Epidemiological and clinical characteristics of infants admitted to hospital due to human parechovirus infections: A prospective study in Spain

Valle, Fernando Martín del; Calvo, Cristina; Martínez-Rienda, Inés; Cilla, Amaia; Romero, María Pilar; Menasalvas, Ana; Reis-Iglesias, Leticia; Rodà, Diana; Peña, María José; Rabella, N; Red, María del Mar Portugués de la; Megías, Gregoria; Moreno-Docón, Antonio; Otero, Almudena; Cabrerizo, María

doi:10.1016/j.anpede.2017.02.010

Cited by 5 publications

(7 citation statements)

References 26 publications

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“…In both study groups, the most frequent diagnosis was febrile syndrome, accounting for almost half of the cases. However, meningitis was more prevalent in infants with EV infections and clinical sepsis in HPeV infections as described by previous authors (14,17,29). We further observed that the admission to the ICU and clinical sepsis were significantly more frequent in HPeV-infected infants, as previously reported by our research group (1,17).…”

Section: Discussionsupporting

confidence: 90%

“…However, meningitis was more prevalent in infants with EV infections and clinical sepsis in HPeV infections as described by previous authors (14,17,29). We further observed that the admission to the ICU and clinical sepsis were significantly more frequent in HPeV-infected infants, as previously reported by our research group (1,17). EV and HPeV infections are becoming better known to pediatricians, and although PCR is not available in all hospitals, it should be generalized.…”

Section: Discussionsupporting

confidence: 88%

“…Aizawa et al (15) described the incidence of hospitalization for HPeV-infection as 750/100,000 children under 4 months of age during the 2014 HPeV epidemic in Niigata, Japan; it was possible because the authors conduct virologic evaluation of all young infants at all pediatric care hospitals. HPeV type 3 has been implicated in the most severe infections in this age group (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

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Neurodevelopmental Outcomes of Infants Younger Than 90 Days Old Following Enterovirus and Parechovirus Infections of the Central Nervous System

et al. 2021

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Enteroviruses (EVs) and human parechoviruses (HPeVs) are a major cause of central nervous system (CNS) infection in young infants. They have been implicated in neurodevelopmental delay, however limited data are available. The aim of this study is to describe the clinical outcome of young infants and to assess and compare the medium-term neurodevelopment following CNS infections caused by EV and HPeV. A multicentre observational ambispective study was conducted between May 2013 and March 2018. Children under 3 months of age with EV or HPeV CNS infection excluding encephalitis were included. Infants were contacted 1 year after the acute infection and their neurological development was evaluated using the Ages and Stages Questionnaire-3 (ASQ-3). If any area assessed was abnormal during the first round of tests, a second round was completed 6 to 12 months later. Forty-eight young infants with EV and HPeV CNS infection were identified: 33 (68.8%) were positive for EV and 15 (31.3%) for HPeV. At first assessment 14 out of 29 EV (48.3%) and 3 out of 15 HPeV (20%) positive cases presented some developmental concern in the ASQ-3 test. EV-positive infants showed mild and moderate alteration in all domains analyzed and HPeV-positive infants showed mild alterations only in gross and fine motor domains. Significant alterations in communication were observed in EV-positive but not in HPeV-positive infants (31 vs. 0%, p = 0.016). At second assessment 4 out of 13 EV-positive patients (30.8%) showed mild to moderate concerns in communication and gross motor function domains and 3 out of 13 (23.1%) showed significant concern in fine motor function. Although CNS infections without associated encephalitis are generally assumed to be benign our study shows that at a median age of 18 months almost half of the EV-infected infants (48.3%) and 20% of HPeV-positive infants presented some developmental concern in the ASQ-3 test. We recommend monitor the neurological development of infants during the first years of life after HPeV CNS infection and especially after EV CNS infection, even in mild cases, for an early intervention and stimulation of psychomotor development if necessary.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Neurodevelopmental Outcomes of Infants Younger Than 90 Days Old Following Enterovirus and Parechovirus Infections of the Central Nervous System

et al. 2021

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“…In addition, the largest number of positive samples for PeV-A corresponded to gastrointestinal samples (feces and anal swab), with a frequency percentage of 4%, being within of the ranges previously reported for PeV-A in children with diarrhea, that corresponded from 2% to 16.3% (13,24). This percetage of 4% was similar to a Nigerian study of children with a similar age range (25), but lower than what has been reported in studies carried out in Chile, Spain and Malawi (19,20,26). Although a higher prevalence of PeV-A was obtained from stool samples, the clinical symptoms of the acute infection could not be directly related to PeV-A, since it has been shown that the duration of the virus in stool samples can last several months (27).…”

