Epidemiologic studies of oral mucosal conditions – methodologic issues

Kleinman, Dushanka V.; Swango, Philip A.; Niessen, Linda C.

doi:10.1111/j.1600-0528.1991.tb00128.x

Cited by 71 publications

(66 citation statements)

References 82 publications

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“…13,19 Opportunistic case finding is already an important component of a routine dental check-up, but further research is needed to determine the prevalence in the general population as well as in different subpopulations and ethnic groups, so that appropriate high risk groups can be targeted. 52,53 The results of this study suggest that the population attending general dental practices, who are self selecting and therefore thought to be not representative, is representative of the general population both in terms of lesion prevalence and high risk habits. This suggests that opportunistic screening in a general dental practice setting may be a realistic option.…”

Section: Discussionmentioning

confidence: 96%

Opportunistic screening for oral cancer and precancer in general dental practice: results of a demonstration study

et al. 2003

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Section: Discussionmentioning

confidence: 96%

Opportunistic screening for oral cancer and precancer in general dental practice: results of a demonstration study

et al. 2003

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“…The incidence and prevalence of oral leukoplakia in the UK are not known. However, outside the UK, the prevalence has been estimated to range from 0.2 to 11.7% [56]. The variation in prevalence between studies is likely to be due to varying methodology as well as population dierences in risk factor prevalence.…”

Section: Precancerous Lesions/conditions and Malignant Transformationmentioning

confidence: 99%

Oral cancer in the UK: to screen or not to screen

1998

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Although oral squamous cell carcinoma accounts for only a small proportion of malignant neoplasms in the UK, oral cancer incidence and mortality rates have been rising in recent years. The natural history of oral cancer is not adequately understood at present and there is very little information about the epidemiology of precancerous lesions in the UK. There are also insucient data to provide ®rm evidence that the percentage of cases arising de novo is greater in the UK and the Western world as compared to the Indian subcontinent. Screening for oral cancer by visual examination is simple, inexpensive and causes little discomfort; however, there is no evidence for the eectiveness of screening for oral cancer either in reducing mortality from the disease or in reducing the incidence of invasive disease by detection and treatment of precancerous lesions. There is currently insucient evidence to recommend population screening for oral cancer in the UK. Measures aimed at primary prevention of the disease may be a more feasible method of disease control at present. #

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“…The discovery of insulin treatment justified a close correlation between the disorder of the carbohydrate metabolism and oral inflammatory complications (4). The adequate treatment of diabetes results in marked improvement of the gingival and periodontal lesions.…”

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confidence: 99%

Diabetes and Oral Tumors in Hungary

et al. 2004

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OBJECTIVE -Numerous publications have already demonstrated that diabetes is a risk factor for the development of periodontal diseases and various inflammatory lesions in the oral mucosa. A possible correlation between diabetes and oral premalignancies and tumors was examined in this study, as no literature data are available concerning this problem.RESEARCH DESIGN AND METHODS -Stomato-oncological screening was carried out on 200 diabetic patients in the medical departments; the control group included 280 adult dentistry outpatients. The lesions found were classified into three groups: inflammatory lesions, benign tumors, and precancerous lesions. A retrospective diabetes screening of 610 inpatients with histologically confirmed oral malignancies was also performed. The control group comprised 574 complaint-and tumor-free adults. Fasting blood glucose levels were determined in both groups, and the tumor location was registered in the cancer patients.RESULTS -Benign tumors were found in 14.5% and precancerous lesions in 8% of diabetic patients. In the control group these values were significantly lower, at 6.4 and 3.2%, respectively (P Ͼ 0.01). Earlier Hungarian screening studies indicated similar frequency of these lesions in the general population. The proportion of oral cavity lesions was higher among diabetic patients compared with that of the control patients. In the oral cancer patient group, diabetes was present in 14.6% and an elevated blood glucose level in 9.7%. These values are significantly higher than those for the tumor-free control group (P Ͻ 0.01). The gingival and labial tumor location was significantly more frequent among diabetic cancer patients than in the nondiabetic group (P Ͻ 0.01). The combination of diabetes and smoking means a higher risk for oral precancerous lesions and malignancies.CONCLUSIONS -Diabetes may be a risk factor for oral premalignancies and tumors. Diabetes Care 27:770 -774, 2004C orrelations between diabetes and inflammatory oral lesions were first published in the 19th century (1). Gingivitis and destructive periodontitis with a rapid loss of the teeth were described as cardinal, pathognomic symptoms of diabetes (2,3).The discovery of insulin treatment justified a close correlation between the disorder of the carbohydrate metabolism and oral inflammatory complications (4). The adequate treatment of diabetes results in marked improvement of the gingival and periodontal lesions.Diabetes patients have further inflammatory complications of the oral mucosa. The decreased rate of saliva secretion and the low pH value result in chronic cheilitis and glossitis with progressive atrophy of the covering epithelial layer (5).The inflammation-mediated carcinogenesis is a well-known empirical fact, but the exact pathway of this transition has not been perfectly clarified until now (6 -9). Is there any correlation between diabetes and tumor genesis of the oral cavity? Surprisingly, there are no literature data concerning this problem. Accordingly, in the present study, we have attempted...

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Epidemiologic studies of oral mucosal conditions – methodologic issues

Cited by 71 publications

References 82 publications

Opportunistic screening for oral cancer and precancer in general dental practice: results of a demonstration study

Opportunistic screening for oral cancer and precancer in general dental practice: results of a demonstration study

Oral cancer in the UK: to screen or not to screen

Diabetes and Oral Tumors in Hungary

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