Epidemiological and etiological investigation of dengue fever in the Fujian province of China during 2004–2014

Abstract

Dengue fever (DF) is a vector-borne disease and a tremendous socioeconomic burden on tropical and subtropical countries worldwide. To explore the characteristics of DF epidemic in the Fujian province, information of DF cases in Fujian during 2004-2014 was collected and analyzed. The complete E genes of 48 viral isolates were amplified and sequenced for phylogenetic analysis. A total of 733 cases was reported, of which 612 (83.5%) occurred during the peak period from August to October. Additionally, 76% (190/250) of imported cases originated from Southeast Asia countries, by the epidemiological investigation. Phylogenetic analysis of the 48 viral isolates revealed that three genotypes (I, IV, V) of DENV1, and one genotype each of DENV2 (cosmopolitan) and DENV3 (I) circulated in Fujian during [2004][2005][2006][2007][2008][2009][2010][2011][2012][2013][2014]. Similar to the results of the epidemiological investigations, the source of most of the viral isolates, including imported and indigenous cases, may be Southeast Asia countries; however, importation from adjacent provinces was also observed in recent years. Overall, DF is considered an imported epidemic disease in Fujian. Increasing diversity of the viral source and geographic expansion of the area affected by DF in recent years highlights the necessity for strengthening surveillance of the DF epidemic and developing strategies for DF prevention and control in Fujian.dengue virus, E gene, phylogenetic tree, epidemiology, etiology Citation:

Mosquito-Associated Viruses in China

“…These outbreaks of dengue fever in China are suspected to result from virus imported by infected travelers coming from dengue-endemic regions or local epidemics initiated by imported cases. Recently, dengue fever has shown an increasing drift especially in the four main hotspot areas, namely Guangdong, Fujian, Zhejiang, and more recently Yunnan (Gu et al 2012 ; Sun et al 2011 ; Yan et al 2010 ; Yang et al 2015 ; Zhang et al 2014 ; Zhao et al 2016 ). According to the China National Notifiable Disease Surveillance System, from the year 2002–2016, the incidence ranged from 0.01 to 3.46 per 100,000 people, with a total of seven deaths reported.…”

Treatment seeking behavior and associated factors of suspected dengue fever among Shan people in eastern Shan special region IV, Myanmar: a cross-sectional study

“…Improved treatment for dengue fever (DF) has decreased the case fatality rate by approximately half with each decade since 1980 [6]. Dengue has replaced malaria to become another threat to public health along the China-Myanmar border [7,8] as malaria has been successfully controlled [9]. More prompt and proper interventions are needed now because of the unavailability of anti-dengue drugs and low efficacy of current dengue vaccines [10,11].…”

Spatiotemporal characteristics and primary influencing factors of typical dengue fever epidemics in China

“…With the acceleration of globalization and China’s increasingly frequent international exchanges, the prevalence of DF induced by imported cases has increased substantially [3–6]. In recent years, DF epidemics have frequently occurred not only in southern China [7–9] but also in some inland areas, such as Henan (Xuchang) and Shandong (Jining) [10]. Overall, China’s DF epidemic has shown increasingly shorter time intervals and a wider spread.…”