Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China

Yang, Yicheng; Lu, Quanming; M, Liu; Wang, Y; Zhang, A; Jalali, Neda; Ne, Dean; Longini, Ira M.; Me, Halloran; Xu, Biao; Zhang, X.; Wang, L; W, Liu; Fang, Li‐Qun

doi:10.1101/2020.02.10.20021675

Cited by 493 publications

(563 citation statements)

References 21 publications

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“…The presenting features in adults are pronounced. The most common clinical symptoms of SARS-CoV-2 infection were fever (87.9%), cough (67.7%), fatigue (38.1%), whereas diarrhea (3.7%) and vomiting (5.0%) were rare [15,31], which were similar to others coronavirus.…”

Section: Clinical Characteristics Of Sars-cov-2 Infectionmentioning

confidence: 91%

Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence

Wang

et al. 2020

International Journal of Antimicrobial Agents

981

815

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Section: Clinical Characteristics Of Sars-cov-2 Infectionmentioning

confidence: 91%

Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence

Wang

et al. 2020

International Journal of Antimicrobial Agents

981

815

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“…The second phase started on January 13, marked by rapid expansion and spread of the virus within hospitals (nosocomial infection) and by family transmission (close-contact transmission). In this phase the epidemic spread from Wuhan to other areas [12][13][14][15][16][17][18]. The first case outside of China was reported in Thailand on January 13, caused by a Wuhan resident travelling to this country.…”

Section: Epidemiology Of Covid-19mentioning

confidence: 99%

COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives

Sun

Wang

et al. 2020

Trends in Molecular Medicine

588

526

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“…8 The reproductive number (R0), defined as the expected number of secondary infectious cases generated by an infectious case in a susceptible population, is estimated to 3.77. 9 Recent publications have depicted the epidemiological and clinical characteristics of patients infected with SARS-CoV-2. 2 , 3 , 7 , 9-11 The definite diagnosis of COVID-19 is expected with the novel coronavirus nucleic acid positive in swabs, sputum, or secretions from the lower respiratory tract, or blood by real-time reverse transcription polymerase chain reaction assay (RT-PCR).…”

Section: Introductionmentioning

confidence: 99%

Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children

Liu¹,

Liu²,

Li³

et al. 2020

Journal of Infection

373

213

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s u m m a r yBackground: The ongoing outbreak of COVID-19 pneumonia is globally concerning. We aimed to investigate the clinical and CT features in the pregnant women and children with this disease, which have not been well reported. Methods: Clinical and CT data of 59 patients with COVID-19 from January 27 to February 14, 2020 were retrospectively reviewed, including 14 laboratory-confirmed non-pregnant adults, 16 laboratory-confirmed and 25 clinically-diagnosed pregnant women, and 4 laboratory-confirmed children. The clinical and CT features were analyzed and compared. Findings: Compared with the non-pregnant adults group ( n = 14), initial normal body temperature (9 [56%] and 16 [64%]), leukocytosis (8 [50%] and 9 [36%]) and elevated neutrophil ratio (14 [88%] and 20 [80%]), and lymphopenia (9 [56%] and 16 [64%]) were more common in the laboratory-confirmed ( n = 16) and clinically-diagnosed ( n = 25) pregnant groups. Totally 614 lesions were detected with predominantly peripheral and bilateral distributions in 54 (98%) and 37 (67%) patients, respectively. Pure ground-glass opacity (GGO) was the predominant presence in 94/131 (72%) lesions for the non-pregnant adults. Mixed consolidation and complete consolidation were more common in the laboratory-confirmed (70/161 [43%]) and clinically-diagnosed (153/322 [48%]) pregnant groups than 37/131 (28%) in the non-pregnant adults ( P = 0 ·007, P < 0 ·001). GGO with reticulation was less common in 9/161 (6%) and 16/322 (5%) lesions for the two pregnant groups than 24/131 (18%) for the non-pregnant adults ( P = 0 ·001, P < 0 ·001). The pulmonary involvement in children with COVID-19 was mild with a focal GGO or consolidation. Twentythree patients underwent follow-up CT, revealing progression in 9/13 (69%) at 3 days whereas improvement in 8/10 (80%) at 6-9 days after initial CT scans. Interpretation: Atypical clinical findings of pregnant women with COVID-19 could increase the difficulty in initial identification. Consolidation was more common in the pregnant groups. The clinically-diagnosed cases were vulnerable to more pulmonary involvement. CT was the modality of choice for early detection, severity assessment, and timely therapeutic effects evaluation for the cases with epidemic and clinical features of COVID-19 with or without laboratory confirmation. The exposure history and clinical symptoms were more helpful for screening in children versus chest CT.

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Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China

Cited by 493 publications

References 21 publications

Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence

Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence

COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives

Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children

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