Epidemiological and genetic characteristics of respiratory syncytial virus infection in children from Hangzhou after the peak of COVID-19

Guo, Yajun; Wang, Bing-han; Lin, Li; Li, Yaling; Chu, Xiaoli; Li, Wei

doi:10.1016/j.jcv.2022.105354

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…While the US experienced an RSV-B dominant season after the easing of NPIs in 2021–2022, potentially contributing to the observed monophyletic outgrowth, several other countries experienced an RSV-A dominant season 37 – 39 .To determine whether this monophyletic cluster of RSV-B was unique to the US, we generated a temporal ML phylogenetic analysis using all publicly available RSV-B whole genome sequences collected between 1957 and 2023 ( n = 723) (Fig. 5a ).…”

Section: Resultsmentioning

confidence: 99%

Deviations in RSV epidemiological patterns and population structures in the United States following the COVID-19 pandemic

Rios-Guzman,

Simons,

Dean

et al. 2024

Nat Commun

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Respiratory Syncytial Virus (RSV) is a leading cause of acute respiratory tract infection, with the greatest impact on infants, immunocompromised individuals, and older adults. RSV prevalence decreased substantially in the United States (US) following the implementation of COVID-19-related non-pharmaceutical interventions but later rebounded with abnormal seasonality. The biological and epidemiological factors underlying this altered behavior remain poorly defined. In this retrospective cohort study from 2009 to 2023 in Chicago, Illinois, US, we examined RSV epidemiology, clinical severity, and genetic diversity. We found that changes in RSV diagnostic platforms drove increased detections in outpatient settings post-2020 and that hospitalized adults infected with RSV-A were at higher risk of intensive care admission than those with RSV-B. While population structures of RSV-A remained unchanged, RSV-B exhibited a genetic shift into geographically distinct clusters. Mutations in the antigenic regions of the fusion protein suggest convergent evolution with potential implications for vaccine and therapeutic development.

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Section: Resultsmentioning

confidence: 99%

Deviations in RSV epidemiological patterns and population structures in the United States following the COVID-19 pandemic

Rios-Guzman,

Simons,

Dean

et al. 2024

Nat Commun

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“…Previous studies have shown that children who received the Pfizer vaccine are less likely to have severe COVID‐19 18–23 . Like adults, children can also have adverse reactions from the COVID‐19 vaccines, including sore arms, muscle aches, fever, and chills.…”

Section: Introductionmentioning

confidence: 99%

“…The available safety data 18–23 to support emergency use authorization in adolescents aged < 12 years comprise 2260 individuals aged 12–15 years enrolled in a randomized, placebo‐controlled clinical trial in the United States. In this analysis, the measured antibody response of adolescents was non‐inferior to the measured antibody response of the older participants.…”

Section: Introductionmentioning

confidence: 99%

“…17 Previous studies have shown that children who received the Pfizer vaccine are less likely to have severe COVID-19. [18][19][20][21][22][23] Like adults, children can also have adverse reactions from the COVID-19 vaccines, including sore arms, muscle aches, fever, and chills. Most adverse reactions are mild and may last 1-2 days, and symptoms can be managed with acetaminophen.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, patients vaccinated before transplantation may have reduced protection after transplantation, mainly if therapies that reduce B-cell function (e.g., rituximab) are utilized. [28][29][30][31][32][33][34][35] The available safety data [18][19][20][21][22][23] severe disease and prolonged admission and late recovery. [37][38][39][40][41][42] Hence, the benefits of vaccination outweigh any theoretical risks, especially in countries where SARS-CoV-2 transmission continues at a high level.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Coronavirus disease 2019 vaccine in pediatric post‐kidney transplantation

Ajlan

Aleid

Ali

et al. 2023

Clinical Transplantation

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Background Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infections and the resulting disease, coronavirus disease 2019 (COVID‐19), have spread to millions of persons worldwide. Many vaccines have been developed; however, their efficacy in pediatric solid organ transplant recipients is yet to be determined. Methods This is a prospective observational, non‐interventional single‐center study on the safety and efficacy of a COVID‐19 vaccine (BNT162b2) in pediatric kidney transplant recipients. The primary aim of this study was to evaluate immunogenicity according to SARS‐CoV‐2‐specific neutralizing antibody titer after two vaccine doses. The secondary aims were to investigate the safety of the vaccines, solicited local and systemic adverse reactions, incidence of COVID‐19 post‐vaccination, and effects on transplant graft function. Baseline investigations were conducted on pediatric renal transplant recipients, and recruited participants were advised to have the Comirnaty® mRNA vaccine according to protocol. Results A total of 48 patients (male, n = 31, 64.6%; female, n = 17, 35.4%), median age 14 [12–16] years were included, and all received two doses of the vaccine. The vaccine had a favorable safety and side‐effect profile. The S‐antibody titer of all patients ranged between .4 and 2,500 U/ml and was > 50 U/ml in 89% of the patients. No difference in the measured antibody immune response was noted between infected and uninfected children. No major side effects were reported. Conclusion The vaccine had a favorable safety profile in 12‐ to 15‐year‐old kidney transplant recipients, producing a greater measured antibody response than that in older transplant recipients.

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Changes in Epidemics of Respiratory Viral Infections Resulted From the COVID‐19 Pandemic in Shanghai

Ye,

Tian,

Huo

et al. 2024

Journal of Medical Virology

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To investigate the changing patterns of respiratory viral infections within the context of COVID‐19 pandemic. The etiological surveillance data of eight respiratory viral pathogens among patients with ARIs in Shanghai between 2013 and 2023 were analyzed to evaluate the dynamic patterns of respiratory viral infections in Shanghai compared to global other regions during pre‐pandemic (period 1), pandemic (period 2), and post‐pandemic (period 3) periods of COVID‐19. In Shanghai and various other global regions, there was a delay of 2‒4 months in the peak positive rate of IFV and a reverse seasonality for RSV, HMPV, and HBoV was observed following the relaxation of NPIs. The proportion of patients infected with any of these eight viruses experiencing fever or high fever notably increased. During the entire study period, IFV was consistently identified as the most prevalent virus, with IFV‐B as the predominant stain during period 2, and IFV‐A regained its dominance following the lifting of NPIs. The proportion of RSV among children significantly increased during period 2 compared to period 1. With the relaxation of NPIs, there has been a resurgence of certain viral pathogens, accompanied by notable alterations in seasonal patterns and the spectrum of viral pathogens.

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Epidemiological and genetic characteristics of respiratory syncytial virus infection in children from Hangzhou after the peak of COVID-19

Cited by 9 publications

References 25 publications

Deviations in RSV epidemiological patterns and population structures in the United States following the COVID-19 pandemic

Deviations in RSV epidemiological patterns and population structures in the United States following the COVID-19 pandemic

Coronavirus disease 2019 vaccine in pediatric post‐kidney transplantation

Changes in Epidemics of Respiratory Viral Infections Resulted From the COVID‐19 Pandemic in Shanghai

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