Epidemiological and Economic Burden of Alzheimer's Disease: A Systematic Literature Review of Data across Europe and the United States of America

Abstract

This review corroborates previous understanding that AD burden is high for both society and healthcare providers. Limitations regarding study heterogeneity restricted conclusions; further research is required. Stakeholders could benefit from new healthcare strategies addressing both epidemiological and economic aspects of AD.

2,4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies

“…Neurodegenerative disorders elicit substantial socioeconomic impacts atop the mounting burdens on the healthcare and caregiver networks [1]. In the case of Alzheimer's disease (AD), its progressive nature, coupled with an undefined origin adds a complex dimension to its pathology.…”

Neuronal histamine and cognitive symptoms in Alzheimer's disease

“…Both sporadic and genetic-familial forms of Alzheimer's disease have been identified. However the exact causes of Alzheimer's disease are still not completely understood at this time (Takizawa et al, 2014). Major histopathological hallmarks of Alzheimer's disease include neurodegeneration, the loss of synapses as well as an increase in extracellular Ab plaque deposits and intracellular neurofibrillary tangles in the brain (McGhee et al, 2014;Yankner, 2000).…”

Thyroid Hormone Enhances Neurite Outgrowth in Neuroscreen 1 Cells

“…Although the course of the disease is unique for every person, several psychological and physical symptoms are characteristic of all patients [3,4]. The earliest and most prominent [5,6].…”

“…Similarly, hypothyroidism also becomes more common with aging as with AD [19]. Interestingly, among the symptoms associated with untreated hypothyroidism include memory loss, lack of concentration, and dementia [19][20][21], which mimic some of the initial symptoms of AD [3,4]. Therefore, it is possible that the overlap between some of the symptoms of these two diseases contributes to the susceptibility to AD for patients who have been diagnosed with hypothyroidism.…”