Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: Demographic, physical, dietary and biochemical characteristics

Kagan, Abraham; Harris, B. R.; Winkelstein, Warren; Johnson, Kenneth G.; Kato, Hiroo; Syme, S. Leonard; Rhoads, George G.; Nichaman, Milton Z.; Hamilton, Howard B.; Tillotson, J

doi:10.1016/0021-9681(74)90014-9

Cited by 510 publications

(215 citation statements)

References 35 publications

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“…The findings suggest some effect in the environment or in the lifestyle of Japanese-Americans acting protectively against stroke. There is, for example, a significant difference in fat and protein intakes as well as in serum cholesterol levels between indigenous and migrant Japanese populations 15 while no substantial difference is found in blood pressure between the 2 populations. Our findings are consistent with the position of Kimura 1 ' that " .…”

Section: Discussionmentioning

confidence: 94%

Factors related to stroke incidence in Hawaii Japanese men. The Honolulu Heart Study.

Kagan¹,

Popper²,

Rhoads³

1980

Stroke

204

100

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SUMMARY As part of an ongoing longitudinal study of coronary heart disease and stroke among Japanese men in Hawaii, 8,006 men of Japanese ancestry living on the island of Oahu and aged 45-68 at entry examination have been followed by reexamination and surveillance. One hundred and eleven were found to have evidence of prior stroke at the time of the initial examination. During a six-year follow up period of the remaining 7,895 men, 94 developed definite thromboembolic stroke, 33 definite intracranial hemorrhage, and 6 developed stroke of unknown type. The principal risk factors for thromboembolic stroke were: elevated blood pressure, glucose intolerance, age, and electrocardiographic evidence of left ventricular hypertrophy or strain. Attributes associated with increased risk of intracranial hemorrhage were elevated blood pressure, electrocardiographic evidence of left ventricular hypertrophy or strain, and alcohol intake. Serum cholesterol level was negatively associated with risk of intracranial hemorrhage.

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Section: Discussionmentioning

confidence: 94%

Factors related to stroke incidence in Hawaii Japanese men. The Honolulu Heart Study.

Kagan¹,

Popper²,

Rhoads³

1980

Stroke

204

100

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“…14 The presence of CHD was established by clinical history and electrocardiogram 15 while stroke was diagnosed by history and physical examination. 16 Men judged free of these conditions have been followed to the tenth anniversary of their baseline examination for the incidence of disease.…”

Section: Methodsmentioning

confidence: 99%

Serum triglyceride and risk of coronary heart disease, stroke, and total mortality in Japanese-American men.

Rhoads

Feinleib

1983

Arteriosclerosis

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The role of serum triglyceride as a risk factor for coronary heart disease (CHD), stroke, and total mortality was examined in men of Japanese ancestry who were 45 to 78 years old. During the first 10 years following a baseline nonfasting triglyceride determination, there were 490 incidence cases of CHD in 7615 men at risk. Average annual incidence rates were 2.1 times higher in men with nonfasting values above the 75th percentile (279 mg/dl) than in those under the 25th percentile (129 mg/dl, p < 0.001). This association largely disappeared when associations of triglyceride with other CHD risk factors were accounted for.Fasting triglycerides were measured in a representative sample of 1729 men partway through the study. With an average follow-up of 5.7 years there were 72 new CHD cases in this group with the risk for men in the top quartile (above 195 mg/dl) being 1.9 times higher than for those in the bottom quartile (below 94 mg/dl). This gradient was of borderline significance (p < 0.10) and completely disappeared in a multivariate analysis which included HDL and other factors. It appears that the association of triglyceride with CHD in this cohort is of a noncausal nature. Triglycerides were not predictive of stroke or of total mortality in these men. (Arteriosclerosis 3:316-322, July/August 1983) E arly case-control studies identified serum triglyceride as a potential risk factor for coronary heart disease (CHD). 1 " 4 Since it was a major constituent of the lipoproteins and was found in atherosclerotic plaque, 5 there was reason to suspect that these findings had causal implications, and primary hypertriglyceridemia has subsequently received considerable attention.Over the past two decades a number of prospective studies have focused on the role of triglycerides as risk factors. 6 " 12 In most of these, triglycerides were positively related to CHD, but in multivariate logistic regressions the associations appeared to be explained by other variables, especially age, obesity, high density lipoprotein (HDL) and low density lipoprotein (LDL). The implication is that hypertriglyceridemic persons tend to have other characteristics which put them at risk for CHD, but that the triglycerides per se have little effect on risk. Thus, Hulley et al. 13 recommended "that widespread screening and treatment of healthy persons for hypertriglyceridemia be abandoned." In this paper we present further epidemiological evidence on the association of triglycerides with atherosclerotic diseases based on a large data set collected prospectively among Japanese-American men in Honolulu. Attention is focused on comparative findings for fasting and nonfasting triglycerides and on the effect of reproducibility of measurement in interpreting the results.

