Epidemiologic Studies of Diabetes in the Pima Indians

Bennett, Peter H.; Rushforth, Norman B.; Miller, Max; LeCompte, Philip M.

doi:10.1016/b978-0-12-571132-6.50021-x

Cited by 103 publications

(78 citation statements)

References 40 publications

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“…The highest diabetes prevalence rates reported in the literature (approximately 35%) are in the American Pima Indians [1] and in the Micronesian population of Nauru [2]. Prevalence rates are also quite high in a number of other American Indian populations [10,25,26], other Pacific island populations -Western Samoa [14], Tonga [27], Australian aboriginals [28], Fiji Indians [30] , certain groups in Papua New Guinea [29], and other migrant Indian communities in Singapore [22], Malaysia [31] and South Africa [32], and in the Maltese population [33].…”

Section: Prevalence Of Type 2 Diabetesmentioning

confidence: 90%

“…Hyperinsulinaemia is well documented in a number of populations which now exhibit high Type 2 diabetes prevalence rates. These include the Pima Indians [1], Nauruans [65] and Australian aborigines [66]. Thus, 'down regulation' of the insulin receptor in the face of persistent hyperinsulinaemia may create a vicious circle whereby the B cells eventually fail in the face of loss of insulin sensitivity and the production of insulin resistance.…”

Section: Genetic Factorsmentioning

confidence: 99%

“…Although the thought of epidemiology has always produced a yawn as far as apparent interest is concerned, natural phenomena such as the Pima [1] and Nauru [2,3] situations should really be called a 'diabetologist's delight'. Nature itself provides a number of experimental situations for the study of diabetes all over the globe.…”

mentioning

confidence: 99%

“…The epidemiology thrust has gathered momentum as diabetologists turn to these studies to gain further understanding of aetiological mechanisms, and of the natural history of diabetes and its complications. Perhaps the best known example is the Pima Indian study -a systematic longitudinal study that has continued to provide a wealth of information about Type 2 (noninsulin-dependent) diabetes [1].…”

mentioning

confidence: 99%

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Type 2 (non-insulin-dependent) diabetes ? An epidemiological overview

1982

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Summary.Despite the use of a wide range of different methodologies and diagnostic criteria, epidemiological studies have shown that Type 2 (non-insulindependent) diabetes has a global distribution and its prevalence varies from country to country, in different ethnic groups in the same country, and between the same ethnic group undergoing internal or external migration. Rural-urban and migration studies indicate that change towards a 'Westernized' lifestyle is associated with a dramatic increase in the prevalence rates for Type 2 diabetes. Between populations, comparisons are confounded by a wide range of different ascertainment rates, survey methodologies, and diagnostic criteria for diabetes. However, low prevalence rates for Type 2 diabetes are seen in Eskimos and populations of the Far East, while the highest are seen in American Indians, urbanized Pacific Island populations, and migrant Asian Indians. Available evidence suggests that these latter groups have a genetic susceptibility to Type 2 diabetes ('diabetes genotype') and that the disease is unmasked by environmental factors. There appears to be a spectrum of interaction between genetic and environmental factors -in certain populations the genetic role may be more important than environmental, or vice versa. Epidemiological studies, apart from their value in population screenings and case-finding, have contributed to the new classification and diagnostic criteria for diabetes and our understanding of risk factors and host characteristics in the aetiology of Type 2 diabetes.

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Section: Prevalence Of Type 2 Diabetesmentioning

confidence: 90%

Section: Genetic Factorsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Type 2 (non-insulin-dependent) diabetes ? An epidemiological overview

1982

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“…By whatever criteria they use, physicians are seldom wrong in making the diagnosis of diabetes, although, obviously many cases will remain undiagnosed unless looked for. 4 Finally, environmental and dietary factors do not preclude the importance of heredity in the etiology of diabetes. Incredible as it may seem, diabetes was unknown among Native Americans until this century, yet today it is one of their leading causes of morbidity and mortality.…”

mentioning

confidence: 99%