Section: Discussionsupporting

confidence: 80%

Detection of Human Parechovirus a in Respiratory, Gastrointestinal, and Neurological Clinical Samples of Pediatric Patients from Panama

Gutierrez¹,

Saenz²,

Franco³

et al. 2022

Preprint

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Human Parechoviruses, officially known as Parechovirus A (PeV-A), is associated with mild gastrointestinal and respiratory illness in young children, however, they may also give rise to Central Nervous System (CNS) infections and neonatal sepsis. While studies have delved into the detection of PeV-A in different populations, the detection of PeV-A in Hispanic populations in Latin American countries is not well-known. The aim of this study was to determine the presence of PeV-A in respiratory, gastrointestinal, and neurological clinical samples of pediatric patients in Panama. Two hundred samples of pediatric patients with a negative diagnosis for the main respiratory viruses, rotavirus and neurological viruses such as herpesvirus, enterovirus and cytomegalovirus, collected between 2014 and 2015, were analyzed by real-time RT-PCR. Eight positive PeV-A infections were detected, 2 in respiratory samples, 5 in stool samples and one detected in cerebrospinal fluid. This is the fisrt report of PeV-A in Panamá.

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“…The PeV-A prevalence of 4% was similar to a Nigerian study of children with a similar age range [24], but lower than what has been reported in studies carried out in Chile, Spain and Malawi [19,20,29]. Although a higher prevalence of PeV-A was obtained from stool samples, the clinical symptoms of the acute infection could not be directly related to PeV-A, since it has been shown that the duration of the virus in stool samples can last several months [25].…”

Section: Discussionsupporting

confidence: 77%

Detection of Human Parechovirus a in Respiratory, Gastrointestinal, and Neurological Clinical Samples of Hospitalized Patients in Panama

Saenz¹,

Gutierrez²,

Franco³

et al. 2022

Preprint

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Human parechoviruses, officially known as Parechovirus A (PeV-A), from the family Picornaviri-dae, genus Parechovirus, are non-enveloped, icosahedral, positive-sense RNA viruses associated with mild gastrointestinal and respiratory illness in young children, however, they may also give rise to Central Nervous System (CNS) infections and neonatal sepsis. While studies have delved into the detection of HPeVs in different populations, the detection of PeV-A in Hispanic populations in Latin American countries is not well-known. The aim of this study was to characterize PeV-A circulating in the Republic of Panama. Respiratory, gastrointestinal and neurological samples were collected from 200 Panamanian pe-diatric patients hospitalized between 2014 and 2015 and were analyzed for the presence of PeV-A by real-time RT-PCR. PeV-A positive samples were sequenced for genetic characterization. These samples followed predetermined inclusion criteria and were negative for viral/bacterial examinations that were requested by the patient's physician when the specimen was sent to the ICGES. Eight positive PeV-A infections (4%) were detected for the 200 subjects, in gastrointestinal samples. Human Parechovirus PeV-A was detected and genetically characterized for the first time in the Republic of Panama in samples from 2014 and 2015.

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Epidemiological and clinical characteristics of infants admitted to hospital due to human parechovirus infections: A prospective study in Spain

Cited by 5 publications

References 26 publications

Neurodevelopmental Outcomes of Infants Younger Than 90 Days Old Following Enterovirus and Parechovirus Infections of the Central Nervous System

Neurodevelopmental Outcomes of Infants Younger Than 90 Days Old Following Enterovirus and Parechovirus Infections of the Central Nervous System

Detection of Human Parechovirus a in Respiratory, Gastrointestinal, and Neurological Clinical Samples of Pediatric Patients from Panama

Detection of Human Parechovirus a in Respiratory, Gastrointestinal, and Neurological Clinical Samples of Hospitalized Patients in Panama

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