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“…Risk factors for ischemic stroke included in our clinical protocol were: 1) age, sex, race/ethnicity; 2) history of hypertension; 3) current smoking; 4) history of cardiac disease (atrial fibrillation or coronary artery disease, defined as previous myocardial infarction, angina or a coronary revascularization procedure); 5) history of diabetes mellitus (DM); 6) hypercholesterolemia; 7) history of ischemic stroke or TIA 16 . Specimens Serum specimens were centrifuged and frozen within 2 hours of collection and stored at -70ºC until the aPL enzyme-linked immunoabsorbant assays (ELISA) were performed with standardized kits.…”

Section: Subjectsmentioning

confidence: 99%

Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia

Staub

Norman

Crowther

et al. 2003

Arq. Neuro-Psiquiatr.

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-One third of cases of cerebral ischemia have no clear etiology. A humoral response to the atherosclerotic plaques components beta2-glycoprotein I (beta2-gpI) and heat-shock proteins (Hsp) might be involved in the pathogenesis of stroke. This case-control study includes a complete profile of anti-beta2-gpI antibodies and testing of IgG antibodies to the 60/65 kilodaltons (kDa) Hsp in stroke patients. Ninety-three patients with acute ischemic stroke and 93 controls were evaluated for age, sex, race, hypertension, smoking, previous cardiopathy, diabetes mellitus, hypercholesterolemia and previous history of cerebral ischemia. IgG/ IgM/IgA anticardiolipin (aCL) and anti-beta2-gpI antibodies, as well as IgG antibodies to human 60 kDa Hsp and to Mycobacterium bovis 65 kDa Hsp, were detected by immunoassay. Adjusted odds ratios (OR) were calculated by logistic regression. The adjusted OR for IgA anti-beta2-gpI antibodies was 4.6 (90%CI 1.5 to 14.3; p = 0.025). The non-adjusted OR for IgG antibodies to Hsp 60 was 26.1. The adjusted OR for IgG antibodies to Hsp 65 was 3.2 (90%CI 1.2 to 8.3; p = 0.044). The adjusted OR for IgG to any Hsp (60 or 65) was 4.8 (90%CI 1.9 to 12.1; p = 0.006). This study demonstrates that elevated IgA anti-beta2-gpI and IgG antiHsp 60/65 antibodies are associated with increased risk of ischemic stroke. The association occurred independently of other risk factors. This humoral response might link autoimmunity, thrombophilia and atherosclerosis in stroke patients.KEY WORDS: anti-beta2-gpI antibodies, anti-Hsp 60/65 antibodies, acute cerebral ischemia.Anticorpos contra os componentes da placa aterosclerótica beta2-glicoproteína I e proteínas de choque Anticorpos contra os componentes da placa aterosclerótica beta2-glicoproteína I e proteínas de choque Anticorpos contra os componentes da placa aterosclerótica beta2-glicoproteína I e proteínas de choque Anticorpos contra os componentes da placa aterosclerótica beta2-glicoproteína I e proteínas de choque Anticorpos contra os componentes da placa aterosclerótica beta2-glicoproteína I e proteínas de choque térmico como fatores de risco para isquemia cerebral aguda térmico como fatores de risco para isquemia cerebral aguda térmico como fatores de risco para isquemia cerebral aguda térmico como fatores de risco para isquemia cerebral aguda térmico como fatores de risco para isquemia cerebral aguda RESUMO -Um terço dos casos de isquemia cerebral não apresenta etiologia clara. Uma resposta humoral contra os componentes da placa aterosclerótica beta2-glicoproteína I (beta2-gpI) e proteínas de choque térmico ("heat-shock proteins", Hsp) pode estar envolvida na patogênese do infarto cerebral. Este estudo de caso-controles inclui um perfil completo de anticorpos anti-beta2-gpI e a testagem de IgG anti-Hsp de 60/65 kilodaltons (kDa) em pacientes com isquemia cerebral. Noventa e três pacientes com isquemia cerebral aguda e 93 controles foram avaliados quanto a idade, sexo, raça, hipertensão arterial, tabagismo, cardiopatia prévia, diabete mellitus, hip...

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Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: Demographic, physical, dietary and biochemical characteristics

Cited by 510 publications

References 35 publications

Factors related to stroke incidence in Hawaii Japanese men. The Honolulu Heart Study.

Factors related to stroke incidence in Hawaii Japanese men. The Honolulu Heart Study.

Serum triglyceride and risk of coronary heart disease, stroke, and total mortality in Japanese-American men.

Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia

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