Epidemiological and clinical characteristics of nosocomial candidiasis in university hospitals in Cuiabá – Mato Grosso, Brazil

Yamamoto, Ana Caroline Akeme; Paula, Claudete Rodrigues; Dias, Luciana Basili; Tadano, Tomoko; Martins, Elisabeth Nogueira; Amadio, Janaína Vasconcelos Ribeiro de Souza; Hahn, Rosane Christine

doi:10.1016/j.riam.2012.01.001

Cited by 14 publications

(11 citation statements)

References 16 publications

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“…However, Chang et al 19 reported a prevalence of C. albicans of 45.8% among analyzed candidemia infections at the University Hospital of the State of Mato Grosso do Sul. In Brazil and in our study, several studies have indicated C. tropicalis as the second most frequent isolate in cases of candidemia among hospitalized patients 12,20,24 . C. tropicalis is the fourth most frequent Candida species isolated in cases of candidemia in the United States 30 and the third most frequent isolate in Spain 8 and Asia 6 .…”

Section: Discussionsupporting

confidence: 64%

“…These results are similar to other recent studies conducted in central-western Brazil. Yamamoto et al 20 reported a prevalence of C. albicans of 39% among isolates in Cuiabá, State of Mato Grosso, and other reports from the same country have indicated a predominance of NCAC species over C. albicans in clinical samples isolated from hospitalized patients 12,24 .…”

Section: Discussionmentioning

confidence: 94%

“…Furnaleto et al 12 observed that infections caused by Candida spp. were more frequent in older people (> 61 years), those less than one year old, and among ICU patients 19,20 .…”

Section: Discussionmentioning

confidence: 97%

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Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Almeida

Shinobu-Mesquita

Svidzinski

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Hospital infections caused by Candida spp. are a leading cause of morbidity and mortality in hospitalized patients, particularly those that are critically ill or immunocompromised. In this study, the distributio n of Candida species in isolates from the University Hospital of the Federal University at Grande Dourados and their in vitro susceptibility to antifungal drugs were analyzed. Methods: Yeasts were phenotypically identifi ed using classical methodologies. Antifungal susceptibility tests to amphotericin B and fl uconazole were performed using the broth microdilution technique. Results: A total of 50 Candida isolates were obtained from hospitalized patients during the study period. We analyzed yeast isolates from urine (n=31; 62%), blood (n=12; 24%), and tracheal secretions (n=7; 14%). The following Candida species were identifi ed: C. tropicalis (n=21; 42%), C. albicans (n=18; 36%), C. glabrata (n=10; 20%), and C. krusei (n=1; 2%). Antifungal susceptibility tests demonstrated that C. albicans was susceptible to both antifungal agents. However, 31.2% of the non-C. albicans Candida isolates displayed dose-dependent susceptibility to fl uconazole, and 3.1% were resistant to amphotericin B. Conclusions: In contrast to previous reports, our results indicated that C. tropicalis was the most commonly isolated yeast species among the hospital patients. The predominance of non-C. albicans Candida infections confi rms the importance of species-level identifi cation for implementing appropriate antifungal therapies.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 94%

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Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Almeida

Shinobu-Mesquita

Svidzinski

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…The rate of Candida infections (5.6 per 1,000 admissions) and the rate of candidemia (2.9 per 1,000 admissions) in our population was comparable with other studies. 12,14,15 There are also other studies reporting lower incidence rates. 16,17 Comparisons are problematic because nosocomial Candida infection rates may differ between different centers, reflecting variations in demographic and clinical characteristics of patient populations, principles of antibiotics practices, implementation of infection control precautions, and blood culture methods.…”

Section: Discussionmentioning

confidence: 98%

“…The rank order of species in cases of candidemia were the same, in accordance with some pediatric series, 12,21,28 whereas contrasting with some other. 14,16,23 The increase in the rate of C parapsilosis among bloodstream isolates (from 13% in all systemic candidiasis episodes to 22.2% in candidemia episodes) was substantial. The high transmission rate of C parapsilosis among candidemia patients was reported before.…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic and microbiologic evaluation of nosocomial infections associated with Candida spp in children: A multicenter study from Istanbul, Turkey

Sütçü

Salman

Aktürk

et al. 2016

American Journal of Infection Control

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Six-Year Trend Analysis of Nosocomial Candidemia and Risk factors in Two Intensive Care Hospitals in Mato Grosso, Midwest Region of Brazil

et al. 2013

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We conducted this cross-sectional retrospective study using clinical and laboratory data from two tertiary hospitals in Cuiabá, Mato Grosso, Brazil, in order to explore the risk factors and estimate mortality, prevalence and lethality of candidemia between 2006 and 2011. A total of 130 episodes of candidemia were identified. The prevalence of candidemia was 1.8 per 1,000 admissions, the mortality rate was 0.9 per 1,000 admissions, and the lethality was 49.2 %. The main agent in this population was Candida parapsilosis (n = 50), followed by C. albicans (n = 45). Comparison between the numbers of episodes in the two triennia revealed that the non-albicans group grew by 48.2 %. The distribution of yeast species of Candida per hospital unit revealed that C. albicans was more prevalent than C. parapsilosis in the adult ICU and C. parapsilosis was more prevalent than C. albicans in the neonatal ICU. Patients remained hospitalized for an average of 53.5 days. Central venous catheters, parenteral nutrition and age were the variables that proved to be independent in the multivariate analysis and that maintained a statistically significant association with the incidence of death in patients with candidemia. The annual prevalence of candidemia showed a significant increase in the second triennium (2009-2011) compared with the first (2006-2008) probably due to increased exposure to risk factors: central venous catheter, H2 blockers, nutrition parenteral corticosteroids and mean hospital duration.

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Epidemiological and clinical characteristics of nosocomial candidiasis in university hospitals in Cuiabá – Mato Grosso, Brazil

Cited by 14 publications

References 16 publications

Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Epidemiologic and microbiologic evaluation of nosocomial infections associated with Candida spp in children: A multicenter study from Istanbul, Turkey

Six-Year Trend Analysis of Nosocomial Candidemia and Risk factors in Two Intensive Care Hospitals in Mato Grosso, Midwest Region of Brazil

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