Epidemiological and clinical characteristics of mpox cases: reply

Pascom, Ana Roberta Pati; Souza, Isabella Nepomuceno de; Krummenauer, Amanda; Duarte, Magda Machado Saraiva; Sallas, Janaina; Rohlfs, Daniela Buosi; Pereira, Gerson Fernandes Mendes; Medeiros, Arnaldo Correia de; Miranda, Angélica Espinosa

doi:10.1590/s2237-96222023000100029

Cited by 3 publications

(5 citation statements)

References 2 publications

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“…In Mexico, HIV, syphilis, and some cases of chronic hepatitis C were also identified in patients with Mpox [31]. In Latin America, HIV, syphilis, genital herpes, chlamydia, and gonorrhea were reported in Brazil [32], while in Peru, only HIV and syphilis were reported in patients with Mpox infection [33,34].…”

Section: Sexually Transmitted Infections Concomitantmentioning

confidence: 99%

“…Up to 25 April, 3800 human Mpox cases and ten deaths were reported by the CDC Peru [34]. As in other countries [7,8,27,32], most of these cases occurred in young men (96.1%) and MSM (56%). The most-affected population is people living with HIV (55%) and those who receive antiretroviral therapy (85%) (Figure 4B) [34].…”

Section: Mpxv Outbreak In Perumentioning

confidence: 99%

“…Likewise, the WHO reports that among Mpox cases, approximately 50% of cases are HIV-positive people [22]. As in Peru, several reports in Europe, the United States, and Brazil describe a high rate of HIV infection among Mpox cases [7,[27][28][29][30][31][32][33]38,39]. Given the transmission route, MPXV could still find other transmission networks, and it could also start to spread among sex workers, their clients, and other population groups [37].…”

Section: Mpxv Outbreak In Perumentioning

confidence: 99%

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Monkeypox Outbreak in Peru: Reflections after the COVID-19 Pandemic

Ramírez-Soto¹

2023

Preprint

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Monkeypox is a zoonotic illness caused by the Orthopoxvirus monkeypox virus (MPXV). Since 1970, outbreaks of MPXV have occurred in several Sub-Saharan African countries. However, from May 2022 to April 2023, recent outbreaks of MPXV occurred in several countries outside of Africa, and these cases quickly spread to over 100 non-endemic countries on all continents. Because of this, in July 2022, World Health Organization declared monkeypox a Public Health Emergency of International. MPXV disproportionately affects men who have sex with men and members of the HIV-infected population. The current strategy for control and pre-exposure prophylaxis or post-exposure prophylaxis for people at high risk is vaccination. In this context, Peru has the fourth-highest number of MPXV cases in Latin America. Because of this, in this review, we describe public health indicators in Peru and reflect on the COVID-19 pandemic so that health authorities can join forces to identify and control MPXV transmission routes.

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Section: Sexually Transmitted Infections Concomitantmentioning

confidence: 99%

Section: Mpxv Outbreak In Perumentioning

confidence: 99%

Section: Mpxv Outbreak In Perumentioning

confidence: 99%

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Monkeypox Outbreak in Peru: Reflections after the COVID-19 Pandemic

Ramírez-Soto¹

2023

Preprint

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“…As of August 7, 2023, there have been 88,060 confirmed cases of Mpox with 147 deaths reported worldwide. Of these, 10,931 were reported in Brazil, resulting in 16 deaths (Brazil, 2023;Pascom et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Chemsex among men who have sex with men during the Mpox health crisis in Brazil: A nationwide web survey

Santos,

Ribeiro,

Lima

et al. 2024

Public Health Nursing

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ObjectiveTo understand the factors associated with the practice of chemsex among MSM in Brazil, especially during the Mpox health crisis, and to design effective prevention and intervention strategies specifically for this population.DesignA cross‐sectional and analytical study using an electronic survey, conducted from September to December 2022, during the peak of the Mpox outbreak in Brazil.SampleA total of 1452 MSM aged 18 and older.MeasurementsData were collected via the REDCap platform through a survey with 46 questions. These addressed demographic data, sexual affiliations, practices, experiences with Mpox, healthcare service usage, and stigma or fear related to Mpox.ResultsThe prevalence of chemsex was 19.42% (n = 282). Multivariate Poisson modeling indicated a high incidence of chemsex among those diagnosed with Mpox and those involved in high‐risk behaviors. The practice of chemsex was six times higher among those diagnosed with Mpox (95% CI: 4.73–9.10). MSM who engage in bugchasing had a prevalence twice that of the main outcome (95% CI: 1.31–3.16).ConclusionThere is a significant need for targeted interventions for MSM in Brazil, especially given the Mpox outbreak. This study highlights the strong relationships between chemsex, experiences with Mpox, and various sexual behaviors, underscoring the importance of effective public health initiatives.

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“…In this context, MPXV currently circulating in Brazil is probably genetically diverse as there have been multiple virus entries into the country from different regions of Europe and North America since the beginning of the outbreak. 23 Therefore, here we investigated the in vitro efficacy of tecovirimat in inhibiting the replication of 18 clinical isolates of MPXV obtained from patients from different regions of Brazil from June to August 2022.…”

mentioning

confidence: 99%

In vitro susceptibility of eighteen clinical isolates of human monkeypox virus to tecovirimat

Nunes

Higa

Oliveira

et al. 2023

Mem. Inst. Oswaldo Cruz

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BACKGROUND In 2022, an outbreak of mpox that started in European countries spread worldwide through human-to-human transmission. Cases have been mostly mild, but severe clinical presentations have been reported. In these cases, tecovirimat has been the drug of choice to treat patients with aggravated disease. OBJECTIVES Here we investigated the tecovirimat susceptibility of 18 clinical isolates of monkeypox virus (MPXV) obtained from different regions of Brazil. METHODS Different concentrations of tecovirimat were added to cell monolayers infected with each MPXV isolate. After 72 hours, cells were fixed and stained for plaque visualization, counting, and measurement. The ortholog of F13L gene from each MPXV isolate was polymerase chain reaction (PCR)-amplified, sequenced, and the predicted protein sequences were analyzed. FINDINGS The eighteen MPXV isolates generated plaques of different sizes. Although all isolates were highly sensitive to the drug, two showed different response curves and IC 50 values. However, the target protein of tecovirimat, F13 (VP37), was 100% conserved in all MPXV isolates and therefore does not explain the difference in sensitivity. MAIN CONCLUSIONS Our results support screening different MPXV isolates for tecovirimat susceptibility as an important tool to better use of the restricted number of tecovirimat doses available in low-income countries to treat patients with mpox.

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Epidemiological and clinical characteristics of mpox cases: reply

Cited by 3 publications

References 2 publications

Monkeypox Outbreak in Peru: Reflections after the COVID-19 Pandemic

Monkeypox Outbreak in Peru: Reflections after the COVID-19 Pandemic

Chemsex among men who have sex with men during the Mpox health crisis in Brazil: A nationwide web survey

In vitro susceptibility of eighteen clinical isolates of human monkeypox virus to tecovirimat

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