nervous system (CNS) infection caused by Taenia solium metacestodes. The objective of this study is to describe the incidence of cysticercosis diagnosed at autopsies and describe the epidemiological and clinical characteristics of NCC. Retrospective study analyzing 6,500 reports of autopsies between 1977 and 1994 from a school hospital in Curitiba, PR, southern of Brazil. The following data was obtained, age, gender, site of cysticercosis, NCC as cause of death. The diagnosis of cysticercosis was established in 52 (0.8%) autopsies. From 1977 to 1987 (0.7%) and from 1988 to 1994 (1.1%). In the autopsies with cysticercosis 75% were male; age (mean ± SD) was 43 ± 20. NCC was present in 96% of cases, and seizures was the most frequent clinical manifestation. Asymptomatic cases in 54%. These data classify our area as hiperendemic, according with OMS criteria. The present study reinforces the necessity to develop adequate control programs.

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Epidemiologic pattern of patients with neurocysticercosis diagnosed by computed tomography in Curitiba, Brazil

Cited by 9 publications

References 9 publications

Neurocysticercosis-related mortality in Brazil, 2000–2011: Epidemiology of a neglected neurologic cause of death

Neurocysticercosis-related mortality in Brazil, 2000–2011: Epidemiology of a neglected neurologic cause of death

Cystic brain metastases radiologically simulating neurocysticercosis

Neurocysticercosis—Retrospective Study of Autopsy Reports, a 17-Year Experience

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